Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YKL032C
Length:
597
Number of sequences:
5887
Description:
YKL032C IXR1 SGDID:S000001515, Chr XI from 381858-380065, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P33417    597   IXR1_YEAST Intrastrand cross-link recognition...5970     1186     100     100GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003684; F:damaged DNA binding; IDA:SGD.::GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
GO:0071456; P:cellular response to hypoxia; IMP:SGD.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
2Q02486    183   ABF2_YEAST ARS-binding factor 2, mitochondria...1614e-31     124     37     66GO:0000262; C:mitochondrial chromosome; IDA:SGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008301; F:DNA binding, bending; IDA:SGD.
GO:0090139; P:mitochondrial DNA packaging; IMP:SGD.::GO:0000002; P:mitochondrial genome maintenance; IMP:SGD.::GO:0000001; P:mitochondrion inheritance; IMP:SGD.
3Q196Z2    201   VF401_IIV3 High mobility group protein homolo...1340.00000000008     65.5     31     49GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
4Q9SUP7    456   HMGB6_ARATH High mobility group B protein 6 O...652.1     35     28     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IDA:TAIR.
5Q9T012    446   HMG13_ARATH High mobility group B protein 13 ...1960.18     38.1     22     39GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
6P40618    202   HMGB3_CHICK High mobility group protein B3 OS...510.12     38.1     33     55GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
7Q32L31    200   HMGB3_BOVIN High mobility group protein B3 OS...820.25     37     27     46GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008301; F:DNA binding, bending; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
GO:0006310; P:DNA recombination; IDA:UniProtKB.
8O15347    200   HMGB3_HUMAN High mobility group protein B3 OS...820.55     35.8     27     45GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008301; F:DNA binding, bending; ISS:UniProtKB.::GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO:0006310; P:DNA recombination; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; TAS:ProtInc.
9P07746    204   HMGT_ONCMY High mobility group-T protein OS=O...610.017     40.8     33     57GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
10O54879    200   HMGB3_MOUSE High mobility group protein B3 OS...820.21     37.4     27     48GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0045578; P:negative regulation of B cell differentiation; IDA:MGI.::GO:0045638; P:negative regulation of myeloid cell differentiation; IDA:MGI.
11P12682    215   HMGB1_PIG High mobility group protein B1 OS=S...611.3     35     31     49GO:0000793; C:condensed chromosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006288; P:base-excision repair, DNA ligation; ISS:UniProtKB.::GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; ISS:UniProtKB.
12P63159    215   HMGB1_RAT High mobility group protein B1 OS=R...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
GO:0008097; F:5S rRNA binding; IDA:RGD.::GO:0003681; F:bent DNA binding; IDA:MGI.::GO:0000402; F:crossed form four-way junction DNA binding; IDA:MGI.::GO:0005125; F:cytokine activity; IDA:UniProtKB.::GO:0008301; F:DNA binding, bending; IDA:RGD.::GO:0003690; F:double-stranded DNA binding; IDA:RGD.::GO:0051861; F:glycolipid binding; IDA:RGD.::GO:0008201; F:heparin binding; IDA:RGD.::GO:0000401; F:open form four-way junction DNA binding; IDA:MGI.::GO:0042277; F:peptide binding; IDA:RGD.::GO:0046983; F:protein dimerization activity; IDA:RGD.::GO:0050786; F:RAGE receptor binding; IPI:UniProtKB.::GO:0003697; F:single-stranded DNA binding; IDA:RGD.::GO:0008134; F:transcription factor binding; IDA:RGD.
