rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q8H0T4 | 3658 | UPL2_ARATH E3 ubiquitin-protein ligase UPL2 O... | 379 | 9e-46 | 183 | 30 | 52 | GO:0005829; C:cytosol; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.::GO:0005488; F:binding; IEA:InterPro. | | | | | | | | | | GO:0006464; P:protein modification process; IEA:InterPro. | 32 | Q2TAS2 | 751 | SMUF2_XENLA E3 ubiquitin-protein ligase SMURF... | 377 | 1e-45 | 179 | 31 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. | | | | | | | | | | | 33 | Q756G2 | 3258 | TOM1_ASHGO Probable E3 ubiquitin-protein liga... | 378 | 1e-44 | 179 | 32 | 53 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:RefGenome. | | | | | | | | | | GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. | 34 | A2A5Z6 | 748 | SMUF2_MOUSE E3 ubiquitin-protein ligase SMURF... | 376 | 2e-44 | 175 | 32 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 35 | P39940 | 809 | RSP5_YEAST E3 ubiquitin-protein ligase RSP5 O... | 375 | 5e-44 | 175 | 31 | 51 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0010008; C:endosome membrane; IDA:SGD.::GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:SGD.::GO:0005794; C:Golgi apparatus; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD.::GO:0000151; C:ubiquitin ligase complex; IDA:MGI. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IDA:SGD.::GO:0043130; F:ubiquitin binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI. | | | | | | | | | | GO:0034644; P:cellular response to UV; IMP:SGD.::GO:0006333; P:chromatin assembly or disassembly; IMP:SGD.::GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IMP:SGD.::GO:0007005; P:mitochondrion organization; IMP:SGD.::GO:0045723; P:positive regulation of fatty acid biosynthetic process; IMP:SGD.::GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:SGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IPI:SGD.::GO:0006513; P:protein monoubiquitination; IMP:SGD.::GO:0000209; P:protein polyubiquitination; IMP:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0032956; P:regulation of actin cytoskeleton organization; IGI:SGD.::GO:0010794; P:regulation of dolichol biosynthetic process; IMP:SGD.::GO:0032443; P:regulation of ergosterol biosynthetic process; IMP:SGD.::GO:0010793; P:regulation of mRNA export from nucleus; IMP:SGD.::GO:0010796; P:regulation of multivesicular body size; IMP:SGD.::GO:0006808; P:regulation of nitrogen utilization; IGI:SGD.::GO:0019220; P:regulation of phosphate metabolic process; IGI:SGD.::GO:0032880; P:regulation of protein localization; IMP:SGD.::GO:2000203; P:regulation of ribosomal large subunit export from nucleus; IMP:SGD.::GO:2000232; P:regulation of rRNA processing; IMP:SGD.::GO:2000238; P:regulation of tRNA export from nucleus; IMP:SGD.::GO:2000235; P:regulation of tRNA processing; IMP:SGD.::GO:0010795; P:regulation of ubiquinone biosynthetic process; IMP:SGD.::GO:0042493; P:response to drug; IMP:SGD.::GO:0034517; P:ribophagy; IGI:SGD.::GO:0070086; P:ubiquitin-dependent endocytosis; IMP:SGD.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:SGD. | 36 | Q03280 | 3268 | TOM1_YEAST E3 ubiquitin-protein ligase TOM1 O... | 381 | 1e-43 | 176 | 31 | 54 | GO:0005730; C:nucleolus; IDA:SGD. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD. | | | | | | | | | | GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0007067; P:mitosis; IMP:SGD.::GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0006913; P:nucleocytoplasmic transport; IMP:SGD.::GO:0006997; P:nucleus organization; IMP:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0008361; P:regulation of cell size; IMP:SGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 37 | Q8IVU3 | 1022 | HERC6_HUMAN Probable E3 ubiquitin-protein lig... | 422 | 1e-43 | 175 | 29 | 49 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 38 | Q9PUN2 | 731 | SMUF1_XENLA E3 ubiquitin-protein ligase SMURF... | 380 | 1e-43 | 173 | 31 | 51 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IDA:UniProtKB.::GO:0007398; P:ectoderm development; TAS:UniProtKB.::GO:0030514; P:negative regulation of BMP signaling pathway; TAS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 39 | Q9HAU4 | 748 | SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF... | 376 | 2e-43 | 173 | 31 | 50 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; NAS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046332; F:SMAD binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; TAS:Reactome.::GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; NAS:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.::GO:0030579; P:ubiquitin-dependent SMAD protein catabolic process; IDA:BHF-UCL. | 40 | Q9UTG2 | 671 | PUB2_SCHPO E3 ubiquitin-protein ligase pub2 O... | 398 | 2e-42 | 169 | 30 | 49 | GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IGI:PomBase. