Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YIL094C
Length:
371
Number of sequences:
5887
Description:
YIL094C LYS12 SGDID:S000001356, Chr IX from 187632-186517, Genome Release 64-1-1, reverse complement, Verified ORF, "Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P40495    371   LYS12_YEAST Homoisocitrate dehydrogenase, mit...3710     757     100     100GO:0005739; C:mitochondrion; IDA:SGD.
GO:0047046; F:homoisocitrate dehydrogenase activity; IDA:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
2O14104    362   LYS12_SCHPO Probable homoisocitrate dehydroge...3612e-158     456     61     77GO:0005739; C:mitochondrion; ISS:PomBase.
GO:0047046; F:homoisocitrate dehydrogenase activity; ISS:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006091; P:generation of precursor metabolites and energy; NAS:PomBase.::GO:0009085; P:lysine biosynthetic process; IMP:PomBase.
3Q58130    333   LEU3_METJA 3-isopropylmalate/3-methylmalate d...3483e-82     260     46     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.::GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
4O29627    326   LEU3_ARCFU 3-isopropylmalate dehydrogenase OS...3481e-80     256     45     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
5O27441    329   LEU3_METTH 3-isopropylmalate dehydrogenase OS...3525e-77     247     43     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
6Q58991    347   AKSF_METJA Homoisocitrate dehydrogenase OS=JC...3615e-76     245     40     58
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:InterPro.::GO:0047046; F:homoisocitrate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
7P50455    337   LEU3_SULTO 3-isopropylmalate dehydrogenase OS...3571e-68     226     37     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
8Q9UXB2    336   LEU3_SULSO 3-isopropylmalate dehydrogenase OS...3542e-67     222     38     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
9Q945K7    374   IDH5_ARATH Isocitrate dehydrogenase [NAD] cat...3514e-65     217     37     56GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0005524; F:ATP binding; IDA:TAIR.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:TAIR.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IDA:TAIR.
GO:0006102; P:isocitrate metabolic process; IMP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
10P76251    361   DMLA_ECOLI D-malate dehydrogenase [decarboxyl...3682e-62     209     38     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006108; P:malate metabolic process; IDA:UniProtKB.
11O66607    364   LEU3_AQUAE 3-isopropylmalate dehydrogenase OS...3681e-61     207     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
12Q93714    358   IDH3A_CAEEL Probable isocitrate dehydrogenase...3483e-61     207     36     57GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0016246; P:RNA interference; IMP:WormBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
13P50213    366   IDH3A_HUMAN Isocitrate dehydrogenase [NAD] su...3524e-61     206     38     56GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
14Q55BI2    354   IDHA_DICDI Isocitrate dehydrogenase [NAD] reg...3751e-60     205     37     53GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
15P41563    366   IDH3A_BOVIN Isocitrate dehydrogenase [NAD] su...3521e-60     205     37     56GO:0005739; C:mitochondrion; ISS:AgBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
16Q5R678    366   IDH3A_PONAB Isocitrate dehydrogenase [NAD] su...3521e-60     205     37     56GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
17Q51945    365   TTUC_PSEPU Tartrate dehydrogenase/decarboxyla...3732e-60     205     38     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
18Q9D6R2    366   IDH3A_MOUSE Isocitrate dehydrogenase [NAD] su...3522e-60     204     37     56GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
19Q28480    347   IDH3A_MACFA Isocitrate dehydrogenase [NAD] su...3524e-60     203     37     56GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
20Q8LG77    374   IDH6_ARATH Isocitrate dehydrogenase [NAD] cat...3482e-59     202     36     55GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
21Q99NA5    366   IDH3A_RAT Isocitrate dehydrogenase [NAD] subu...3522e-58     199     36     56GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IC:RGD.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IDA:RGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.::GO:0006102; P:isocitrate metabolic process; IDA:RGD.::GO:0006734; P:NADH metabolic process; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IDA:RGD.
22Q9VWH4    377   IDH3A_DROME Probable isocitrate dehydrogenase...3644e-58     199     35     55GO:0005811; C:lipid particle; IDA:FlyBase.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; ISS:UniProtKB.
23Q8RDK0    355   LEU3_THETN 3-isopropylmalate dehydrogenase OS...3731e-57     197     39     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
24P24098    344   LEU3_THEAQ 3-isopropylmalate dehydrogenase OS...3653e-57     196     38     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
25P42958    354   TTUC_BACSU Probable tartrate dehydrogenase/de...3713e-57     196     34     52
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
26P70792    358   TTUC4_AGRVI Probable tartrate dehydrogenase/d...3651e-56     194     39     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
27P70787    364   TTUC2_AGRVI Probable tartrate dehydrogenase/d...3652e-56     194     39     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
28O29610    412   IDH_ARCFU Isocitrate dehydrogenase [NADP] OS=...3833e-56     195     34     53
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
29Q02143    345   LEU3_LACLA 3-isopropylmalate dehydrogenase OS...3545e-56     192     38     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
30Q9USP8    378   IDH2_SCHPO Isocitrate dehydrogenase [NAD] sub...3752e-55     192     34     55GO:0005759; C:mitochondrial matrix; ISS:PomBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006537; P:glutamate biosynthetic process; IMP:PomBase.::GO:0006102; P:isocitrate metabolic process; IMP:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IMP:PomBase.
31O13696    356   IDH1_SCHPO Isocitrate dehydrogenase [NAD] sub...3741e-54     189     36     53GO:0005759; C:mitochondrial matrix; ISS:PomBase.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006537; P:glutamate biosynthetic process; IMP:PomBase.::GO:0006102; P:isocitrate metabolic process; IMP:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IMP:PomBase.
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