Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YJR138W
Length:
1584
Number of sequences:
5887
Description:
YJR138W IML1 SGDID:S000003899, Chr X from 684567-689321, Genome Release 64-1-1, Verified ORF, "Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal CDC48-like domain and a C-terminal DEP domain; central region is readily accessible to proteases"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q9Y2I7    2098   FYV1_HUMAN 1-phosphatidylinositol 3-phosphate...1760.0001     50.8     26     47GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; TAS:HGNC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.::GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
32Q3LAC4    1598   PREX2_MOUSE Phosphatidylinositol 3,4,5-trisph...780.29     39.7     23     53GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
33Q70Z35    1606   PREX2_HUMAN Phosphatidylinositol 3,4,5-trisph...1050.067     41.6     26     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:MGI.
GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
34Q8TCU6    1659   PREX1_HUMAN Phosphatidylinositol 3,4,5-trisph...560.0004     48.9     36     59GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.::GO:0005886; C:plasma membrane; TAS:UniProtKB.
GO:0019899; F:enzyme binding; TAS:UniProtKB.::GO:0005543; F:phospholipid binding; IDA:UniProtKB.::GO:0005100; F:Rho GTPase activator activity; TAS:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:UniProtKB.
GO:0030041; P:actin filament polymerization; TAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0042119; P:neutrophil activation; TAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0006801; P:superoxide metabolic process; TAS:UniProtKB.
35Q5R9A7    872   GP155_PONAB Integral membrane protein GPR155 ...840.0002     49.7     33     56GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0055085; P:transmembrane transport; IEA:InterPro.
36Q05AS8    732   DVL2_XENTR Segment polarity protein dishevell...870.0003     49.3     28     51GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0035253; C:ciliary rootlet; ISS:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0046875; F:ephrin receptor binding; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0045545; F:syndecan binding; ISS:UniProtKB.
GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.::GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0060027; P:convergent extension involved in gastrulation; ISS:UniProtKB.::GO:0009950; P:dorsal/ventral axis specification; ISS:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; ISS:UniProtKB.::GO:0001843; P:neural tube closure; ISS:UniProtKB.::GO:0022008; P:neurogenesis; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.::GO:0050821; P:protein stabilization; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; ISS:UniProtKB.
37Q69ZK0    1650   PREX1_MOUSE Phosphatidylinositol 3,4,5-trisph...560.0004     48.9     36     59GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
38Q9Z1T6    2097   FYV1_MOUSE 1-phosphatidylinositol 3-phosphate...1760.0004     49.3     25     46GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
39Q60838    736   DVL2_MOUSE Segment polarity protein dishevell...1200.001     47.4     23     44GO:0045177; C:apical part of cell; IDA:MGI.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IDA:MGI.::GO:0005856; C:cytoskeleton; NAS:BHF-UCL.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IMP:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; NAS:BHF-UCL.
GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019904; F:protein domain specific binding; IPI:MGI.::GO:0043621; F:protein self-association; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0021535; P:cell migration in hindbrain; IBA:RefGenome.::GO:0034613; P:cellular protein localization; IDA:MGI.::GO:0090103; P:cochlea morphogenesis; IGI:MGI.::GO:0022007; P:convergent extension involved in neural plate elongation; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IMP:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.::GO:0061098; P:positive regulation of protein tyrosine kinase activity; IGI:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0007379; P:segment specification; IMP:MGI.
40Q61062    716   DVL3_MOUSE Segment polarity protein dishevell...910.001     47     25     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
41Q92997    716   DVL3_HUMAN Segment polarity protein dishevell...910.002     46.6     25     48GO:0005938; C:cell cortex; IBA:RefGenome.