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. | 41 | Q9VVI3 | 1007 | NEDD4_DROME E3 ubiquitin-protein ligase Nedd-... | 397 | 2e-41 | 168 | 31 | 48 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IDA:FlyBase.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB. | | | | | | | | | | GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.::GO:0045746; P:negative regulation of Notch signaling pathway; IMP:UniProtKB.::GO:0007528; P:neuromuscular junction development; IMP:FlyBase.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0002092; P:positive regulation of receptor internalization; IMP:FlyBase.::GO:0051965; P:positive regulation of synapse assembly; IMP:FlyBase.::GO:0031623; P:receptor internalization; IMP:UniProtKB. | 42 | Q9V853 | 1061 | SMUF1_DROME E3 ubiquitin-protein ligase Smurf... | 379 | 2e-41 | 168 | 30 | 50 | GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0008101; P:decapentaplegic signaling pathway; IMP:UniProtKB.::GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:UniProtKB.::GO:0048619; P:embryonic hindgut morphogenesis; IMP:UniProtKB.::GO:0010629; P:negative regulation of gene expression; IDA:FlyBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0040008; P:regulation of growth; IMP:FlyBase. | 43 | Q96J02 | 903 | ITCH_HUMAN E3 ubiquitin-protein ligase Itchy ... | 379 | 3e-41 | 167 | 30 | 51 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0045236; F:CXCR chemokine receptor binding; IPI:UniProtKB.::GO:0043021; F:ribonucleoprotein complex binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; NAS:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0050687; P:negative regulation of defense response to virus; IMP:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0035519; P:protein K29-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0090085; P:regulation of protein deubiquitination; ISS:BHF-UCL.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB. | 44 | Q8C863 | 864 | ITCH_MOUSE E3 ubiquitin-protein ligase Itchy ... | 379 | 4e-41 | 166 | 30 | 51 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0050687; P:negative regulation of defense response to virus; IMP:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; IMP:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0002669; P:positive regulation of T cell anergy; IMP:MGI.::GO:0035519; P:protein K29-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI.::GO:0090085; P:regulation of protein deubiquitination; IMP:BHF-UCL.::GO:0009615; P:response to virus; IEA:UniProtKB-KW. | 45 | Q9DBH0 | 870 | WWP2_MOUSE NEDD4-like E3 ubiquitin-protein li... | 381 | 8e-39 | 159 | 28 | 51 | GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:BHF-UCL. | | | | | | | | | | GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 46 | Q8CFI0 | 1004 | NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4... | 392 | 1e-38 | 159 | 30 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 47 | Q5RBF2 | 959 | NED4L_PONAB E3 ubiquitin-protein ligase NEDD4... | 392 | 1e-38 | 159 | 30 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. | | | | | | | | | | | 48 | Q96PU5 | 975 | NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4... | 392 | 1e-38 | 159 | 30 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB. | | | | | | | | | | GO:0006883; P:cellular sodium ion homeostasis; NAS:UniProtKB.::GO:0007588; P:excretion; NAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0045807; P:positive regulation of endocytosis; NAS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0042176; P:regulation of protein catabolic process; NAS:UniProtKB.::GO:0010038; P:response to metal ion; IDA:UniProtKB.::GO:0006814; P:sodium ion transport; NAS:UniProtKB.::GO:0030104; P:water homeostasis; NAS:UniProtKB. | 49 | O00308 | 870 | WWP2_HUMAN NEDD4-like E3 ubiquitin-protein li... | 382 | 2e-38 | 158 | 29 | 50 | GO:0005737; C:cytoplasm; ISS:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; TAS:ProtInc. | | | | | | | | | | GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0051224; P:negative regulation of protein transport; IMP:UniProtKB.