Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YKL092C
Length:
1104
Number of sequences:
5887
Description:
YKL092C BUD2 SGDID:S000001575, Chr XI from 269459-266145, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q55AR6    920   NFAA_DICDI Neurofibromin-A OS=Dictyostelium d...2190.0000000000002     78.2     29     52GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005099; F:Ras GTPase activator activity; ISS:dictyBase.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0030833; P:regulation of actin filament polymerization; IMP:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0051896; P:regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro.
32P97526    2820   NF1_RAT Neurofibromin OS=Rattus norvegicus (R...1890.000000003     65.1     28     49GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; IDA:HGNC.::GO:0014069; C:postsynaptic density; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD.
GO:0008017; F:microtubule binding; IDA:MGI.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0045545; F:syndecan binding; IPI:RGD.
GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; ISS:HGNC.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0045765; P:regulation of angiogenesis; ISS:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0045664; P:regulation of neuron differentiation; IMP:RGD.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC.
33Q22720    629   GAP1_CAEEL Ras GTPase-activating protein gap-...1390.00000003     61.6     29     49GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; NAS:UniProtKB.
GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
34Q54K32    822   RGAA_DICDI Ras GTPase-activating-like protein...2350.0000002     59.3     23     41GO:0005938; C:cell cortex; TAS:dictyBase.::GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; ISS:dictyBase.::GO:0048365; F:Rac GTPase binding; IPI:dictyBase.::GO:0005099; F:Ras GTPase activator activity; IDA:dictyBase.
GO:0000910; P:cytokinesis; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
35Q04690    2841   NF1_MOUSE Neurofibromin OS=Mus musculus (Mous...2060.0000003     58.9     25     45GO:0005737; C:cytoplasm; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005515; F:protein binding; IPI:MGI.::GO:0005099; F:Ras GTPase activator activity; IGI:MGI.
GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0030325; P:adrenal gland development; IMP:MGI.::GO:0048844; P:artery morphogenesis; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.::GO:0021987; P:cerebral cortex development; IMP:MGI.::GO:0030199; P:collagen fibril organization; IMP:MGI.::GO:0021897; P:forebrain astrocyte development; IMP:MGI.::GO:0048853; P:forebrain morphogenesis; IMP:MGI.::GO:0007507; P:heart development; IMP:MGI.::GO:0001889; P:liver development; IMP:MGI.::GO:0000165; P:MAPK cascade; IMP:MGI.::GO:0001656; P:metanephros development; IMP:MGI.::GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.::GO:0016525; P:negative regulation of angiogenesis; IGI:MGI.::GO:0048712; P:negative regulation of astrocyte differentiation; IMP:MGI.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; IMP:MGI.::GO:0046929; P:negative regulation of neurotransmitter secretion; IMP:MGI.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.::GO:0035021; P:negative regulation of Rac protein signal transduction; IGI:MGI.::GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:MGI.::GO:0021915; P:neural tube development; IGI:MGI.::GO:0001649; P:osteoblast differentiation; IMP:MGI.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:MGI.::GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IMP:MGI.::GO:0045124; P:regulation of bone resorption; IMP:MGI.::GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.::GO:0048745; P:smooth muscle tissue development; IMP:MGI.::GO:0021510; P:spinal cord development; IMP:MGI.::GO:0048485; P:sympathetic nervous system development; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI.
36P21359    2839   NF1_HUMAN Neurofibromin OS=Homo sapiens (Huma...2060.0000007     57.8     24     45GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; ISS:HGNC.::GO:0030425; C:dendrite; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; ISS:HGNC.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0005099; F:Ras GTPase activator activity; IDA:HGNC.
GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0043535; P:regulation of blood vessel endothelial cell migration; IMP:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC.
37Q3UQ44    1575   IQGA2_MOUSE Ras GTPase-activating-like protei...1420.0005     48.1     24     46GO:0005622; C:intracellular; IEA:InterPro.::GO:0005902; C:microvillus; IDA:MGI.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
38P19158    3079   IRA2_YEAST Inhibitory regulator protein IRA2 ...2050.0006     48.1     21     49GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005099; F:Ras GTPase activator activity; IDA:SGD.
GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:SGD.::GO:0006950; P:response to stress; IMP:SGD.::GO:0007165; P:signal transduction; IEA:InterPro.
39O00899    860   GAPA_DICDI Ras GTPase-activating-like protein...830.0006     47.8     33     57GO:0005622; C:intracellular; IEA:InterPro.
GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006972; P:hyperosmotic response; IEP:dictyBase.::GO:0006979; P:response to oxidative stress; IEP:dictyBase.::GO:0019953; P:sexual reproduction; IEP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
40P18963    3092   IRA1_YEAST Inhibitory regulator protein IRA1 ...1350.0007     47.8     22     51GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005099; F:Ras GTPase activator activity; IMP:SGD.
GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:SGD.::GO:0045761; P:regulation of adenylate cyclase activity; IMP:SGD.::GO:0007165; P:signal transduction; IEA:InterPro.
41Q13576    1575   IQGA2_HUMAN Ras GTPase-activating-like protei...1380.002     46.6     24     45GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
42Q86VI3    1631   IQGA3_HUMAN Ras GTPase-activating-like protei...1640.02     42.7     20     43
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
43Q9VZ08    1712   RME6_DROME Receptor-mediated endocytosis prot...1580.038     42     25     45GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
44A2RV61    1452   GAPD1_XENLA GTPase-activating protein and VPS...1610.052     41.6     23     46GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
45Q9JKF1    1657   IQGA1_MOUSE Ras GTPase-activating-like protei...1490.13     40     24     43GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
46Q14C86    1478   GAPD1_HUMAN GTPase-activating protein and VPS...1100.16     40     25     48GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; IMP:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; IMP:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
47A5D794    1413   GAPD1_BOVIN GTPase-activating protein and VPS...1100.2     39.7     25     48GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
48Q6PAR5    1458   GAPD1_MOUSE GTPase-activating protein and VPS...1100.2     39.7     25     48GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; IMP:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; IMP:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
49P46940    1657   IQGA1_HUMAN Ras GTPase-activating-like protei...1480.23     39.3     21     43GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005737; C:cytoplasm; IDA:HPA.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO:0005516; F:calmodulin binding; TAS:ProtInc.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
50Q8BX07    270   CTDS2_MOUSE Carboxy-terminal domain RNA polym...1181.8     35.8     28     46GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
51A0PJ24    2216   L_BCNVU RNA-directed RNA polymerase L OS=(BCN...915.6     35     29     47GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.::GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
GO:0032774; P:RNA biosynthetic process; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.
52Q9U6A9    655   NOG1_TRYBB Nucleolar GTP-binding protein 1 OS...1186.2     34.7     21     44GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
53Q9PVZ4    1362   INSR_XENLA Insulin receptor OS=Xenopus laevis...627.1     34.7     32     56GO:0005887; C:integral to plasma membrane; TAS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043559; F:insulin binding; IDA:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.::GO:0005009; F:insulin-activated receptor activity; IDA:UniProtKB.::GO:0043548; F:phosphatidylinositol 3-kinase binding; ISS:UniProtKB.::GO:0051425; F:PTB domain binding; IPI:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0051290; P:protein heterotetramerization; IDA:UniProtKB.
54Q6FVT7    431   MMM1_CANGA Maintenance of mitochondrial morph...467.6     33.9     39     61GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
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