Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YIL094C
Length:
371
Number of sequences:
5887
Description:
YIL094C LYS12 SGDID:S000001356, Chr IX from 187632-186517, Genome Release 64-1-1, reverse complement, Verified ORF, "Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
361B0RIP4    355   LEU3_CLAMS 3-isopropylmalate dehydrogenase OS...3233e-32     129     32     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
362Q8NKB8    362   LEU3_BLAAD 3-isopropylmalate dehydrogenase OS...3695e-32     128     33     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
363P87186    373   LEU3_CANAX 3-isopropylmalate dehydrogenase OS...3701e-31     127     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
364O85071    363   LEU3_BUCDN 3-isopropylmalate dehydrogenase OS...3792e-31     126     29     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
365C1B2M3    336   LEU3_RHOOB 3-isopropylmalate dehydrogenase OS...3302e-31     125     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
366Q0S2H1    336   LEU3_RHOSR 3-isopropylmalate dehydrogenase OS...3303e-31     125     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
367Q01987    365   LEU3_CANBO 3-isopropylmalate dehydrogenase OS...3662e-30     123     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
368Q9ZN36    425   IDH_HELPJ Isocitrate dehydrogenase [NADP] OS=...3748e-30     122     27     47
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
369Q9EVI4    363   LEU3_BUCUS 3-isopropylmalate dehydrogenase OS...3719e-30     121     28     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
370P56063    425   IDH_HELPY Isocitrate dehydrogenase [NADP] OS=...3782e-29     121     27     47
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
371C0ZXM4    337   LEU3_RHOE4 3-isopropylmalate dehydrogenase OS...3474e-29     119     33     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
372P50214    473   IDH_NOSS1 Isocitrate dehydrogenase [NADP] OS=...4171e-27     116     27     42
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
373P80046    475   IDH_SYNY3 Isocitrate dehydrogenase [NADP] OS=...4161e-26     114     28     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
374Q9AQC8    126   LEU3_BUCUL 3-isopropylmalate dehydrogenase OS...1180.000000000000002     76.6     40     63GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
375P50217    416   IDHC_SOLTU Isocitrate dehydrogenase [NADP] OS...2060.000000008     60.5     28     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
376P50218    415   IDHC_TOBAC Isocitrate dehydrogenase [NADP] OS...2060.00000002     59.3     28     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
377P33198    421   IDHP_PIG Isocitrate dehydrogenase [NADP], mit...1480.00000003     58.9     31     51GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
378P50215    406   IDH_SPHYA Isocitrate dehydrogenase [NADP] OS=...1640.0000001     56.6     30     48
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
379P21954    428   IDHP_YEAST Isocitrate dehydrogenase [NADP], m...1150.0000002     56.2     32     54GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006537; P:glutamate biosynthetic process; IMP:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
380Q4R502    452   IDHP_MACFA Isocitrate dehydrogenase [NADP], m...1500.0000002     55.8     30     51GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
381P79089    498   IDHP_ASPNG Isocitrate dehydrogenase [NADP], m...1280.0000003     55.8     33     52GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
382P48735    452   IDHP_HUMAN Isocitrate dehydrogenase [NADP], m...1500.0000003     55.8     30     51GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
383Q40345    433   IDHP_MEDSA Isocitrate dehydrogenase [NADP], c...2070.0000003     55.5     30     46GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
384P54071    452   IDHP_MOUSE Isocitrate dehydrogenase [NADP], m...1480.0000003     55.5     30     51GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
385P56574    452   IDHP_RAT Isocitrate dehydrogenase [NADP], mit...1480.0000006     54.7     30     51
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
386O14254    439   IDHP_SCHPO Probable isocitrate dehydrogenase ...2190.0000006     54.7     27     45GO:0005739; C:mitochondrion; IDA:PomBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006537; P:glutamate biosynthetic process; ISS:PomBase.::GO:0006102; P:isocitrate metabolic process; ISS:PomBase.::GO:0006740; P:NADPH regeneration; ISS:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IC:PomBase.
387Q04467    452   IDHP_BOVIN Isocitrate dehydrogenase [NADP], m...1480.000001     53.9     30     50GO:0005743; C:mitochondrial inner membrane; ISS:AgBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
388Q9XSG3    414   IDHC_BOVIN Isocitrate dehydrogenase [NADP] cy...1280.000001     53.5     31     52GO:0005829; C:cytosol; ISS:AgBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; ISS:AgBase.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:AgBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
389Q06197    413   IDHC_SOYBN Isocitrate dehydrogenase [NADP] OS...1710.000001     53.5     29     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
390P41562    414   IDHC_RAT Isocitrate dehydrogenase [NADP] cyto...1280.000001     53.5     31     52GO:0005777; C:peroxisome; IDA:HGNC.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050661; F:NADP binding; IDA:RGD.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0008585; P:female gonad development; IEP:RGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0014070; P:response to organic cyclic compound; IDA:RGD.::GO:0048545; P:response to steroid hormone stimulus; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
391Q75JR3    412   IDHC_DICDI Isocitrate dehydrogenase [NADP] cy...1040.000002     53.1     32     53GO:0005829; C:cytosol; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
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