UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YIR006C

Length:

1480

Number of sequences:

5887

Description:

YIR006C PAN1 SGDID:S000001445, Chr IX from 369908-365466, Genome Release 64-1-1, reverse complement, Verified ORF, "Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	B0XR88	404	END3_ASPFC Actin cytoskeleton-regulatory comp...	63	0.011	43.5	35	54	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
62	A1D2B8	404	END3_NEOFI Actin cytoskeleton-regulatory comp...	63	0.011	43.5	35	54	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
63	Q641Z6	534	EHD1_RAT EH domain-containing protein 1 OS=Ra...	59	0.00005	51.6	44	58	GO:0031901; C:early endosome membrane; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
64	Q9WVK4	534	EHD1_MOUSE EH domain-containing protein 1 OS=...	59	0.00005	51.6	44	58	GO:0031901; C:early endosome membrane; ISS:UniProtKB.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0005811; C:lipid particle; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0031095; C:platelet dense tubular network membrane; IDA:BHF-UCL.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.
									GO:0042632; P:cholesterol homeostasis; IMP:BHF-UCL.::GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0006897; P:endocytosis; IDA:MGI.::GO:0006886; P:intracellular protein transport; ISS:UniProtKB.::GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL.::GO:0010886; P:positive regulation of cholesterol storage; IMP:BHF-UCL.
65	Q5RBP4	534	EHD1_PONAB EH domain-containing protein 1 OS=...	93	0.00008	50.8	34	52	GO:0031901; C:early endosome membrane; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.
									GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
66	Q9H4M9	534	EHD1_HUMAN EH domain-containing protein 1 OS=...	93	0.00008	50.8	34	52	GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0005811; C:lipid particle; ISS:BHF-UCL.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0031095; C:platelet dense tubular network membrane; ISS:BHF-UCL.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL.::GO:0032456; P:endocytic recycling; IMP:UniProtKB.::GO:0006886; P:intracellular protein transport; IMP:UniProtKB.::GO:0034383; P:low-density lipoprotein particle clearance; ISS:BHF-UCL.::GO:0010886; P:positive regulation of cholesterol storage; ISS:BHF-UCL.::GO:0051260; P:protein homooligomerization; IPI:UniProtKB.
67	Q7S9V9	396	END3_NEUCR Actin cytoskeleton-regulatory comp...	77	0.00006	50.8	39	53	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
68	Q5E9R3	534	EHD1_BOVIN EH domain-containing protein 1 OS=...	189	0.00005	51.6	25	42	GO:0031901; C:early endosome membrane; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.
									GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
69	A6SIJ6	404	END3_BOTFB Actin cytoskeleton-regulatory comp...	70	0.000001	56.6	40	56	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
70	A6RFP4	405	END3_AJECN Actin cytoskeleton-regulatory comp...	71	0.003	45.4	37	55	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
71	A7E7N7	400	END3_SCLS1 Actin cytoskeleton-regulatory comp...	70	0.000001	56.2	40	56	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
72	A3LPY4	628	IRS4_PICST Increased rDNA silencing protein 4...	58	0.000006	54.7	43	55
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
73	Q80XA6	521	REPS2_MOUSE RalBP1-associated Eps domain-cont...	70	0.0008	47.8	33	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.
74	Q1DUU2	404	END3_COCIM Actin cytoskeleton-regulatory comp...	63	0.003	45.4	38	56	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
75	Q8NFH8	660	REPS2_HUMAN RalBP1-associated Eps domain-cont...	70	0.0002	49.3	34	51	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:ProtInc.::GO:0006461; P:protein complex assembly; TAS:ProtInc.
76	Q0D0N9	404	END3_ASPTN Actin cytoskeleton-regulatory comp...	78	0.022	42.7	32	55	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
77	Q9H223	541	EHD4_HUMAN EH domain-containing protein 4 OS=...	96	0.00004	51.6	31	55	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.::GO:0005634; C:nucleus; TAS:ProtInc.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0032456; P:endocytic recycling; IGI:UniProtKB.::GO:0051260; P:protein homooligomerization; IPI:UniProtKB.
78	A7TKW4	1202	SLA1_VANPO Actin cytoskeleton-regulatory comp...	260	0.00008	51.2	30	39	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0030674; F:protein binding, bridging; IEA:InterPro.::GO:0043130; F:ubiquitin binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
79	A2RA84	504	IRS4_ASPNC Increased rDNA silencing protein 4...	49	0.026	42.7	41	53
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
80	Q9EQP2	541	EHD4_MOUSE EH domain-containing protein 4 OS=...	96	0.00001	53.5	32	55	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
81	Q59SR6	638	IRS4_CANAL Increased rDNA silencing protein 4...	69	0.000003	55.8	42	55
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0044406; P:adhesion to host; IMP:CGD.::GO:0031505; P:fungal-type cell wall organization; IMP:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.::GO:0009405; P:pathogenesis; IMP:CGD.
82	Q6BY77	393	END3_DEBHA Actin cytoskeleton-regulatory comp...	156	1.2	37	26	49	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
83	A4QST9	680	IRS4_MAGO7 Increased rDNA silencing protein 4...	111	0.0002	49.3	26	45
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
84	Q5BEK7	404	END3_EMENI Actin cytoskeleton-regulatory comp...	63	0.15	40	33	52	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
85	O13858	636	YEX7_SCHPO Uncharacterized protein C1A6.07 OS...	100	0.000007	54.3	41	53	GO:0005576; C:extracellular region; IEA:UniProtKB-KW.::GO:0009277; C:fungal-type cell wall; IDA:PomBase.
									GO:0033554; P:cellular response to stress; IEP:PomBase.
86	Q7SB65	856	IRS4_NEUCR Increased rDNA silencing protein 4...	69	0.0001	50.4	38	51
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
87	Q9Z0R6	1659	ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo...	57	0.008	44.7	39	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
88	A5DXI9	362	END3_LODEL Actin cytoskeleton-regulatory comp...	66	0.0001	50.1	38	58	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
89	Q9NZM3	1697	ITSN2_HUMAN Intersectin-2 OS=Homo sapiens (Hu...	57	0.004	45.8	39	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
90	Q9NZN4	543	EHD2_HUMAN EH domain-containing protein 2 OS=...	51	0.00003	52	43	61	GO:0005634; C:nucleus; TAS:ProtInc.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; TAS:ProtInc.
									GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0032456; P:endocytic recycling; IGI:UniProtKB.
91	Q8BH64	543	EHD2_MOUSE EH domain-containing protein 2 OS=...	51	0.00002	52.4	43	61	GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IDA:MGI.
									GO:0030866; P:cortical actin cytoskeleton organization; IDA:MGI.::GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0006897; P:endocytosis; IDA:MGI.

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