Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YJL141C
Length:
807
Number of sequences:
5887
Description:
YJL141C YAK1 SGDID:S000003677, Chr X from 150390-147967, Genome Release 64-1-1, reverse complement, Verified ORF, "Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
991O54781    681   SRPK2_MOUSE SRSF protein kinase 2 OS=Mus musc...1050.00000004     60.5     34     51GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0071889; F:14-3-3 protein binding; IDA:BHF-UCL.::GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; IDA:BHF-UCL.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0045071; P:negative regulation of viral genome replication; ISS:BHF-UCL.::GO:0035063; P:nuclear speck organization; IDA:BHF-UCL.::GO:0045787; P:positive regulation of cell cycle; IDA:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.::GO:0010628; P:positive regulation of gene expression; IDA:BHF-UCL.::GO:0043525; P:positive regulation of neuron apoptotic process; IDA:BHF-UCL.::GO:0045070; P:positive regulation of viral genome replication; ISS:BHF-UCL.::GO:0000245; P:spliceosomal complex assembly; IDA:UniProtKB.
992P78362    688   SRPK2_HUMAN SRSF protein kinase 2 OS=Homo sap...1050.00000005     60.1     34     51GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0071889; F:14-3-3 protein binding; ISS:BHF-UCL.::GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; ISS:BHF-UCL.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IC:BHF-UCL.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0045071; P:negative regulation of viral genome replication; IDA:BHF-UCL.::GO:0035063; P:nuclear speck organization; ISS:BHF-UCL.::GO:0045787; P:positive regulation of cell cycle; ISS:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL.::GO:0010628; P:positive regulation of gene expression; ISS:BHF-UCL.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:BHF-UCL.::GO:0045070; P:positive regulation of viral genome replication; IDA:BHF-UCL.::GO:0048024; P:regulation of nuclear mRNA splicing, via spliceosome; TAS:UniProtKB.::GO:0000245; P:spliceosomal complex assembly; IDA:UniProtKB.
993Q03563    1003   SPK1_CAEEL Serine/threonine-protein kinase sp...2910.0000003     58.2     24     40
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0000910; P:cytokinesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IGI:UniProtKB.::GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.
994Q9Z0G2    565   SRPK3_MOUSE SRSF protein kinase 3 OS=Mus musc...1170.0000005     57     32     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
995Q9UPE1    567   SRPK3_HUMAN SRSF protein kinase 3 OS=Homo sap...1170.0000005     56.6     32     53
GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
996B8Y466    566   SRPK3_PIG SRSF protein kinase 3 OS=Sus scrofa...1170.0000008     56.2     32     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0060537; P:muscle tissue development; ISS:UniProtKB.
997Q61IS6    1132   SPK1_CAEBR Serine/threonine-protein kinase sp...1020.0002     48.9     29     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
998P18654    740   KS6A3_MOUSE Ribosomal protein S6 kinase alpha...2050.0007     47     25     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0032496; P:response to lipopolysaccharide; IMP:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0002224; P:toll-like receptor signaling pathway; IMP:UniProtKB.
999P51812    740   KS6A3_HUMAN Ribosomal protein S6 kinase alpha...2050.0008     46.6     25     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045597; P:positive regulation of cell differentiation; TAS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043620; P:regulation of DNA-dependent transcription in response to stress; TAS:UniProtKB.::GO:0043555; P:regulation of translation in response to stress; TAS:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.::GO:0001501; P:skeletal system development; TAS:ProtInc.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
1000Q5VST9    7968   OBSCN_HUMAN Obscurin OS=Homo sapiens (Human)....2070.008     43.9     23     46GO:0005829; C:cytosol; TAS:Reactome.::GO:0031430; C:M band; ISS:BHF-UCL.::GO:0030018; C:Z disc; ISS:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0008307; F:structural constituent of muscle; NAS:BHF-UCL.::GO:0031432; F:titin binding; IPI:BHF-UCL.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
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