Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YKR014C
Length:
234
Number of sequences:
5887
Description:
YKR014C YPT52 SGDID:S000001722, Chr XI from 466071-465367, Genome Release 64-1-1, reverse complement, Verified ORF, "Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
631P63000    192   RAC1_HUMAN Ras-related C3 botulinum toxin sub...1900.000000000007     65.5     25     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; TAS:UniProtKB.::GO:0031996; F:thioesterase binding; IPI:UniProtKB.
GO:0030041; P:actin filament polymerization; TAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0048870; P:cell motility; IDA:UniProtKB.::GO:0007160; P:cell-matrix adhesion; NAS:BHF-UCL.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0006954; P:inflammatory response; TAS:ProtInc.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0051668; P:localization within membrane; IMP:BHF-UCL.::GO:0032707; P:negative regulation of interleukin-23 production; IDA:BHF-UCL.::GO:0048261; P:negative regulation of receptor-mediated endocytosis; TAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0010592; P:positive regulation of lamellipodium assembly; IDA:MGI.::GO:0035025; P:positive regulation of Rho protein signal transduction; TAS:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0010310; P:regulation of hydrogen peroxide metabolic process; TAS:BHF-UCL.::GO:0060263; P:regulation of respiratory burst; IDA:BHF-UCL.::GO:0031529; P:ruffle organization; TAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
632P62999    192   RAC1_CANFA Ras-related C3 botulinum toxin sub...1900.000000000007     65.5     25     47GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:UniProtKB.
GO:0048870; P:cell motility; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
633P62998    192   RAC1_BOVIN Ras-related C3 botulinum toxin sub...1900.000000000007     65.5     25     47GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; ISS:UniProtKB.
GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
634Q9D8T3    184   REBL1_MOUSE GTPase RhebL1 OS=Mus musculus (Mo...1820.000000000007     65.1     28     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
635Q00246    291   RHO4_YEAST GTP-binding protein RHO4 OS=Saccha...1280.000000000007     66.6     32     52GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005624; C:membrane fraction; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:SGD.
GO:0030011; P:maintenance of cell polarity; IGI:SGD.::GO:0090337; P:regulation of formin-nucleated actin cable assembly; IPI:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
636P79737    188   RASN_DANRE GTPase NRas OS=Danio rerio (Zebraf...2100.000000000007     65.1     26     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
637Q04970    189   RASN_RAT GTPase NRas OS=Rattus norvegicus (Ra...2000.000000000007     65.1     28     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
638Q9YH38    188   RASK_CYPCA GTPase KRas OS=Cyprinus carpio (Co...1860.000000000007     65.1     28     49GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
639P12825    189   RASN_CAVPO GTPase NRas OS=Cavia porcellus (Gu...2000.000000000008     65.1     28     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
640Q2MJK3    189   RASN_PIG GTPase NRas OS=Sus scrofa (Pig). GN=...2000.000000000008     65.1     28     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
641P01111    189   RASN_HUMAN GTPase NRas OS=Homo sapiens (Human...2000.000000000008     65.1     28     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
642P79800    188   RASK_MELGA GTPase KRas OS=Meleagris gallopavo...1860.000000000008     65.1     28     48GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
643Q6ZHA3    197   RAC6_ORYSJ Rac-like GTP-binding protein 6 OS=...1840.000000000008     65.1     27     47
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
644Q41253    196   RAC13_GOSHI Rac-like GTP-binding protein RAC1...1840.000000000009     65.1     27     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
645Q95ME4    189   RASN_MONDO GTPase NRas OS=Monodelphis domesti...2000.00000000001     64.7     28     48GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
646Q40220    196   RAC2_LOTJA Rac-like GTP-binding protein RAC2 ...1840.00000000001     64.7     26     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
647P01116    189   RASK_HUMAN GTPase KRas OS=Homo sapiens (Human...2120.00000000001     64.7     28     49GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
648Q38903    201   RAC2_ARATH Rac-like GTP-binding protein ARAC2...1840.00000000001     64.7     27     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
649Q5R988    183   RAP2A_PONAB Ras-related protein Rap-2a OS=Pon...1930.00000000001     64.3     29     48GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0034613; P:cellular protein localization; ISS:UniProtKB.::GO:0031954; P:positive regulation of protein autophosphorylation; ISS:UniProtKB.::GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.
