Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YIL094C
Length:
371
Number of sequences:
5887
Description:
YIL094C LYS12 SGDID:S000001356, Chr IX from 187632-186517, Genome Release 64-1-1, reverse complement, Verified ORF, "Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121Q5M405    345   LEU3_STRT2 3-isopropylmalate dehydrogenase OS...3649e-48     171     37     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
122Q5LZF3    345   LEU3_STRT1 3-isopropylmalate dehydrogenase OS...3649e-48     171     37     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
123Q48806    615   DLPA_LEGPH Protein dlpA OS=ATCC 33152 / DSM 7...3701e-47     176     32     52
GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
124Q21CS1    370   LEU3_RHOPB 3-isopropylmalate dehydrogenase OS...3551e-47     171     36     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
125Q2T7H6    355   LEU3_BURTA 3-isopropylmalate dehydrogenase OS...3521e-47     171     37     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
126Q93353    379   IDH3B_CAEEL Probable isocitrate dehydrogenase...3561e-47     171     33     52GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
127Q5E857    363   LEU3_VIBF1 3-isopropylmalate dehydrogenase OS...3521e-47     171     36     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
128Q24XT2    352   LEU3_DESHY 3-isopropylmalate dehydrogenase OS...3453e-47     169     36     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
129Q8XXX5    356   LEU3_RALSO 3-isopropylmalate dehydrogenase OS...3503e-47     169     37     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
130Q2KYL5    358   LEU3_BORA1 3-isopropylmalate dehydrogenase OS...3715e-47     169     36     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
131Q3IJS3    358   LEU3_PSEHT 3-isopropylmalate dehydrogenase OS...3735e-47     169     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
132Q3AIH4    357   LEU3_SYNSC 3-isopropylmalate dehydrogenase OS...3485e-47     169     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
133Q7N128    363   LEU3_PHOLL 3-isopropylmalate dehydrogenase OS...3495e-47     169     35     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
134P41565    393   IDHG1_RAT Isocitrate dehydrogenase [NAD] subu...3516e-47     170     33     53GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IC:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006734; P:NADH metabolic process; IDA:RGD.::GO:0045926; P:negative regulation of growth; IMP:RGD.::GO:0006099; P:tricarboxylic acid cycle; IDA:RGD.
135P70404    393   IDHG1_MOUSE Isocitrate dehydrogenase [NAD] su...3516e-47     169     33     53GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
136P93832    405   LEU32_ARATH 3-isopropylmalate dehydrogenase 2...3737e-47     170     34     53GO:0009941; C:chloroplast envelope; IDA:TAIR.::GO:0009570; C:chloroplast stroma; IDA:TAIR.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IGI:TAIR.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IGI:TAIR.
137P41564    355   IDH3G_MACFA Isocitrate dehydrogenase [NAD] su...3518e-47     168     32     53GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
138Q9KP82    363   LEU3_VIBCH 3-isopropylmalate dehydrogenase OS...3709e-47     169     34     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
139Q5KWJ4    371   LEU3_GEOKA 3-isopropylmalate dehydrogenase OS...3641e-46     169     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
140Q7MP78    363   LEU3_VIBVY 3-isopropylmalate dehydrogenase OS...3521e-46     168     35     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
141Q5P1J6    350   LEU3_AROAE 3-isopropylmalate dehydrogenase OS...3671e-46     168     34     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
142Q8A6M0    353   LEU3_BACTN 3-isopropylmalate dehydrogenase OS...3591e-46     168     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
143Q8P5L1    357   LEU3_XANCP 3-isopropylmalate dehydrogenase OS...3151e-46     168     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
144Q4UYG2    357   LEU3_XANC8 3-isopropylmalate dehydrogenase OS...3151e-46     168     37     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
145Q2SJD6    360   LEU3_HAHCH 3-isopropylmalate dehydrogenase OS...3131e-46     168     36     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
146Q726X1    357   LEU3_DESVH 3-isopropylmalate dehydrogenase OS...3201e-46     168     37     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
147Q2JL30    371   LEU3_SYNJB 3-isopropylmalate dehydrogenase OS...3581e-46     168     37     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
148Q5LWZ5    367   LEU3_SILPO 3-isopropylmalate dehydrogenase OS...3681e-46     168     34     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
149P51553    393   IDH3G_HUMAN Isocitrate dehydrogenase [NAD] su...3512e-46     169     33     53GO:0005759; C:mitochondrial matrix; TAS:Reactome.::GO:0005730; C:nucleolus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
150Q1LKH7    355   LEU3_RALME 3-isopropylmalate dehydrogenase OS...3522e-46     167     36     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
151Q8G500    343   LEU3_BIFLO 3-isopropylmalate dehydrogenase OS...3612e-46     167     34     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
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