UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YKL113C

Length:

382

Number of sequences:

5887

Description:

YKL113C RAD27 SGDID:S000001596, Chr XI from 225875-224727, Genome Release 64-1-1, reverse complement, Verified ORF, "5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
181	B1L6R9	342	FEN_KORCO Flap endonuclease 1 OS=Korarchaeum ...	361	6e-51	179	34	54
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
182	A2SQC6	333	FEN_METLZ Flap endonuclease 1 OS=Methanocorpu...	332	5e-49	174	34	51
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
183	Q9HJD4	336	FEN_THEAC Flap endonuclease 1 OS=NBRC 15155 /...	326	3e-47	169	33	52
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
184	Q2FNC9	333	FEN_METHJ Flap endonuclease 1 OS=Methanospiri...	314	6e-47	169	34	54
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
185	Q5UQW7	473	YL386_MIMIV Putative endonuclease L386 OS=Aca...	241	1e-44	166	38	58
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:InterPro.
186	Q97B98	335	FEN_THEVO Flap endonuclease 1 OS=15438 / GSS1...	326	1e-44	162	32	51
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
187	Q18HK0	326	FEN_HALWD Flap endonuclease 1 OS=Haloquadratu...	338	1e-38	146	30	49
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
188	Q5V5T7	326	FEN_HALMA Flap endonuclease 1 OS=B-1809) (Hal...	333	1e-33	132	29	47
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
189	Q3IPG8	328	FEN_NATPD Flap endonuclease 1 OS=Natronomonas...	283	3e-33	131	32	48
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
190	Q9HQ27	327	FEN_HALSA Flap endonuclease 1 OS=(Halobacteri...	327	6e-29	119	29	46
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
191	B0R5F5	327	FEN_HALS3 Flap endonuclease 1 OS=Halobacteriu...	327	6e-29	119	29	46
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
192	Q91FF5	415	VF369_IIV6 Probable RAD2-like endonuclease 36...	320	6e-24	105	28	43	GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:InterPro.
193	Q6GZN0	363	095R_FRG3G Putative RAD2-like endonuclease 09...	308	7e-19	90.1	26	40	GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:InterPro.
194	Q12086	430	DIN7_YEAST DNA damage-inducible protein DIN7 ...	275	8e-19	90.9	29	45	GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IDA:SGD.
195	Q09708	496	YAGG_SCHPO Uncharacterized protein C12G12.16c...	186	1e-18	90.9	31	54	GO:0005737; C:cytoplasm; IDA:PomBase.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:InterPro.
196	P07276	1031	RAD2_YEAST DNA repair protein RAD2 OS=Sacchar...	91	0.00000000003	68.6	40	60	GO:0000112; C:nucleotide-excision repair factor 3 complex; IDA:SGD.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003697; F:single-stranded DNA binding; IEA:InterPro.::GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; IDA:SGD.
									GO:0006295; P:nucleotide-excision repair, DNA incision, 3'-to lesion; IMP:SGD.
197	Q17RS7	908	GEN_HUMAN Flap endonuclease GEN homolog 1 OS=...	254	3e-17	87	28	46	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
198	Q54ED2	1046	EXO1_DICDI Exonuclease 1 OS=Dictyostelium dis...	308	3e-16	84.3	28	45	GO:0005634; C:nucleus; ISS:dictyBase.
									GO:0008409; F:5'-3' exonuclease activity; ISS:dictyBase.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006310; P:DNA recombination; ISS:dictyBase.::GO:0006281; P:DNA repair; ISS:dictyBase.
199	Q9W6K2	734	EXO1_XENLA Exonuclease 1 OS=Xenopus laevis (A...	329	3e-16	84	29	43	GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0048256; F:flap endonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0045145; F:single-stranded DNA specific 5'-3' exodeoxyribonuclease activity; ISS:UniProtKB.
									GO:0006310; P:DNA recombination; ISS:UniProtKB.::GO:0006298; P:mismatch repair; ISS:UniProtKB.
200	P28706	1112	RAD13_SCHPO DNA repair protein rad13 OS=Schiz...	265	0.00000000000002	78.6	26	46	GO:0005634; C:nucleus; IDA:PomBase.
									GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
									GO:0006295; P:nucleotide-excision repair, DNA incision, 3'-to lesion; TAS:PomBase.
201	Q8L6Z7	735	EXO1_ARATH Exonuclease 1 OS=Arabidopsis thali...	362	0.000000000000003	80.9	27	45	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
202	Q64MA3	629	GENL1_ORYSJ Flap endonuclease GEN-like 1 OS=O...	243	0.000000000000004	80.5	27	45	GO:0005634; C:nucleus; IDA:Gramene.
									GO:0003690; F:double-stranded DNA binding; IDA:Gramene.::GO:0048256; F:flap endonuclease activity; IDA:Gramene.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003697; F:single-stranded DNA binding; IDA:Gramene.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0009555; P:pollen development; IMP:Gramene.
203	P28715	1186	ERCC5_HUMAN DNA repair protein complementing ...	132	0.0000002	56.6	29	51	GO:0005654; C:nucleoplasm; TAS:Reactome.
