rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q62388 | 3066 | ATM_MOUSE Serine-protein kinase ATM OS=Mus mu... | 469 | 3e-46 | 189 | 31 | 48 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005819; C:spindle; IDA:MGI. | | | | | | | | | | GO:0016303; F:1-phosphatidylinositol-3-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0047485; F:protein N-terminus binding; ISS:UniProtKB. | | | | | | | | | | GO:0007420; P:brain development; IGI:MGI.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IMP:MGI.::GO:0006281; P:DNA repair; IDA:MGI.::GO:0007292; P:female gamete generation; IMP:MGI.::GO:0007507; P:heart development; IGI:MGI.::GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB.::GO:0042159; P:lipoprotein catabolic process; IGI:MGI.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0051402; P:neuron apoptotic process; IGI:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; IGI:MGI.::GO:0002331; P:pre-B cell allelic exclusion; IMP:UniProtKB.::GO:0001756; P:somitogenesis; IGI:MGI. | 32 | Q75DB8 | 2324 | ATR_ASHGO Serine/threonine-protein kinase MEC... | 383 | 4e-46 | 188 | 33 | 49 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 33 | Q6FX42 | 2379 | ATR_CANGA Serine/threonine-protein kinase MEC... | 90 | 0.006 | 45.8 | 28 | 52 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 34 | Q4WVM7 | 2796 | ATM_ASPFU Serine/threonine-protein kinase tel... | 388 | 1e-45 | 186 | 31 | 51 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 35 | Q5BHE2 | 2793 | ATM_EMENI Serine/threonine-protein kinase tel... | 385 | 6e-45 | 184 | 31 | 52 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 36 | Q9FKS4 | 2702 | ATR_ARATH Serine/threonine-protein kinase ATR... | 341 | 0.00000000001 | 74.3 | 24 | 41 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0009506; C:plasmodesma; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IGI:TAIR.::GO:0007126; P:meiosis; IGI:TAIR.::GO:0032504; P:multicellular organism reproduction; IGI:TAIR.::GO:0032204; P:regulation of telomere maintenance; IGI:TAIR.::GO:0010044; P:response to aluminum ion; IMP:TAIR.::GO:0010332; P:response to gamma radiation; IMP:TAIR.::GO:0043247; P:telomere maintenance in response to DNA damage; TAS:TAIR.::GO:0007004; P:telomere maintenance via telomerase; IMP:TAIR. | 37 | Q4IB89 | 2813 | ATM_GIBZE Serine/threonine-protein kinase TEL... | 384 | 9e-45 | 184 | 33 | 51 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 38 | Q6CP76 | 2761 | ATM_KLULA Serine/threonine-protein kinase TEL... | 370 | 1e-44 | 183 | 33 | 52 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 39 | Q751J3 | 2768 | ATM_ASHGO Serine/threonine-protein kinase TEL... | 386 | 2e-44 | 182 | 31 | 49 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 40 | Q2U639 | 2925 | ATM_ASPOR Serine/threonine-protein kinase tel... | 409 | 5e-44 | 181 | 32 | 50 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 41 | Q6CT34 | 2287 | ATR_KLULA Serine/threonine-protein kinase MEC... | 72 | 0.19 | 40.8 | 25 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 42 | Q7RZT9 | 2939 | ATM_NEUCR Serine/threonine-protein kinase tel... | 394 | 2e-43 | 179 | 32 | 48 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 43 | P38110 | 2787 | ATM_YEAST Serine/threonine-protein kinase TEL... | 368 | 5e-43 | 178 | 33 | 48 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IC:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0042162; F:telomeric DNA binding; IDA:SGD. | | | | | | | | | | GO:0006975; P:DNA damage induced protein phosphorylation; IMP:SGD.::GO:0006302; P:double-strand break repair; IMP:SGD.::GO:0016572; P:histone phosphorylation; IMP:SGD.::GO:0000723; P:telomere maintenance; IMP:SGD. | 44 | P38111 | 2368 | ATR_YEAST Serine/threonine-protein kinase MEC... | 82 | 2.2 | 37.4 | 30 | 49 | GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IC:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000077; P:DNA damage checkpoint; TAS:SGD.::GO:0006975; P:DNA damage induced protein phosphorylation; IMP:SGD.