Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YIL002C
Length:
946
Number of sequences:
5887
Description:
YIL002C INP51 SGDID:S000001264, Chr IX from 353431-350591, Genome Release 64-1-1, reverse complement, Verified ORF, "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q6P4S2    1019   SHIP1_XENLA Phosphatidylinositol 3,4,5-trisph...3425e-31     135     30     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
32A0FI79    644   INP5E_PANTR 72 kDa inositol polyphosphate 5-p...3272e-30     132     29     46GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
33Q9NRR6    644   INP5E_HUMAN 72 kDa inositol polyphosphate 5-p...3272e-30     132     29     46GO:0035085; C:cilium axoneme; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:UniProtKB.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
34O15357    1258   SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisph...3423e-30     133     29     44GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006897; P:endocytosis; IMP:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
35Q6P549    1257   SHIP2_MOUSE Phosphatidylinositol 3,4,5-trisph...3423e-30     133     29     44GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006006; P:glucose metabolic process; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.::GO:0010629; P:negative regulation of gene expression; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0032868; P:response to insulin stimulus; IMP:MGI.
36Q9WVR3    1257   SHIP2_RAT Phosphatidylinositol 3,4,5-trisphos...3423e-30     133     29     44GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:RGD.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007420; P:brain development; IEP:RGD.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0032957; P:inositol trisphosphate metabolic process; IDA:RGD.::GO:0008156; P:negative regulation of DNA replication; IMP:RGD.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:RGD.::GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:RGD.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:RGD.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0042493; P:response to drug; IEP:RGD.
37Q2I6J1    1266   SHP2A_DANRE Phosphatidylinositol 3,4,5-trisph...3418e-30     131     28     46GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0030509; P:BMP signaling pathway; IMP:ZFIN.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IMP:ZFIN.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
38Q92835    1189   SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisph...3451e-29     130     30     45GO:0005829; C:cytosol; TAS:Reactome.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
39P97573    1190   SHIP1_RAT Phosphatidylinositol 3,4,5-trisphos...3442e-29     130     30     46GO:0005884; C:actin filament; IDA:RGD.::GO:0030863; C:cortical cytoskeleton; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0030487; F:inositol-4,5-bisphosphate 5-phosphatase activity; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
40Q9ES52    1191   SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisph...3443e-29     129     30     46GO:0005622; C:intracellular; IMP:GOC.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:MGI.::GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0051425; F:PTB domain binding; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008340; P:determination of adult lifespan; IMP:MGI.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0050869; P:negative regulation of B cell activation; IMP:MGI.::GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.::GO:0045779; P:negative regulation of bone resorption; IMP:MGI.::GO:0050777; P:negative regulation of immune response; IMP:MGI.::GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IMP:MGI.::GO:0045656; P:negative regulation of monocyte differentiation; IMP:MGI.::GO:0045659; P:negative regulation of neutrophil differentiation; IMP:MGI.::GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.::GO:0009968; P:negative regulation of signal transduction; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.::GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.::GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:MGI.
41Q9BT40    448   INP5K_HUMAN Inositol polyphosphate 5-phosphat...2813e-29     125     34     49GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0043005; C:neuron projection; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0016312; F:inositol bisphosphate phosphatase activity; IDA:UniProtKB.::GO:0046030; F:inositol trisphosphate phosphatase activity; IDA:MGI.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0042577; F:lipid phosphatase activity; NAS:UniProtKB.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005000; F:vasopressin receptor activity; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IDA:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; ISS:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; IDA:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; ISS:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; IDA:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; IDA:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; ISS:UniProtKB.::GO:0097178; P:ruffle assembly; IDA:UniProtKB.
42Q2I6J0    1226   SHP2B_DANRE Phosphatidylinositol 3,4,5-trisph...3343e-27     123     25     46GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
43P34370    398   YLJ7_CAEEL Uncharacterized protein C50C3.7 OS...2681e-25     114     30     49
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
44Q08227    384   INP54_YEAST Phosphatidylinositol 4,5-bisphosp...3191e-19     95.9     28     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
45A1L244    586   SAC1A_DANRE Phosphatidylinositide phosphatase...5045e-18     92.4     24     40GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
46Q6GM29    586   SAC1_XENLA Phosphatidylinositide phosphatase ...4152e-17     90.9     24     41GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
47A4VCH0    586   SAC1B_DANRE Phosphatidylinositide phosphatase...4988e-16     85.5     23     39GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
48Q55AW9    581   SAC1_DICDI Phosphatidylinositide phosphatase ...3140.000000000000001     84.7     26     45GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; ISS:dictyBase.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:dictyBase.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; ISS:dictyBase.
