Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YKL017C
Length:
683
Number of sequences:
5887
Description:
YKL017C HCS1 SGDID:S000001500, Chr XI from 407241-405190, Genome Release 64-1-1, reverse complement, Verified ORF, "Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P34243    683   HCS1_YEAST DNA polymerase alpha-associated DN...6830     1394     100     100GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0033203; C:DNA helicase A complex; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IDA:SGD.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006273; P:lagging strand elongation; IC:SGD.
2O94247    660   HCS1_SCHPO DNA polymerase alpha-associated DN...6751e-125     394     36     59GO:0005829; C:cytosol; IDA:PomBase.::GO:0033203; C:DNA helicase A complex; ISS:PomBase.::GO:0043596; C:nuclear replication fork; IC:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; ISS:PomBase.
GO:0006273; P:lagging strand elongation; ISS:PomBase.
3P38935    993   SMBP2_HUMAN DNA-binding protein SMUBP-2 OS=Ho...6825e-116     378     35     57GO:0030424; C:axon; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0030426; C:growth cone; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IDA:UniProtKB.::GO:0032575; F:ATP-dependent 5'-3' RNA helicase activity; IDA:UniProtKB.::GO:0043022; F:ribosome binding; IDA:UniProtKB.::GO:0003697; F:single-stranded DNA binding; TAS:ProtInc.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0000049; F:tRNA binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0006310; P:DNA recombination; TAS:ProtInc.::GO:0006281; P:DNA repair; TAS:ProtInc.::GO:0006260; P:DNA replication; TAS:ProtInc.::GO:0051260; P:protein homooligomerization; IPI:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006412; P:translation; NAS:UniProtKB.
4Q60560    989   SMBP2_MESAU DNA-binding protein SMUBP-2 OS=Me...6742e-109     360     35     56GO:0030424; C:axon; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; ISS:UniProtKB.::GO:0032575; F:ATP-dependent 5'-3' RNA helicase activity; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0043621; F:protein self-association; ISS:UniProtKB.::GO:0043022; F:ribosome binding; ISS:UniProtKB.::GO:0000049; F:tRNA binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5P40694    993   SMBP2_MOUSE DNA-binding protein SMUBP-2 OS=Mu...6725e-108     356     35     56GO:0030424; C:axon; IDA:UniProtKB.::GO:0030426; C:growth cone; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; ISS:UniProtKB.::GO:0032575; F:ATP-dependent 5'-3' RNA helicase activity; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0043621; F:protein self-association; ISS:UniProtKB.::GO:0043022; F:ribosome binding; IDA:UniProtKB.::GO:0000049; F:tRNA binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006412; P:translation; NAS:UniProtKB.
6Q9EQN5    988   SMBP2_RAT DNA-binding protein SMUBP-2 OS=Ratt...6728e-106     350     35     56GO:0030424; C:axon; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; ISS:UniProtKB.::GO:0032575; F:ATP-dependent 5'-3' RNA helicase activity; ISS:UniProtKB.::GO:0003677; F:DNA binding; IDA:RGD.::GO:0043621; F:protein self-association; ISS:UniProtKB.::GO:0043022; F:ribosome binding; ISS:UniProtKB.::GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:RGD.::GO:0000049; F:tRNA binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
7Q57568    663   Y104_METJA Uncharacterized ATP-dependent heli...5607e-76     262     34     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
8Q9HEH1    1093   RENT1_NEUCR Regulator of nonsense transcripts...6121e-56     213     30     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
9Q09820    925   RENT1_SCHPO Regulator of nonsense transcripts...5672e-56     210     29     51GO:0005829; C:cytosol; IDA:PomBase.
GO:0005524; F:ATP binding; IC:PomBase.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:PomBase.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0002184; P:cytoplasmic translational termination; NAS:PomBase.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:PomBase.