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IMP:SGD.::GO:0016572; P:histone phosphorylation; IMP:SGD.::GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.::GO:0000722; P:telomere maintenance via recombination; IGI:SGD. | 45 | O74630 | 2812 | ATM_SCHPO Serine/threonine-protein kinase tel... | 387 | 1e-41 | 173 | 29 | 51 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000077; P:DNA damage checkpoint; NAS:PomBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0016572; P:histone phosphorylation; IGI:PomBase.::GO:0000723; P:telomere maintenance; IMP:PomBase. | 46 | Q6FRZ9 | 2763 | ATM_CANGA Serine/threonine-protein kinase TEL... | 382 | 1e-41 | 173 | 31 | 49 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 47 | A2YH41 | 2710 | ATR_ORYSI Serine/threonine-protein kinase ATR... | 674 | 0.000000000000001 | 88.2 | 22 | 38 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 48 | Q5Z987 | 2710 | ATR_ORYSJ Serine/threonine-protein kinase ATR... | 674 | 0.000000000000001 | 88.2 | 22 | 38 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 49 | Q6CAD2 | 2282 | ATM_YARLI Serine/threonine-protein kinase TEL... | 142 | 5.7 | 36.2 | 20 | 50 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 50 | Q9DEI1 | 4146 | PRKDC_XENLA DNA-dependent protein kinase cata... | 682 | 3e-37 | 159 | 24 | 44 | GO:0070419; C:nonhomologous end joining complex; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro. | | | | | | | | | | GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. | 51 | Q54UC0 | 4299 | PRKDC_DICDI DNA-dependent protein kinase cata... | 451 | 9e-37 | 157 | 27 | 46 | GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; ISS:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro. | | | | | | | | | | GO:0006975; P:DNA damage induced protein phosphorylation; IMP:dictyBase.::GO:0006310; P:DNA recombination; ISS:dictyBase.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. | 52 | Q8QGX4 | 4134 | PRKDC_CHICK DNA-dependent protein kinase cata... | 525 | 3e-36 | 155 | 25 | 48 | GO:0070419; C:nonhomologous end joining complex; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro. | | | | | | | | | | GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:Reactome. | 53 | Q8WN22 | 4144 | PRKDC_CANFA DNA-dependent protein kinase cata... | 351 | 6e-36 | 155 | 31 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. | 54 | P78527 | 4128 | PRKDC_HUMAN DNA-dependent protein kinase cata... | 532 | 2e-35 | 153 | 27 | 48 | GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IDA:MGI.::GO:0005667; C:transcription factor complex; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004677; F:DNA-dependent protein kinase activity; IDA:MGI.::GO:0008134; F:transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.::GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:Reactome.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. | 55 | Q8SSE7 | 1935 | ATR_ENCCU Probable serine/threonine-protein k... | 388 | 1e-32 | 144 | 27 | 43 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 56 | P0CP61 | 2968 | ATM_CRYNB Serine/threonine-protein kinase TEL... | 504 | 1e-32 | 143 | 25 | 41 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008565; F:protein transporter activity; IEA:InterPro. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006886; P:intracellular protein transport; IEA:InterPro. | 57 | P97313 | 4128 | PRKDC_MOUSE DNA-dependent protein kinase cata... | 352 | 2e-32 | 143 | 30 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0019899; F:enzyme binding; IPI:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:MGI.::GO:0002326; P:B cell lineage commitment; IMP:MGI.::GO:0007420; P:brain development; IGI:MGI.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.::GO:0035234; P:germ cell programmed cell death; IMP:MGI.::GO:0007507; P:heart development; IGI:MGI.::GO:0033152; P:immunoglobulin V(D)J recombination; IMP:MGI.::GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.::GO:0002328; P:pro-B cell differentiation; IMP:MGI.::GO:0031648; P:protein destabilization; IDA:MGI.::GO:0010332; P:response to gamma radiation; IMP:MGI.::GO:0001756; P:somitogenesis; IGI:MGI.::GO:0033077; P:T cell differentiation in thymus; IMP:MGI.::GO:0002360; P:T cell lineage commitment; IMP:MGI.::GO:0033153; P:T cell receptor V(D)J recombination; IMP:MGI.::GO:0000723; P:telomere maintenance; IMP:MGI. | 58 | P0CP60 | 2967 | ATM_CRYNJ Serine/threonine-protein kinase TEL... | 504 | 2e-32 | 143 | 25 | 41 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008565; F:protein transporter activity; IEA:InterPro. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006886; P:intracellular protein transport; IEA:InterPro. | 59 | Q553E9 | 2344 | SMG1_DICDI Probable serine/threonine-protein ... | 56 | 1.1 | 38.5 | 30 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. | 60 | Q9N3Q4 | 649 | ATM_CAEEL Serine/threonine-protein kinase ATM... | 404 | 4e-25 | 117 | 24 | 43 | GO:0000785; C:chromatin; IDA:WormBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 61 | Q22258 | 2531 | ATR_CAEEL Serine/threonine-protein kinase ATR... | 409 | 5e-23 | 112 | 25 | 42 | GO:0000794; C:condensed nuclear chromosome; TAS:WormBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0045132; P:meiotic chromosome segregation; IMP:WormBase. |