Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YKL008C
Length:
418
Number of sequences:
5887
Description:
YKL008C LAC1 SGDID:S000001491, Chr XI from 428551-427295, Genome Release 64-1-1, reverse complement, Verified ORF, "Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P28496    418   LAC1_YEAST Sphingosine N-acyltransferase LAC1...4180     865     100     100GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:SGD.
GO:0046513; P:ceramide biosynthetic process; IDA:SGD.
2A6ZZV7    418   LAC1_YEAS7 Sphingosine N-acyltransferase LAC1...4180     865     100     100GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050291; F:sphingosine N-acyltransferase activity; IEA:EC.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
3A6ZSP9    411   LAG1_YEAS7 Sphingosine N-acyltransferase LAG1...3950     610     73     84GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050291; F:sphingosine N-acyltransferase activity; IEA:EC.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
4P38703    411   LAG1_YEAST Sphingosine N-acyltransferase LAG1...3950     606     73     84GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:SGD.
GO:0046513; P:ceramide biosynthetic process; IDA:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.
5O59735    384   LAC1_SCHPO Sphingosine N-acyltransferase lac1...3746e-89     281     41     57GO:0030176; C:integral to endoplasmic reticulum membrane; NAS:PomBase.::GO:0005773; C:vacuole; IMP:GOC.
GO:0050291; F:sphingosine N-acyltransferase activity; IEA:EC.
GO:0071277; P:cellular response to calcium ion; IMP:PomBase.::GO:0034605; P:cellular response to heat; IMP:PomBase.::GO:0071294; P:cellular response to zinc ion; IMP:PomBase.::GO:0046513; P:ceramide biosynthetic process; ISS:PomBase.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007009; P:plasma membrane organization; IMP:PomBase.::GO:0042493; P:response to drug; IMP:PomBase.::GO:0009636; P:response to toxin; IGI:PomBase.::GO:0007035; P:vacuolar acidification; IMP:PomBase.::GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; ISS:PomBase.
6P78970    390   LAG1_SCHPO Sphingosine N-acyltransferase lag1...3011e-45     167     39     55GO:0030176; C:integral to endoplasmic reticulum membrane; NAS:PomBase.::GO:0005773; C:vacuole; IGI:GOC.
GO:0050291; F:sphingosine N-acyltransferase activity; IEA:EC.
GO:0046513; P:ceramide biosynthetic process; ISS:PomBase.::GO:0042493; P:response to drug; IMP:PomBase.::GO:0009636; P:response to toxin; IMP:PomBase.::GO:0007035; P:vacuolar acidification; IGI:PomBase.
7Q6NQI8    308   LAG13_ARATH LAG1 longevity assurance homolog ...2503e-17     85.5     32     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0050291; F:sphingosine N-acyltransferase activity; IGI:TAIR.
GO:0042761; P:very long-chain fatty acid biosynthetic process; IGI:TAIR.
8Q6EUN0    309   ASCL1_ORYSJ ASC1-like protein 1 OS=Oryza sati...2450.0000000000002     74.3     28     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
9Q9LDF2    310   LAG11_ARATH LAG1 longevity assurance homolog ...3010.0000000000003     73.9     27     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
10Q9D6J1    393   CERS4_MOUSE Ceramide synthase 4 OS=Mus muscul...2540.0000000000009     72.8     26     41GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:MGI.
GO:0046513; P:ceramide biosynthetic process; IDA:MGI.
11Q9LJK3    296   LAG12_ARATH LAG1 longevity assurance homolog ...2400.000000000004     70.1     25     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0050291; F:sphingosine N-acyltransferase activity; IMP:TAIR.
GO:0042759; P:long-chain fatty acid biosynthetic process; IMP:TAIR.::GO:0002238; P:response to molecule of fungal origin; IMP:TAIR.
12Q8W4Y5    303   ASCL_SOLLC ASC1-like protein OS=Solanum lycop...2470.00000000001     68.9     28     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
13Q5E9R6    393   CERS4_BOVIN Ceramide synthase 4 OS=Bos taurus...2320.00000000005     67.8     28     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
14Q6YWS8    303   ASCL2_ORYSJ ASC1-like protein 2 OS=Oryza sati...2380.00000000005     67     29     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
15Q96G23    380   CERS2_HUMAN Ceramide synthase 2 OS=Homo sapie...1970.00000002     59.3     24     49GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IDA:HPA.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.
16P27544    350   CERS1_HUMAN Ceramide synthase 1 OS=Homo sapie...2020.00000003     58.5     27     44GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; ISS:HGNC.
GO:0050291; F:sphingosine N-acyltransferase activity; ISS:HGNC.
GO:0046513; P:ceramide biosynthetic process; ISS:HGNC.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
17Q3ZBF8    380   CERS2_BOVIN Ceramide synthase 2 OS=Bos taurus...1970.0000001     57     23     49GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
18P27545    350   CERS1_MOUSE Ceramide synthase 1 OS=Mus muscul...1990.000001     53.5     26     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:HGNC.
GO:0050291; F:sphingosine N-acyltransferase activity; IDA:HGNC.
GO:0046513; P:ceramide biosynthetic process; IDA:HGNC.
19Q9HA82    394   CERS4_HUMAN Ceramide synthase 4 OS=Homo sapie...2270.000002     53.5     26     44GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.
20Q84QC0    284   ASCL3_ORYSJ ASC1-like protein 3 OS=Oryza sati...2370.000002     52.4     26     45GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
21Q924Z4    380   CERS2_MOUSE Ceramide synthase 2 OS=Mus muscul...1970.000009     51.2     20     46GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:MGI.
GO:0046513; P:ceramide biosynthetic process; IDA:MGI.
22Q6DED0    373   TR1L1_XENLA Translocating chain-associated me...1740.0001     47.8     24     45GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
23Q15035    370   TRAM2_HUMAN Translocating chain-associated me...1850.0004     45.8     26     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0032964; P:collagen biosynthetic process; IMP:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
24Q9D6K9    414   CERS5_MOUSE Ceramide synthase 5 OS=Mus muscul...2250.0006     45.4     26     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; ISS:HGNC.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:HGNC.
GO:0046513; P:ceramide biosynthetic process; IDA:HGNC.
25Q9M6A3    308   ASC1_SOLLC Protein ASC1 OS=Solanum lycopersic...1660.001     44.7     30     49GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
26Q8QZR0    363   TR1L1_MOUSE Translocating chain-associated me...1110.001     44.7     26     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
27Q924Z5    370   TRAM2_MOUSE Translocating chain-associated me...2030.001     44.7     27     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
28Q8N5B7    392   CERS5_HUMAN Ceramide synthase 5 OS=Homo sapie...2340.001     44.3     28     48GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:HGNC.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:HGNC.
GO:0046513; P:ceramide biosynthetic process; IDA:HGNC.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
29Q6ZMG9    384   CERS6_HUMAN Ceramide synthase 6 OS=Homo sapie...1990.002     43.9     26     45GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome.
30Q01685    374   TRAM1_CANFA Translocating chain-associated me...1120.025     40.4     27     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
31Q8C172    384   CERS6_MOUSE Ceramide synthase 6 OS=Mus muscul...1700.043     39.7     25     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0050291; F:sphingosine N-acyltransferase activity; IDA:MGI.
GO:0046513; P:ceramide biosynthetic process; IDA:MGI.
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