10Q9EPU0    1124   RENT1_MOUSE Regulator of nonsense transcripts...5618e-54     204     30     48GO:0000785; C:chromatin; ISS:HGNC.::GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:HGNC.::GO:0003682; F:chromatin binding; ISS:HGNC.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; ISS:HGNC.::GO:0006281; P:DNA repair; ISS:HGNC.::GO:0006260; P:DNA replication; ISS:HGNC.::GO:0009048; P:dosage compensation by inactivation of X chromosome; IMP:MGI.::GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.::GO:0006449; P:regulation of translational termination; ISS:HGNC.
11Q92900    1129   RENT1_HUMAN Regulator of nonsense transcripts...5619e-54     204     30     48GO:0000785; C:chromatin; IDA:HGNC.::GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0035145; C:exon-exon junction complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; IDA:HGNC.::GO:0003682; F:chromatin binding; IDA:HGNC.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003723; F:RNA binding; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IMP:HGNC.::GO:0006281; P:DNA repair; IDA:HGNC.::GO:0006260; P:DNA replication; IMP:HGNC.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0071044; P:histone mRNA catabolic process; IMP:UniProtKB.::GO:0006406; P:mRNA export from nucleus; TAS:HGNC.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IDA:UniProtKB.::GO:0006449; P:regulation of translational termination; IMP:UniProtKB.
12Q9FJR0    1254   RENT1_ARATH Regulator of nonsense transcripts...5511e-52     201     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.::GO:0009744; P:response to sucrose stimulus; IGI:TAIR.::GO:0016246; P:RNA interference; IGI:TAIR.::GO:0010182; P:sugar mediated signaling pathway; IMP:TAIR.
13P30771    971   NAM7_YEAST ATP-dependent helicase NAM7 OS=Sac...5338e-52     197     31     50GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005844; C:polysome; TAS:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; TAS:SGD.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030466; P:chromatin silencing at silent mating-type cassette; IGI:SGD.::GO:0008298; P:intracellular mRNA localization; IMP:SGD.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IMP:SGD.::GO:0016567; P:protein ubiquitination; IDA:SGD.::GO:0006449; P:regulation of translational termination; TAS:SGD.
14Q9VYS3    1180   RENT1_DROME Regulator of nonsense transcripts...4642e-50     194     31     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:FlyBase.
15Q54I89    1331   RENT1_DICDI Regulator of nonsense transcripts...4672e-49     191     31     52GO:0005737; C:cytoplasm; ISS:dictyBase.
GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:dictyBase.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:dictyBase.
16O76512    1069   RENT1_CAEEL Regulator of nonsense transcripts...4603e-49     190     31     50GO:0005737; C:cytoplasm; IDA:WormBase.::GO:0005634; C:nucleus; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0051721; F:protein phosphatase 2A binding; IPI:WormBase.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030538; P:embryonic genitalia morphogenesis; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IGI:WormBase.::GO:0016246; P:RNA interference; IMP:WormBase.
17Q92355    1687   SEN1_SCHPO Helicase sen1 OS=Schizosaccharomyc...5951e-47     186     30     47GO:0035649; C:Nrd1 complex; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IC:PomBase.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IDA:PomBase.::GO:0032575; F:ATP-dependent 5'-3' RNA helicase activity; IDA:PomBase.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0006364; P:rRNA processing; ISS:PomBase.::GO:0043144; P:snoRNA processing; ISS:PomBase.::GO:0016180; P:snRNA processing; ISS:PomBase.::GO:0006369; P:termination of RNA polymerase II transcription; ISS:PomBase.::GO:0008033; P:tRNA processing; ISS:PomBase.
18Q98TR3    1097   RENT1_TAKRU Putative regulator of nonsense tr...5632e-44     175     29     47GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
19Q9BXT6    1211   M10L1_HUMAN Putative helicase Mov10l1 OS=Homo...4837e-43     170     30     46GO:0005622; C:intracellular; IC:UniProtKB.