GO:0031532; P:actin cytoskeleton reorganization; IMP:RGD.::GO:0000902; P:cell morphogenesis; IMP:RGD.::GO:0071347; P:cellular response to interleukin-1; IEP:RGD.::GO:0006935; P:chemotaxis; IDA:RGD.::GO:0007623; P:circadian rhythm; IEP:RGD.::GO:0032392; P:DNA geometric change; IDA:MGI.::GO:0050930; P:induction of positive chemotaxis; IDA:MGI.::GO:0050831; P:male-specific defense response to bacterium; IDA:RGD.::GO:0051450; P:myoblast proliferation; IMP:RGD.::GO:0008156; P:negative regulation of DNA replication; IDA:RGD.::GO:0031175; P:neuron projection development; IGI:UniProtKB.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; IDA:MGI.::GO:0045931; P:positive regulation of mitotic cell cycle; IDA:MGI.::GO:0033034; P:positive regulation of myeloid cell apoptotic process; IDA:RGD.::GO:0045663; P:positive regulation of myoblast differentiation; IMP:RGD.::GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.::GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.::GO:0050727; P:regulation of inflammatory response; IDA:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0009408; P:response to heat; IEP:RGD.::GO:0032868; P:response to insulin stimulus; IEP:RGD.::GO:0034341; P:response to interferon-gamma; IMP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
13A9RA84    215   HMGB1_PAPAN High mobility group protein B1 OS...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
14P63158    215   HMGB1_MOUSE High mobility group protein B1 OS...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005615; C:extracellular space; IDA:MGI.::GO:0043005; C:neuron projection; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005625; C:soluble fraction; IDA:MGI.
GO:0010858; F:calcium-dependent protein kinase regulator activity; IDA:MGI.::GO:0005125; F:cytokine activity; IDA:MGI.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008201; F:heparin binding; IEA:UniProtKB-KW.::GO:0001786; F:phosphatidylserine binding; TAS:BHF-UCL.::GO:0030295; F:protein kinase activator activity; IDA:MGI.
GO:0001654; P:eye development; IMP:MGI.::GO:0006954; P:inflammatory response; TAS:BHF-UCL.::GO:0030324; P:lung development; IMP:MGI.::GO:2000426; P:negative regulation of apoptotic cell clearance; IDA:BHF-UCL.::GO:0045819; P:positive regulation of glycogen catabolic process; IMP:MGI.::GO:0045639; P:positive regulation of myeloid cell differentiation; IDA:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0051384; P:response to glucocorticoid stimulus; IMP:MGI.
15Q4R844    215   HMGB1_MACFA High mobility group protein B1 OS...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
16P09429    215   HMGB1_HUMAN High mobility group protein B1 OS...611.2     35     31     51GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0000793; C:condensed chromosome; IDA:UniProtKB.::GO:0005615; C:extracellular space; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0042056; F:chemoattractant activity; ISS:UniProtKB.::GO:0005125; F:cytokine activity; ISS:UniProtKB.::GO:0003684; F:damaged DNA binding; ISS:UniProtKB.::GO:0008301; F:DNA binding, bending; IMP:UniProtKB.::GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.::GO:0050786; F:RAGE receptor binding; ISS:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.::GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO:0006288; P:base-excision repair, DNA ligation; IDA:UniProtKB.::GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB.::GO:0006309; P:DNA fragmentation involved in apoptotic nuclear change; TAS:Reactome.::GO:0006265; P:DNA topological change; ISS:UniProtKB.::GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB.::GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB.::GO:0031175; P:neuron projection development; ISS:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.::GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0033151; P:V(D)J recombination; IDA:UniProtKB.
17Q08IE6    215   HMGB1_HORSE High mobility group protein B1 OS...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
18Q6YKA4    215   HMGB1_CANFA High mobility group protein B1 OS...611.2     35     31     51
19B1MTB0    215   HMGB1_CALMO High mobility group protein B1 OS...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
20B0CM99    215   HMGB1_CALJA High mobility group protein B1 OS...611.2     35     31     51GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
21P10103    215   HMGB1_BOVIN High mobility group protein B1 OS...611.2     35     31     51GO:0000793; C:condensed chromosome; ISS:AgBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0042056; F:chemoattractant activity; IDA:UniProtKB.::GO:0003684; F:damaged DNA binding; IDA:UniProtKB.::GO:0008301; F:DNA binding, bending; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0006288; P:base-excision repair, DNA ligation; ISS:AgBase.::GO:0006338; P:chromatin remodeling; NAS:UniProtKB.::GO:0002407; P:dendritic cell chemotaxis; IDA:UniProtKB.::GO:0006265; P:DNA topological change; IDA:UniProtKB.::GO:0001773; P:myeloid dendritic cell activation; IDA:UniProtKB.::GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; ISS:AgBase.::GO:0033151; P:V(D)J recombination; IDA:UniProtKB.