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB. | 50 | P46934 | 1319 | NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4... | 392 | 7e-38 | 157 | 30 | 48 | GO:0016327; C:apicolateral plasma membrane; TAS:BHF-UCL.::GO:0005938; C:cell cortex; IDA:BHF-UCL.::GO:0000785; C:chromatin; IDA:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0000151; C:ubiquitin ligase complex; ISS:BHF-UCL. | | | | | | | | | | GO:0031698; F:beta-2 adrenergic receptor binding; IDA:UniProtKB.::GO:0050815; F:phosphoserine binding; ISS:BHF-UCL.::GO:0050816; F:phosphothreonine binding; ISS:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0070063; F:RNA polymerase binding; IPI:BHF-UCL.::GO:0019871; F:sodium channel inhibitor activity; IDA:BHF-UCL.::GO:0043130; F:ubiquitin binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0044111; P:development involved in symbiotic interaction; IMP:UniProtKB.::GO:0042921; P:glucocorticoid receptor signaling pathway; IDA:BHF-UCL.::GO:0010766; P:negative regulation of sodium ion transport; IDA:UniProtKB.::GO:0010768; P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IMP:BHF-UCL.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0031175; P:neuron projection development; IEP:BHF-UCL.::GO:0046824; P:positive regulation of nucleocytoplasmic transport; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006622; P:protein targeting to lysosome; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0032801; P:receptor catabolic process; IDA:UniProtKB.::GO:0031623; P:receptor internalization; IDA:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.::GO:0051592; P:response to calcium ion; TAS:BHF-UCL.::GO:0019089; P:transmission of virus; IMP:BHF-UCL.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:BHF-UCL. | 51 | Q62940 | 887 | NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 O... | 392 | 3e-37 | 154 | 30 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005902; C:microvillus; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006955; P:immune response; IEP:RGD.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB. | 52 | Q9H0M0 | 922 | WWP1_HUMAN NEDD4-like E3 ubiquitin-protein li... | 388 | 4e-37 | 154 | 29 | 50 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB. | | | | | | | | | | GO:0007417; P:central nervous system development; NAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007165; P:signal transduction; NAS:UniProtKB.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB. | 53 | P46935 | 887 | NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4... | 392 | 4e-37 | 154 | 30 | 47 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IPI:MGI. | | | | | | | | | | GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI. | | | | | | | | | | GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB. | 54 | Q8BZZ3 | 918 | WWP1_MOUSE NEDD4-like E3 ubiquitin-protein li... | 386 | 6e-37 | 153 | 29 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030324; P:lung development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0030217; P:T cell differentiation; TAS:UniProtKB. | 55 | Q9P2P5 | 1572 | HECW2_HUMAN E3 ubiquitin-protein ligase HECW2... | 378 | 1e-36 | 154 | 30 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 56 | Q6I6G8 | 1578 | HECW2_MOUSE E3 ubiquitin-protein ligase HECW2... | 378 | 1e-36 | 154 | 30 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 57 | Q9Y0H4 | 949 | SUDX_DROME E3 ubiquitin-protein ligase Su(dx)... | 380 | 1e-36 | 152 | 29 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IMP:UniProtKB.::GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IGI:FlyBase.::GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:UniProtKB.::GO:0019915; P:lipid storage; IDA:FlyBase.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:UniProtKB.::GO:0007219; P:Notch signaling pathway; IGI:FlyBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0035209; P:pupal development; IMP:UniProtKB.::GO:0031623; P:receptor internalization; IMP:UniProtKB.::GO:0032880; P:regulation of protein localization; IMP:FlyBase.::GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:UniProtKB. | 58 | Q76N89 | 1606 | HECW1_HUMAN E3 ubiquitin-protein ligase HECW1... | 380 | 2e-36 | 153 | 30 | 47 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 59 | Q7TMY8 | 4377 | HUWE1_MOUSE E3 ubiquitin-protein ligase HUWE1... | 453 | 2e-36 | 153 | 29 | 49 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006284; P:base-excision repair; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016574; P:histone ubiquitination; ISS:UniProtKB.::GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 60 | Q7Z6Z7 | 4374 | HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1... | 453 | 2e-36 | 153 | 29 | 49 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006284; P:base-excision repair; IMP:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016574; P:histone ubiquitination; IDA:UniProtKB.::GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 61 | Q8K4P8 | 1604 | HECW1_MOUSE E3 ubiquitin-protein ligase HECW1... | 380 | 5e-36 | 151 | 30 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |