Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHR119W
Length:
1080
Number of sequences:
5887
Description:
YHR119W SET1 SGDID:S000001161, Chr VIII from 346043-349285, Genome Release 64-1-1, Verified ORF, "Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q9M364    1018   ATX3_ARATH Histone-lysine N-methyltransferase...1433e-37     155     52     67GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
32Q8IRW8    2431   TRR_DROME Histone-lysine N-methyltransferase ...1415e-37     155     52     69GO:0005634; C:nucleus; IDA:FlyBase.::GO:0005700; C:polytene chromosome; IDA:FlyBase.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:FlyBase.::GO:0005102; F:receptor binding; IPI:FlyBase.::GO:0003713; F:transcription coactivator activity; IGI:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IGI:FlyBase.::GO:0007458; P:progression of morphogenetic furrow involved in compound eye morphogenesis; IMP:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
33Q24742    3828   TRX_DROVI Histone-lysine N-methyltransferase ...1413e-36     153     50     67GO:0035097; C:histone methyltransferase complex; IEA:InterPro.
GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:InterPro.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
34Q03164    3969   MLL1_HUMAN Histone-lysine N-methyltransferase...1441e-35     152     51     65GO:0071339; C:MLL1 complex; IDA:UniProtKB.
GO:0003680; F:AT DNA binding; NAS:UniProtKB.::GO:0070577; F:histone acetyl-lysine binding; IDA:UniProtKB.::GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.::GO:0045322; F:unmethylated CpG binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035162; P:embryonic hemopoiesis; TAS:UniProtKB.::GO:0080182; P:histone H3-K4 trimethylation; IDA:BHF-UCL.::GO:0043984; P:histone H4-K16 acetylation; IMP:UniProtKB.::GO:2001040; P:positive regulation of cellular response to drug; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0032411; P:positive regulation of transporter activity; IMP:BHF-UCL.::GO:0006461; P:protein complex assembly; IDA:UniProtKB.::GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
35P55200    3966   MLL1_MOUSE Histone-lysine N-methyltransferase...1442e-35     150     51     65GO:0071339; C:MLL1 complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0070577; F:histone acetyl-lysine binding; ISS:UniProtKB.::GO:0042800; F:histone methyltransferase activity (H3-K4 specific); ISS:UniProtKB.::GO:0045322; F:unmethylated CpG binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.::GO:0006306; P:DNA methylation; IMP:MGI.::GO:0035162; P:embryonic hemopoiesis; IMP:MGI.::GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0051569; P:regulation of histone H3-K4 methylation; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
36O08550    2713   MLL4_MOUSE Histone-lysine N-methyltransferase...1444e-34     146     53     66GO:0035097; C:histone methyltransferase complex; IDA:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016458; P:gene silencing; IMP:MGI.::GO:0080182; P:histone H3-K4 trimethylation; IMP:MGI.::GO:0009994; P:oocyte differentiation; IMP:MGI.::GO:0001541; P:ovarian follicle development; IMP:MGI.::GO:0030728; P:ovulation; IMP:MGI.::GO:0051569; P:regulation of histone H3-K4 methylation; IMP:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
37Q9UMN6    2715   MLL4_HUMAN Histone-lysine N-methyltransferase...1445e-34     146     53     66
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0048096; P:chromatin-mediated maintenance of transcription; NAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
38P0CB22    1083   ATX2_ARATH Histone-lysine N-methyltransferase...1714e-33     142     42     62GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IMP:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IMP:TAIR.
39C6KTD2    6753   HKNMT_PLAF7 Putative histone-lysine N-methylt...1383e-32     140     49     68
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
40Q8NEZ4    4911   MLL3_HUMAN Histone-lysine N-methyltransferase...1411e-30     135     48     62
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
41Q8BRH4    4903   MLL3_MOUSE Histone-lysine N-methyltransferase...1412e-30     135     48     62GO:0035097; C:histone methyltransferase complex; IDA:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
42Q9C5X4    1062   ATX1_ARATH Histone-lysine N-methyltransferase...1458e-30     132     44     63GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0018024; F:histone-lysine N-methyltransferase activity; IDA:TAIR.::GO:0010314; F:phosphatidylinositol-5-phosphate binding; IDA:TAIR.::GO:0044212; F:transcription regulatory region DNA binding; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051568; P:histone H3-K4 methylation; IDA:TAIR.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009909; P:regulation of flower development; IMP:TAIR.::GO:0006355; P:regulation of transcription, DNA-dependent; IMP:TAIR.::GO:0010093; P:specification of floral organ identity; IMP:TAIR.