22Q09390    235   HMG12_CAEEL High mobility group protein 1.2 O...1260.000002     52.8     26     48GO:0005634; C:nucleus; IDA:WormBase.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0001708; P:cell fate specification; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0040025; P:vulval development; IMP:WormBase.::GO:0016055; P:Wnt receptor signaling pathway; IGI:WormBase.
23P36194    201   HMGB1_CHICK High mobility group protein B1 OS...510.32     36.6     31     53GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
24P26583    209   HMGB2_HUMAN High mobility group protein B2 OS...862.8     33.9     27     44GO:0000793; C:condensed chromosome; IDA:UniProtKB.::GO:0005615; C:extracellular space; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0043234; C:protein complex; IDA:UniProtKB.
GO:0042056; F:chemoattractant activity; IDA:UniProtKB.::GO:0003684; F:damaged DNA binding; IDA:UniProtKB.::GO:0008301; F:DNA binding, bending; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.::GO:0050786; F:RAGE receptor binding; IGI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.::GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0006288; P:base-excision repair, DNA ligation; IDA:UniProtKB.::GO:0060326; P:cell chemotaxis; IDA:UniProtKB.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB.::GO:0006309; P:DNA fragmentation involved in apoptotic nuclear change; TAS:Reactome.::GO:0006265; P:DNA topological change; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0006334; P:nucleosome assembly; NAS:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:UniProtKB.::GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.::GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.::GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:UniProtKB.::GO:0045654; P:positive regulation of megakaryocyte differentiation; IMP:UniProtKB.::GO:0032075; P:positive regulation of nuclease activity; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0033151; P:V(D)J recombination; ISS:UniProtKB.
25P40673    209   HMGB2_BOVIN High mobility group protein B2 OS...862.8     33.9     27     44GO:0000793; C:condensed chromosome; ISS:AgBase.::GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
GO:0003684; F:damaged DNA binding; IDA:UniProtKB.::GO:0008301; F:DNA binding, bending; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0006288; P:base-excision repair, DNA ligation; ISS:AgBase.::GO:0006338; P:chromatin remodeling; NAS:UniProtKB.::GO:0006265; P:DNA topological change; IDA:UniProtKB.::GO:0033151; P:V(D)J recombination; IDA:UniProtKB.
26P52925    210   HMGB2_RAT High mobility group protein B2 OS=R...793.1     33.9     30     48GO:0000793; C:condensed chromosome; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0008301; F:DNA binding, bending; ISS:UniProtKB.::GO:0003690; F:double-stranded DNA binding; TAS:RGD.::GO:0008289; F:lipid binding; IDA:RGD.::GO:0031493; F:nucleosomal histone binding; IDA:RGD.
GO:0006288; P:base-excision repair, DNA ligation; ISS:UniProtKB.::GO:0007049; P:cell cycle; IEP:RGD.::GO:0007399; P:nervous system development; IDA:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0051054; P:positive regulation of DNA metabolic process; IMP:RGD.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:RGD.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
27P17741    210   HMGB2_PIG High mobility group protein B2 OS=S...871.8     34.3     26     43GO:0000793; C:condensed chromosome; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0008301; F:DNA binding, bending; IDA:UniProtKB.
GO:0006288; P:base-excision repair, DNA ligation; ISS:UniProtKB.::GO:0006265; P:DNA topological change; IDA:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
28Q04891    613   SOX13_MOUSE Transcription factor SOX-13 OS=Mu...663.8     34.3     29     52GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
29Q9UN79    622   SOX13_HUMAN Transcription factor SOX-13 OS=Ho...664.8     33.9     29     52GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
30P40649    567   SOX13_XENLA Transcription factor Sox-13 OS=Xe...660.46     37     29     52GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
31P30681    210   HMGB2_MOUSE High mobility group protein B2 OS...866.5     32.7     27     44GO:0000793; C:condensed chromosome; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0008301; F:DNA binding, bending; ISS:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:MGI.
GO:0006288; P:base-excision repair, DNA ligation; ISS:UniProtKB.::GO:0008584; P:male gonad development; IMP:MGI.::GO:0043388; P:positive regulation of DNA binding; IDA:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0048545; P:response to steroid hormone stimulus; IMP:MGI.::GO:0007289; P:spermatid nucleus differentiation; IMP:MGI.
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