GO:0008013; F:beta-catenin binding; IDA:BHF-UCL.::GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0002020; F:protease binding; IPI:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IDA:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0060026; P:convergent extension; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0003148; P:outflow tract septum morphogenesis; IBA:RefGenome.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0043507; P:positive regulation of JUN kinase activity; IMP:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
42O14641    736   DVL2_HUMAN Segment polarity protein dishevell...870.002     46.6     25     49GO:0045177; C:apical part of cell; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IBA:RefGenome.
GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0044340; P:canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; IDA:BHF-UCL.::GO:0021535; P:cell migration in hindbrain; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0035329; P:hippo signaling cascade; TAS:Reactome.::GO:0001843; P:neural tube closure; ISS:BHF-UCL.::GO:0003151; P:outflow tract morphogenesis; ISS:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0007379; P:segment specification; ISS:BHF-UCL.::GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB.
43Q7Z3F1    870   GP155_HUMAN Integral membrane protein GPR155 ...710.002     46.6     34     56GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0055085; P:transmembrane transport; IEA:InterPro.
44P51142    736   DVL2_XENLA Segment polarity protein dishevell...870.011     44.3     24     48GO:0005938; C:cell cortex; IDA:MGI.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0035253; C:ciliary rootlet; IDA:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0046875; F:ephrin receptor binding; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0045545; F:syndecan binding; IPI:UniProtKB.
GO:0032862; P:activation of Rho GTPase activity; IMP:UniProtKB.::GO:0009948; P:anterior/posterior axis specification; IMP:UniProtKB.::GO:0060070; P:canonical Wnt receptor signaling pathway; IGI:BHF-UCL.::GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0060027; P:convergent extension involved in gastrulation; IMP:UniProtKB.::GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0001736; P:establishment of planar polarity; IMP:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; IMP:UniProtKB.::GO:0001843; P:neural tube closure; IMP:UniProtKB.::GO:0022008; P:neurogenesis; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.::GO:0051260; P:protein homooligomerization; IPI:UniProtKB.::GO:0050821; P:protein stabilization; IMP:UniProtKB.
45Q6DKE2    717   DVL3_XENLA Segment polarity protein dishevell...910.011     43.9     24     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008013; F:beta-catenin binding; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; IMP:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
46B1WAP7    713   DVL3_XENTR Segment polarity protein dishevell...910.017     43.5     24     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008013; F:beta-catenin binding; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
47P51141    695   DVL1_MOUSE Segment polarity protein dishevell...820.049     42     23     48GO:0030424; C:axon; IDA:MGI.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IDA:MGI.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; NAS:BHF-UCL.::GO:0045202; C:synapse; IDA:MGI.::GO:0019717; C:synaptosome; IDA:MGI.
GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0048675; P:axon extension; IDA:MGI.::GO:0007411; P:axon guidance; IDA:MGI.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI.::GO:0090103; P:cochlea morphogenesis; IGI:MGI.::GO:0048668; P:collateral sprouting; IDA:MGI.::GO:0022007; P:convergent extension involved in neural plate elongation; IGI:MGI.::GO:0031122; P:cytoplasmic microtubule organization; IDA:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001933; P:negative regulation of protein phosphorylation; IGI:MGI.::GO:0007269; P:neurotransmitter secretion; IGI:MGI.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; IMP:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0060134; P:prepulse inhibition; IMP:MGI.::GO:0035372; P:protein localization to microtubule; IGI:MGI.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IMP:MGI.::GO:0035176; P:social behavior; IMP:MGI.
48Q9WVB9    695   DVL1_RAT Segment polarity protein dishevelled...820.05     42     23     48GO:0030424; C:axon; IDA:RGD.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0015630; C:microtubule cytoskeleton; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IBA:RefGenome.
GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0048365; F:Rac GTPase binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome.
49O14640    695   DVL1_HUMAN Segment polarity protein dishevell...820.051     42     23     48GO:0030424; C:axon; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; ISS:BHF-UCL.::GO:0019717; C:synaptosome; ISS:BHF-UCL.
GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.::GO:0006469; P:negative regulation of protein kinase activity; IDA:BHF-UCL.::GO:0021915; P:neural tube development; IEP:BHF-UCL.::GO:0007269; P:neurotransmitter secretion; ISS:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0034504; P:protein localization to nucleus; IMP:BHF-UCL.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome.::GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB.
50Q5IS48    670   DVL1_PANTR Segment polarity protein dishevell...820.058     41.6     23     48GO:0030424; C:axon; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IBA:RefGenome.
GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome.
51Q9Z1C8    926   RPGF3_RAT Rap guanine nucleotide exchange fac...710.071     41.6     31     52GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
52P51140    623   DSH_DROME Segment polarity protein dishevelle...810.1     40.8     21     48GO:0005912; C:adherens junction; TAS:FlyBase.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:FlyBase.
GO:0005112; F:Notch binding; NAS:FlyBase.::GO:0070300; F:phosphatidic acid binding; IDA:FlyBase.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0048675; P:axon extension; IMP:FlyBase.::GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0007394; P:dorsal closure, elongation of leading edge cells; IMP:FlyBase.::GO:0048730; P:epidermis morphogenesis; IMP:FlyBase.::GO:0045198; P:establishment of epithelial cell apical/basal polarity; IMP:FlyBase.::GO:0090163; P:establishment of epithelial cell planar polarity; IMP:FlyBase.::GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.::GO:0048106; P:establishment of thoracic bristle planar orientation; TAS:FlyBase.::GO:0008585; P:female gonad development; IMP:FlyBase.::GO:0046847; P:filopodium assembly; IMP:FlyBase.::GO:0060914; P:heart formation; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030032; P:lamellipodium assembly; IMP:FlyBase.::GO:0003136; P:negative regulation of heart induction by canonical Wnt receptor signaling pathway; IMP:FlyBase.::GO:0016318; P:ommatidial rotation; NAS:FlyBase.::GO:0008104; P:protein localization; TAS:FlyBase.::GO:0007464; P:R3/R4 cell fate commitment; NAS:FlyBase.::GO:0032231; P:regulation of actin filament bundle assembly; IGI:FlyBase.::GO:0048076; P:regulation of compound eye pigmentation; IMP:FlyBase.::GO:0035159; P:regulation of tube length, open tracheal system; IMP:FlyBase.::GO:0031290; P:retinal ganglion cell axon guidance; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.::GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.::GO:0035019; P:somatic stem cell maintenance; IMP:FlyBase.::GO:0035309; P:wing and notum subfield formation; IMP:FlyBase.::GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IBA:RefGenome.
53P54792    670   DVL1L_HUMAN Putative Segment polarity protein...820.15     40.4     22     48GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0007507; P:heart development; NAS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
54Q8C0Q9    814   RPGF5_MOUSE Rap guanine nucleotide exchange f...540.31     39.3     37     54GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0030742; F:GTP-dependent protein binding; ISS:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
55Q8VCC8    918   RPGF3_MOUSE Rap guanine nucleotide exchange f...710.7     38.1     30     51GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:MGI.
GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
56Q8BH88    529   DEP1B_MOUSE DEP domain-containing protein 1B ...1040.95     37.7     27     42GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
57Q4R623    529   DEP1B_MACFA DEP domain-containing protein 1B ...822.6     36.2     26     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
58Q8WUY9    529   DEP1B_HUMAN DEP domain-containing protein 1B ...822.6     36.2     26     48GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
59P49802    495   RGS7_HUMAN Regulator of G-protein signaling 7...892.6     36.2     30     45GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
60P49803    477   RGS7_RAT Regulator of G-protein signaling 7 O...892.7     36.2     30     45GO:0005829; C:cytosol; IDA:RGD.::GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IBA:RefGenome.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
61O46470    469   RGS7_BOVIN Regulator of G-protein signaling 7...902.9     36.2     30     44GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
GO:0005096; F:GTPase activator activity; ISS:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
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