Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YJR110W
Length:
688
Number of sequences:
5887
Description:
YJR110W YMR1 SGDID:S000003871, Chr X from 633615-635681, Genome Release 64-1-1, Verified ORF, "Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P47147    688   YMR1_YEAST Phosphoinositide 3-phosphatase OS=...6880     1427     100     100GO:0005737; C:cytoplasm; IDA:SGD.
GO:0003729; F:mRNA binding; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IMP:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0046856; P:phosphatidylinositol dephosphorylation; IMP:UniProtKB.
2O13819    559   YMR1_SCHPO Phosphoinositide 3-phosphatase OS=...6491e-128     399     37     53GO:0005829; C:cytosol; IDA:PomBase.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:PomBase.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0048017; P:inositol lipid-mediated signaling; ISS:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; ISS:PomBase.
3A0JMK5    620   MTMR2_DANRE Myotubularin-related protein 2 OS...4854e-71     248     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
4Q13613    665   MTMR1_HUMAN Myotubularin-related protein 1 OS...4711e-66     237     32     49GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
5Q9Z2C4    669   MTMR1_MOUSE Myotubularin-related protein 1 OS...4711e-65     234     32     49GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
6Q5ZIV1    571   MTMR2_CHICK Myotubularin-related protein 2 OS...5847e-65     230     29     48
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
7Q8VE11    617   MTMR6_MOUSE Myotubularin-related protein 6 OS...793e-16     85.9     48     68GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
8Q96EF0    704   MTMR8_HUMAN Myotubularin-related protein 8 OS...812e-16     87     48     65GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
9Q13614    643   MTMR2_HUMAN Myotubularin-related protein 2 OS...5812e-62     225     28     47GO:0030424; C:axon; ISS:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL.::GO:0097060; C:synaptic membrane; ISS:BHF-UCL.::GO:0008021; C:synaptic vesicle; ISS:BHF-UCL.
GO:0004437; F:inositol or phosphatidylinositol phosphatase activity; TAS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; NAS:UniProtKB.
GO:0097062; P:dendritic spine maintenance; ISS:BHF-UCL.::GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:2000645; P:negative regulation of receptor catabolic process; ISS:BHF-UCL.::GO:0002091; P:negative regulation of receptor internalization; ISS:BHF-UCL.::GO:2000643; P:positive regulation of early endosome to late endosome transport; ISS:BHF-UCL.
10Q9Z2D1    643   MTMR2_MOUSE Myotubularin-related protein 2 OS...5812e-62     224     28     47GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005774; C:vacuolar membrane; IDA:MGI.
GO:0042803; F:protein homodimerization activity; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.::GO:0051262; P:protein tetramerization; IPI:MGI.
11Q5R6F6    660   MTMR7_PONAB Myotubularin-related protein 7 OS...966e-18     91.7     44     64GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
12Q9Y216    660   MTMR7_HUMAN Myotubularin-related protein 7 OS...965e-18     92     44     64
GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc.
13Q6TEL0    632   MTMR8_DANRE Myotubularin-related protein 8 OS...810.00000000000002     80.9     46     63GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
14Q5REB9    643   MTMR2_PONAB Myotubularin-related protein 2 OS...5819e-62     223     28     47GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
15Q9Z2C9    660   MTMR7_MOUSE Myotubularin-related protein 7 OS...962e-17     89.7     44     61GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.
16A6QLT2    643   MTMR2_BOVIN Myotubularin-related protein 2 OS...5814e-61     221     28     47GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
17Q5R9S3    603   MTM1_PONAB Myotubularin OS=Pongo abelii (Suma...4485e-61     220     32     49GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB.
18Q13496    603   MTM1_HUMAN Myotubularin OS=Homo sapiens (Huma...4488e-61     219     32     49GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB.
GO:0019215; F:intermediate filament binding; IDA:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; IDA:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.::GO:0045109; P:intermediate filament organization; IMP:UniProtKB.::GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; IDA:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; IDA:UniProtKB.
19Q9Y217    621   MTMR6_HUMAN Myotubularin-related protein 6 OS...940.000000000000001     84.3     44     63GO:0005737; C:cytoplasm; IDA:LIFEdb.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0015269; F:calcium-activated potassium channel activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; NAS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB.
20Q5F452    629   MTMR8_CHICK Myotubularin-related protein 8 OS...810.000000000000006     82     46     64GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
21Q5EB32    602   MTM1_XENTR Myotubularin OS=Xenopus tropicalis...5813e-58     212     27     45GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:EC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
22Q9Z2C5    603   MTM1_MOUSE Myotubularin OS=Mus musculus (Mous...4483e-58     212     32     49GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.::GO:0046716; P:muscle cell homeostasis; IMP:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB.
23Q52KU6    602   MTM1_XENLA Myotubularin OS=Xenopus laevis (Af...4655e-58     212     30     47GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:EC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
24Q7ZXF1    1078   MTMR4_XENLA Myotubularin-related protein 4 OS...4716e-58     216     33     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
25Q6AXQ4    602   MTM1_RAT Myotubularin OS=Rattus norvegicus (R...4482e-57     210     31     47GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB.
26Q91XS1    1190   MTMR4_MOUSE Myotubularin-related protein 4 OS...4704e-57     214     32     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
27Q13615    1198   MTMR3_HUMAN Myotubularin-related protein 3 OS...4754e-57     214     31     44GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
28Q8K296    1196   MTMR3_MOUSE Myotubularin-related protein 3 OS...4753e-56     212     30     44
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
29A6QLT4    603   MTM1_BOVIN Myotubularin OS=Bos taurus (Bovine...4485e-56     206     31     48GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB.
30Q5PQT2    1194   MTMR3_RAT Myotubularin-related protein 3 OS=R...4755e-56     211     30     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
31Q9NYA4    1195   MTMR4_HUMAN Myotubularin-related protein 4 OS...4853e-54     206     31     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc.
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