GO:0005524; F:ATP binding; TAS:UniProtKB.::GO:0004004; F:ATP-dependent RNA helicase activity; NAS:UniProtKB.::GO:0000287; F:magnesium ion binding; TAS:UniProtKB.::GO:0003723; F:RNA binding; TAS:UniProtKB.
GO:0007281; P:germ cell development; IEP:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEP:UniProtKB.
20P32644    1121   ECM32_YEAST Putative ATP-dependent RNA helica...5511e-42     170     29     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005844; C:polysome; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003678; F:DNA helicase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006449; P:regulation of translational termination; IMP:SGD.
21Q99MV5    1187   M10L1_MOUSE Putative helicase Mov10l1 OS=Mus ...4852e-41     166     31     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; IDA:UniProtKB.::GO:0007517; P:muscle organ development; IDA:UniProtKB.::GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.::GO:0007283; P:spermatogenesis; ISS:UniProtKB.
22Q8GYD9    1002   SDE3_ARATH Probable RNA helicase SDE3 OS=Arab...4892e-39     159     29     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.::GO:0009616; P:virus induced gene silencing; IMP:TAIR.
23O94387    1944   YGSA_SCHPO Uncharacterized ATP-dependent heli...5787e-39     158     29     45GO:0035649; C:Nrd1 complex; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:PomBase.
GO:0006364; P:rRNA processing; ISS:PomBase.::GO:0043144; P:snoRNA processing; ISS:PomBase.::GO:0016180; P:snRNA processing; ISS:PomBase.::GO:0006369; P:termination of RNA polymerase II transcription; IEA:InterPro.::GO:0008033; P:tRNA processing; ISS:PomBase.
24Q7Z333    2677   SETX_HUMAN Probable helicase senataxin OS=Hom...5824e-37     153     28     47GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IC:UniProtKB.::GO:0003678; F:DNA helicase activity; TAS:UniProtKB.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; IDA:UniProtKB.::GO:0006396; P:RNA processing; TAS:UniProtKB.
25A2AKX3    2646   SETX_MOUSE Probable helicase senataxin OS=Mus...6641e-36     152     26     46GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0006302; P:double-strand break repair; ISS:UniProtKB.
26P23249    1004   MOV10_MOUSE Putative helicase MOV-10 OS=Mus m...5074e-36     149     28     47GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0035279; P:mRNA cleavage involved in gene silencing by miRNA; ISS:UniProtKB.
27Q0V8H6    1003   MOV10_BOVIN Putative helicase MOV-10 OS=Bos t...4875e-36     149     29     47GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0035279; P:mRNA cleavage involved in gene silencing by miRNA; ISS:UniProtKB.
28Q6ZU11    926   YD002_HUMAN Uncharacterized protein FLJ44066 ...4696e-36     149     30     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
29B6SFA4    818   MAA3_ARATH Probable helicase MAGATAMA 3 OS=Ar...1070.0004     47.4     29     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0009553; P:embryo sac development; IMP:TAIR.::GO:0010183; P:pollen tube guidance; IMP:TAIR.::GO:0009875; P:pollen-pistil interaction; IMP:TAIR.
30Q00416    2231   SEN1_YEAST Helicase SEN1 OS=Saccharomyces cer...6721e-33     142     26     43GO:0035649; C:Nrd1 complex; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; ISS:SGD.::GO:0032575; F:ATP-dependent 5'-3' RNA helicase activity; ISS:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006378; P:mRNA polyadenylation; IMP:SGD.::GO:0006364; P:rRNA processing; IMP:SGD.::GO:0043144; P:snoRNA processing; IMP:SGD.::GO:0016180; P:snRNA processing; IMP:SGD.::GO:0006369; P:termination of RNA polymerase II transcription; IMP:SGD.::GO:0008033; P:tRNA processing; IMP:SGD.
31Q86AS0    967   Y4399_DICDI Probable helicase DDB_G0274399 OS...400.027     41.6     53     68GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
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