650Q80ZJ1    183   RAP2A_MOUSE Ras-related protein Rap-2a OS=Mus...1930.00000000001     64.3     29     48GO:0005829; C:cytosol; IDA:MGI.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0034613; P:cellular protein localization; ISS:UniProtKB.::GO:0030336; P:negative regulation of cell migration; IDA:MGI.::GO:0031954; P:positive regulation of protein autophosphorylation; IDA:MGI.::GO:0032486; P:Rap protein signal transduction; IDA:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.
651Q9HF56    191   CDC42_ASHGO Cell division control protein 42 ...1880.00000000001     64.3     24     47GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
652Q3SZA1    215   RHOF_BOVIN Rho-related GTP-binding protein Rh...2130.00000000002     64.3     25     44GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
653Q9XGU0    209   RAC9_ARATH Rac-like GTP-binding protein ARAC9...2090.00000000002     64.3     27     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
654Q8TAI7    183   REBL1_HUMAN GTPase RhebL1 OS=Homo sapiens (Hu...1850.00000000002     63.9     28     47GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0031929; P:TOR signaling cascade; IMP:UniProtKB.
655P20171    189   RASH_RAT GTPase HRas OS=Rattus norvegicus (Ra...1860.00000000002     63.9     27     47GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IMP:RGD.::GO:0045740; P:positive regulation of DNA replication; IMP:RGD.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD.::GO:0007265; P:Ras protein signal transduction; IMP:RGD.::GO:0035176; P:social behavior; IEP:RGD.
656Q61411    189   RASH_MOUSE GTPase HRas OS=Mus musculus (Mouse...1860.00000000002     63.9     27     47GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005525; F:GTP binding; IDA:MGI.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0008283; P:cell proliferation; IPI:MGI.::GO:0006897; P:endocytosis; IDA:MGI.::GO:0008629; P:induction of apoptosis by intracellular signals; IMP:MGI.::GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0007265; P:Ras protein signal transduction; TAS:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
657P01112    189   RASH_HUMAN GTPase HRas OS=Homo sapiens (Human...1860.00000000002     63.9     27     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007050; P:cell cycle arrest; IDA:BHF-UCL.::GO:0090398; P:cellular senescence; IDA:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0031575; P:mitotic cell cycle G1/S transition checkpoint; IDA:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009887; P:organ morphogenesis; TAS:ProtInc.::GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.::GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; IDA:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.
658P92978    197   RAC11_ARATH Rac-like GTP-binding protein ARAC...1840.00000000002     63.9     27     48GO:0045177; C:apical part of cell; IDA:TAIR.::GO:0005730; C:nucleolus; IDA:TAIR.::GO:0009524; C:phragmoplast; IDA:TAIR.::GO:0005886; C:plasma membrane; TAS:TAIR.::GO:0005819; C:spindle; IDA:TAIR.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0032794; F:GTPase activating protein binding; IPI:TAIR.
GO:0051650; P:establishment of vesicle localization; IDA:TAIR.::GO:0009860; P:pollen tube growth; IMP:TAIR.::GO:0030834; P:regulation of actin filament depolymerization; IGI:TAIR.::GO:0030833; P:regulation of actin filament polymerization; IGI:TAIR.::GO:0017157; P:regulation of exocytosis; IDA:TAIR.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
659Q03206    191   RAC1_CAEEL Ras-related protein ced-10 OS=Caen...1880.00000000003     63.5     25     46GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.::GO:0031410; C:cytoplasmic vesicle; IDA:WormBase.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005626; C:insoluble fraction; IDA:WormBase.::GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0009898; C:internal side of plasma membrane; IDA:WormBase.::GO:0005625; C:soluble fraction; IDA:WormBase.
GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048846; P:axon extension involved in axon guidance; IGI:WormBase.::GO:0031103; P:axon regeneration; IMP:WormBase.::GO:0010171; P:body morphogenesis; IGI:WormBase.::GO:0033563; P:dorsal/ventral axon guidance; IGI:WormBase.::GO:0043652; P:engulfment of apoptotic cell; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040039; P:inductive cell migration; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0008045; P:motor axon guidance; IGI:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0001764; P:neuron migration; IGI:WormBase.::GO:0040026; P:positive regulation of vulval development; IMP:WormBase.::GO:0030334; P:regulation of cell migration; IDA:UniProtKB.::GO:0050764; P:regulation of phagocytosis; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IDA:UniProtKB.
660P05774    183   RAS_CARAU Ras-like protein OS=Carassius aurat...2070.00000000003     63.5     28     49GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
661O04369    197   RAC1_LOTJA Rac-like GTP-binding protein RAC1 ...1840.00000000003     63.5     27     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
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