GO:0048017; P:inositol lipid-mediated signaling; ISS:dictyBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:dictyBase.
49A8E7C5    1120   SAC2_DANRE Phosphatidylinositide phosphatase ...4090.00000000000001     82     20     42
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
50Q9EP69    587   SAC1_MOUSE Phosphatidylinositide phosphatase ...5010.00000000000002     81.3     23     40
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
51Q9ES21    587   SAC1_RAT Phosphatidylinositide phosphatase SA...5000.0000000000001     78.6     23     39GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:RGD.
GO:0034593; F:phosphatidylinositol bisphosphate phosphatase activity; IDA:RGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:RGD.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:RGD.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:RGD.
52O60162    598   YG23_SCHPO Uncharacterized protein C19F5.03 O...3490.0000000000005     76.6     24     42GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:PomBase.::GO:0030173; C:integral to Golgi membrane; ISS:PomBase.::GO:0005741; C:mitochondrial outer membrane; ISS:PomBase.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; ISS:PomBase.
53Q5R921    587   SAC1_PONAB Phosphatidylinositide phosphatase ...5010.0000000000005     76.6     23     38GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
54Q9NTJ5    587   SAC1_HUMAN Phosphatidylinositide phosphatase ...5010.0000000000006     76.3     23     38GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
55A6QL88    587   SAC1_BOVIN Phosphatidylinositide phosphatase ...3940.000000000001     75.1     23     40GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016791; F:phosphatase activity; ISS:UniProtKB.
56P32368    623   SAC1_YEAST Phosphoinositide phosphatase SAC1 ...4590.000000000003     73.9     22     41GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.::GO:0030173; C:integral to Golgi membrane; IDA:SGD.::GO:0005741; C:mitochondrial outer membrane; IDA:SGD.::GO:0035339; C:SPOTS complex; IDA:UniProtKB.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:SGD.::GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.
57Q7Z9H9    832   FIG4_SCHPO Polyphosphoinositide phosphatase O...4260.00000000001     72     25     41GO:0005829; C:cytosol; IDA:PomBase.::GO:0019898; C:extrinsic to membrane; ISS:PomBase.::GO:0000329; C:fungal-type vacuole membrane; ISS:PomBase.
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
GO:0000753; P:cell morphogenesis involved in conjugation with cellular fusion; ISS:PomBase.::GO:0046488; P:phosphatidylinositol metabolic process; NAS:PomBase.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:PomBase.
58Q8CDA1    1132   SAC2_MOUSE Phosphatidylinositide phosphatase ...2670.00000000007     70.1     22     41
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
59P42837    879   FIG4_YEAST Polyphosphoinositide phosphatase O...4230.0000000002     68.6     23     40GO:0019898; C:extrinsic to membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0070772; C:PAS complex; IDA:SGD.
GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.
60Q9W0I6    592   SAC1_DROME Phosphatidylinositide phosphatase ...3380.0000000002     67.8     21     40GO:0030424; C:axon; IDA:FlyBase.::GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0043025; C:neuronal cell body; IDA:FlyBase.::GO:0071683; C:sensory dendrite; IDA:FlyBase.
GO:0052866; F:phosphatidylinositol phosphate phosphatase activity; IDA:FlyBase.
GO:0016199; P:axon midline choice point recognition; IMP:FlyBase.::GO:0046664; P:dorsal closure, amnioserosa morphology change; IMP:FlyBase.::GO:0046329; P:negative regulation of JNK cascade; IMP:FlyBase.
61Q9Y2H2    1132   SAC2_HUMAN Phosphatidylinositide phosphatase ...2670.000000002     65.5     20     42
GO:0042578; F:phosphoric ester hydrolase activity; IEA:InterPro.
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