43Q84WW6    492   ASHH1_ARATH Histone-lysine N-methyltransferas...1324e-26     117     44     58GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:TAIR.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006281; P:DNA repair; IMP:TAIR.::GO:0010224; P:response to UV-B; IEP:TAIR.::GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
44Q6PDK2    5588   MLL2_MOUSE Histone-lysine N-methyltransferase...1445e-25     117     47     62
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; IMP:UniProtKB.::GO:0051568; P:histone H3-K4 methylation; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0001555; P:oocyte growth; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
45O14686    5537   MLL2_HUMAN Histone-lysine N-methyltransferase...1445e-25     117     47     62GO:0035097; C:histone methyltransferase complex; IPI:MGI.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; ISS:UniProtKB.::GO:0051568; P:histone H3-K4 methylation; ISS:UniProtKB.::GO:0001555; P:oocyte growth; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0043627; P:response to estrogen stimulus; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
46Q7RZU4    954   SET2_NEUCR Histone-lysine N-methyltransferase...1518e-25     115     39     54GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
47O88491    2588   NSD1_MOUSE Histone-lysine N-methyltransferase...1499e-24     112     39     54GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0035097; C:histone methyltransferase complex; IC:UniProtKB.
GO:0050681; F:androgen receptor binding; ISS:UniProtKB.::GO:0030331; F:estrogen receptor binding; IPI:UniProtKB.::GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IDA:UniProtKB.::GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IDA:UniProtKB.::GO:0016922; F:ligand-dependent nuclear receptor binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0046965; F:retinoid X receptor binding; IPI:UniProtKB.::GO:0046966; F:thyroid hormone receptor binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
48Q96L73    2696   NSD1_HUMAN Histone-lysine N-methyltransferase...1491e-23     112     39     54GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IDA:UniProtKB.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0030331; F:estrogen receptor binding; ISS:UniProtKB.::GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IDA:UniProtKB.::GO:0042799; F:histone methyltransferase activity (H4-K20 specific); ISS:UniProtKB.::GO:0016922; F:ligand-dependent nuclear receptor binding; ISS:UniProtKB.::GO:0046965; F:retinoid X receptor binding; ISS:UniProtKB.::GO:0046966; F:thyroid hormone receptor binding; ISS:UniProtKB.::GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
49Q4PBL3    972   SET2_USTMA Histone-lysine N-methyltransferase...1764e-23     110     37     50GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
50Q2UTN6    965   SET2_ASPOR Histone-lysine N-methyltransferase...1765e-23     109     35     49GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
51P0CO29    834   SET2_CRYNB Histone-lysine N-methyltransferase...1321e-22     108     39     55GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
52P0CO28    834   SET2_CRYNJ Histone-lysine N-methyltransferase...1321e-22     108     39     55GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
53Q1DU03    1003   SET2_COCIM Histone-lysine N-methyltransferase...1411e-22     108     38     54GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
54Q2H988    894   SET2_CHAGB Histone-lysine N-methyltransferase...1522e-22     107     38     53GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
55Q9BZ95    1437   NSD3_HUMAN Histone-lysine N-methyltransferase...1983e-22     107     34     48GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IC:UniProtKB.
GO:0018024; F:histone-lysine N-methyltransferase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; NAS:UniProtKB.::GO:0016049; P:cell growth; NAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
56Q5ASA5    980   SET2_EMENI Histone-lysine N-methyltransferase...1413e-22     107     38     53GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
57Q9BYW2    2564   SETD2_HUMAN Histone-lysine N-methyltransferas...1764e-22     107     31     49GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
58Q4WTT2    966   SET2_ASPFU Histone-lysine N-methyltransferase...2214e-22     106     31     48GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
59Q949T8    497   ASHR3_ARATH Histone-lysine N-methyltransferas...2678e-22     103     28     49GO:0000785; C:chromatin; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
60Q6P2L6    1439   NSD3_MOUSE Histone-lysine N-methyltransferase...1989e-22     105     35     48GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
61Q6C5G5    768   SET2_YARLI Histone-lysine N-methyltransferase...1329e-22     105     42     52GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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