									GO:0000405; F:bubble DNA binding; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0004520; F:endodeoxyribonuclease activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.::GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
									GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0000718; P:nucleotide-excision repair, DNA damage removal; TAS:Reactome.::GO:0006295; P:nucleotide-excision repair, DNA incision, 3'-to lesion; IDA:UniProtKB.::GO:0010225; P:response to UV-C; IMP:UniProtKB.::GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:UniProtKB.::GO:0009650; P:UV protection; IGI:MGI.
204	Q8BMI4	908	GEN_MOUSE Flap endonuclease GEN homolog 1 OS=...	285	0.00000000000001	79.3	27	44	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
205	Q9VRJ0	726	GEN_DROME Flap endonuclease GEN OS=Drosophila...	248	0.00000000000001	79	27	43	GO:0005634; C:nucleus; IDA:UniProtKB.
									GO:0035312; F:5'-3' exodeoxyribonuclease activity; IDA:FlyBase.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0008311; F:double-stranded DNA specific 3'-5' exodeoxyribonuclease activity; IDA:FlyBase.::GO:0004520; F:endodeoxyribonuclease activity; IDA:FlyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008310; F:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; IDA:FlyBase.
									GO:0000737; P:DNA catabolic process, endonucleolytic; IDA:FlyBase.::GO:0000738; P:DNA catabolic process, exonucleolytic; IDA:FlyBase.::GO:0006302; P:double-strand break repair; IMP:FlyBase.
206	Q9ATY5	1479	UVH3_ARATH DNA repair protein UVH3 OS=Arabido...	119	0.00000001	60.5	29	55	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:TAIR.::GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
									GO:0010213; P:non-photoreactive DNA repair; IMP:TAIR.::GO:0006289; P:nucleotide-excision repair; IEA:InterPro.::GO:0009408; P:response to heat; IMP:TAIR.::GO:0010224; P:response to UV-B; IGI:TAIR.
207	P14629	1196	ERCC5_XENLA DNA repair protein complementing ...	162	0.000001	54.3	25	49	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
									GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
208	P53695	571	EXO1_SCHPO Exodeoxyribonuclease 1 OS=Schizosa...	255	0.00000000000002	78.6	28	45	GO:0005634; C:nucleus; IDA:PomBase.::GO:0005819; C:spindle; IDA:PomBase.
									GO:0008409; F:5'-3' exonuclease activity; IMP:PomBase.::GO:0017108; F:5'-flap endonuclease activity; ISS:PomBase.::GO:0003690; F:double-stranded DNA binding; IDA:PomBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0043570; P:maintenance of DNA repeat elements; IMP:PomBase.::GO:0000706; P:meiotic DNA double-strand break processing; TAS:PomBase.::GO:0006298; P:mismatch repair; IMP:PomBase.::GO:0006312; P:mitotic recombination; TAS:PomBase.::GO:0000723; P:telomere maintenance; TAS:PomBase.
209	Q9QZ11	837	EXO1_MOUSE Exonuclease 1 OS=Mus musculus (Mou...	316	0.00000000000002	78.6	28	43	GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0048256; F:flap endonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0045145; F:single-stranded DNA specific 5'-3' exodeoxyribonuclease activity; ISS:UniProtKB.::GO:0043566; F:structure-specific DNA binding; IDA:MGI.
									GO:0002455; P:humoral immune response mediated by circulating immunoglobulin; IMP:MGI.::GO:0045190; P:isotype switching; IMP:MGI.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0006298; P:mismatch repair; ISS:UniProtKB.::GO:0016446; P:somatic hypermutation of immunoglobulin genes; IMP:MGI.
210	Q9UQ84	846	EXO1_HUMAN Exonuclease 1 OS=Homo sapiens (Hum...	317	0.0000000000002	75.9	29	44	GO:0005634; C:nucleus; IDA:UniProtKB.
									GO:0051908; F:double-stranded DNA specific 5'-3' exodeoxyribonuclease activity; IDA:UniProtKB.::GO:0048256; F:flap endonuclease activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004523; F:ribonuclease H activity; TAS:ProtInc.::GO:0045145; F:single-stranded DNA specific 5'-3' exodeoxyribonuclease activity; IDA:UniProtKB.
									GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0006298; P:mismatch repair; IDA:UniProtKB.
211	Q29FC1	754	GEN_DROPS Flap endonuclease GEN OS=Drosophila...	247	0.0000000000005	74.3	26	41	GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0035312; F:5'-3' exodeoxyribonuclease activity; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0008311; F:double-stranded DNA specific 3'-5' exodeoxyribonuclease activity; ISS:UniProtKB.::GO:0004520; F:endodeoxyribonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008310; F:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; ISS:UniProtKB.
									GO:0000737; P:DNA catabolic process, endonucleolytic; ISS:UniProtKB.::GO:0000738; P:DNA catabolic process, exonucleolytic; ISS:UniProtKB.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.

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