Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YKL012W
Length:
583
Number of sequences:
5887
Description:
YKL012W PRP40 SGDID:S000001495, Chr XI from 418310-420061, Genome Release 64-1-1, Verified ORF, "U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q62940    887   NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 O...830.023     41.6     28     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005902; C:microvillus; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0006955; P:immune response; IEP:RGD.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB.
32Q9CUN6    731   SMUF1_MOUSE E3 ubiquitin-protein ligase SMURF...720.032     40.8     26     50GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; ISS:UniProtKB.::GO:0030279; P:negative regulation of ossification; IMP:MGI.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
33Q5F389    414   WWOX_CHICK WW domain-containing oxidoreductas...920.043     40     29     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
34Q9H0M0    922   WWP1_HUMAN NEDD4-like E3 ubiquitin-protein li...720.078     39.7     35     50GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB.
GO:0007417; P:central nervous system development; NAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007165; P:signal transduction; NAS:UniProtKB.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB.
35Q9PUN2    731   SMUF1_XENLA E3 ubiquitin-protein ligase SMURF...720.077     39.7     25     50GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IDA:UniProtKB.::GO:0007398; P:ectoderm development; TAS:UniProtKB.::GO:0030514; P:negative regulation of BMP signaling pathway; TAS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
36Q7ZUK7    558   WAC_DANRE WW domain-containing adapter protei...340.08     39.7     50     68GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO:0000075; P:cell cycle checkpoint; ISS:UniProtKB.::GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
37Q5U4Q0    628   WAC_XENTR WW domain-containing adapter protei...340.083     39.7     50     68GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO:0000075; P:cell cycle checkpoint; ISS:UniProtKB.::GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
38Q924H7    646   WAC_MOUSE WW domain-containing adapter protei...340.085     39.7     50     68GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IDA:MGI.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO:0000075; P:cell cycle checkpoint; ISS:UniProtKB.::GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
39Q9BTA9    647   WAC_HUMAN WW domain-containing adapter protei...340.089     39.3     50     68GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0000993; F:RNA polymerase II core binding; IDA:UniProtKB.
GO:0000075; P:cell cycle checkpoint; IMP:UniProtKB.::GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; IMP:UniProtKB.::GO:0010390; P:histone monoubiquitination; IMP:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
40Q8GSP8    371   ZYS3_CHLRE Zygote-specific protein 3 OS=Chlam...760.091     39.3     30     49GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB.
GO:0048468; P:cell development; NAS:UniProtKB.
41Q6ZUM4    889   RHG27_HUMAN Rho GTPase-activating protein 27 ...780.098     39.3     33     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; ISS:HGNC.::GO:0017124; F:SH3 domain binding; ISS:HGNC.
GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:HGNC.::GO:0006898; P:receptor-mediated endocytosis; ISS:HGNC.::GO:0007165; P:signal transduction; IEA:InterPro.
42Q06525    465   URN1_YEAST Pre-mRNA-splicing factor URN1 OS=S...760.1     39.3     34     47GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
43A2AB59    869   RHG27_MOUSE Rho GTPase-activating protein 27 ...810.11     39.3     33     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0006898; P:receptor-mediated endocytosis; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
44P46935    887   NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4...840.12     39.3     26     43GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IPI:MGI.
GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB.
45O04425    747   FCA_ARATH Flowering time control protein FCA ...300.15     38.9     53     63GO:0000785; C:chromatin; TAS:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0003723; F:RNA binding; IDA:TAIR.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0031048; P:chromatin silencing by small RNA; IMP:TAIR.::GO:0009790; P:embryo development; IGI:TAIR.::GO:0009553; P:embryo sac development; IGI:TAIR.::GO:0009908; P:flower development; IEA:UniProtKB-KW.::GO:0009909; P:regulation of flower development; IMP:TAIR.
46Q8C0D4    838   RHG12_MOUSE Rho GTPase-activating protein 12 ...382.6     34.7     39     63GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.
47P46934    1319   NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4...810.18     38.5     26     43GO:0016327; C:apicolateral plasma membrane; TAS:BHF-UCL.::GO:0005938; C:cell cortex; IDA:BHF-UCL.::GO:0000785; C:chromatin; IDA:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0000151; C:ubiquitin ligase complex; ISS:BHF-UCL.
GO:0031698; F:beta-2 adrenergic receptor binding; IDA:UniProtKB.::GO:0050815; F:phosphoserine binding; ISS:BHF-UCL.::GO:0050816; F:phosphothreonine binding; ISS:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0070063; F:RNA polymerase binding; IPI:BHF-UCL.::GO:0019871; F:sodium channel inhibitor activity; IDA:BHF-UCL.::GO:0043130; F:ubiquitin binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL.
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0044111; P:development involved in symbiotic interaction; IMP:UniProtKB.::GO:0042921; P:glucocorticoid receptor signaling pathway; IDA:BHF-UCL.::GO:0010766; P:negative regulation of sodium ion transport; IDA:UniProtKB.::GO:0010768; P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IMP:BHF-UCL.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0031175; P:neuron projection development; IEP:BHF-UCL.::GO:0046824; P:positive regulation of nucleocytoplasmic transport; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006622; P:protein targeting to lysosome; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0032801; P:receptor catabolic process; IDA:UniProtKB.::GO:0031623; P:receptor internalization; IDA:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.::GO:0051592; P:response to calcium ion; TAS:BHF-UCL.::GO:0019089; P:transmission of virus; IMP:BHF-UCL.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:BHF-UCL.
48Q9BYW2    2564   SETD2_HUMAN Histone-lysine N-methyltransferas...360.28     38.1     44     67GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
49A4IIJ3    1108   KIBRA_XENTR Protein KIBRA OS=Xenopus tropical...760.95     36.2     26     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
50Q8IWW6    846   RHG12_HUMAN Rho GTPase-activating protein 12 ...270.25     38.1     52     74GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
51Q8IX03    1113   KIBRA_HUMAN Protein KIBRA OS=Homo sapiens (Hu...380.36     37.7     50     63GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
GO:0016477; P:cell migration; IDA:UniProtKB.::GO:0035329; P:hippo signaling cascade; TAS:Reactome.::GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.::GO:0035330; P:regulation of hippo signaling cascade; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
52Q9QUR7    165   PIN1_MOUSE Peptidyl-prolyl cis-trans isomeras...1190.42     35.8     24     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006457; P:protein folding; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; IMP:MGI.::GO:0032465; P:regulation of cytokinesis; IMP:MGI.
53Q6DJR2    1171   WWC2_XENTR Protein WWC2 OS=Xenopus tropicalis...280.8     36.6     46     71
54Q6AWC2    1192   WWC2_HUMAN Protein WWC2 OS=Homo sapiens (Huma...270.82     36.6     52     67
55Q13526    163   PIN1_HUMAN Peptidyl-prolyl cis-trans isomeras...1250.92     35     25     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IDA:MGI.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0032794; F:GTPase activating protein binding; IPI:BHF-UCL.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:BHF-UCL.::GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:BHF-UCL.::GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:2000146; P:negative regulation of cell motility; IDA:BHF-UCL.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0001934; P:positive regulation of protein phosphorylation; IGI:MGI.::GO:0032321; P:positive regulation of Rho GTPase activity; IMP:BHF-UCL.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IDA:BHF-UCL.::GO:0006457; P:protein folding; IEA:UniProtKB-KW.::GO:0032465; P:regulation of cytokinesis; IMP:MGI.::GO:0007088; P:regulation of mitosis; TAS:ProtInc.::GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
56Q9BE31    847   RHG12_MACFA Rho GTPase-activating protein 12 ...270.97     36.2     48     74GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.
57Q6NXJ0    1187   WWC2_MOUSE Protein WWC2 OS=Mus musculus (Mous...271.1     36.2     52     67
58Q54UV7    890   Y0811_DICDI UPF0746 protein DDB_G0280811 OS=D...821.5     35.4     33     50
59B3LWS4    1271   KIBRA_DROAN Protein kibra OS=Drosophila anana...731.5     35.8     29     49GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0035330; P:regulation of hippo signaling cascade; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
60Q5BIN5    163   PIN1_BOVIN Peptidyl-prolyl cis-trans isomeras...1281.7     34.3     23     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006457; P:protein folding; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; ISS:AgBase.
61Q9VVI3    1007   NEDD4_DROME E3 ubiquitin-protein ligase Nedd-...323.9     34.3     41     63GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:FlyBase.
GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IDA:FlyBase.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.
GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.::GO:0045746; P:negative regulation of Notch signaling pathway; IMP:UniProtKB.::GO:0007528; P:neuromuscular junction development; IMP:FlyBase.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0002092; P:positive regulation of receptor internalization; IMP:FlyBase.::GO:0051965; P:positive regulation of synapse assembly; IMP:FlyBase.::GO:0031623; P:receptor internalization; IMP:UniProtKB.
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