Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHR114W
Length:
633
Number of sequences:
5887
Description:
YHR114W BZZ1 SGDID:S000001156, Chr VIII from 338083-339984, Genome Release 64-1-1, Verified ORF, "SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
241Q3KR97    516   BI2L1_RAT Brain-specific angiogenesis inhibit...400.19     38.5     40     65GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0070064; F:proline-rich region binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro.
GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; ISS:UniProtKB.::GO:0009617; P:response to bacterium; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
242Q6TGW5    214   OSTF1_DANRE Osteoclast-stimulating factor 1 O...530.19     37.7     32     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
243P87379    229   GRB2A_XENLA Growth factor receptor-bound prot...620.2     37.7     31     53GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
244Q5A895    498   HSE1_CANAL Class E vacuolar protein-sorting m...680.19     38.5     34     46GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
245Q5VV41    709   ARHGG_HUMAN Rho guanine nucleotide exchange f...540.19     38.5     33     57GO:0005829; C:cytosol; TAS:Reactome.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.::GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
246P20929    6669   NEBU_HUMAN Nebulin OS=Homo sapiens (Human). G...630.33     38.1     32     44GO:0015629; C:actin cytoskeleton; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030018; C:Z disc; IDA:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
GO:0030049; P:muscle filament sliding; TAS:Reactome.::GO:0007517; P:muscle organ development; TAS:ProtInc.::GO:0030832; P:regulation of actin filament length; NAS:UniProtKB.::GO:0007525; P:somatic muscle development; NAS:UniProtKB.
247O43639    380   NCK2_HUMAN Cytoplasmic protein NCK2 OS=Homo s...1440.2     38.1     20     44GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0008093; F:cytoskeletal adaptor activity; NAS:UniProtKB.::GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.::GO:0030838; P:positive regulation of actin filament polymerization; IMP:UniProtKB.::GO:0042102; P:positive regulation of T cell proliferation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; TAS:ProtInc.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0007172; P:signal complex assembly; NAS:UniProtKB.::GO:0042110; P:T cell activation; NAS:UniProtKB.
248Q9UQB8    552   BAIP2_HUMAN Brain-specific angiogenesis inhib...560.2     38.5     36     63GO:0030054; C:cell junction; IDA:HPA.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0008093; F:cytoskeletal adaptor activity; TAS:ProtInc.::GO:0070064; F:proline-rich region binding; IDA:UniProtKB.::GO:0008022; F:protein C-terminus binding; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:InterPro.
GO:0007409; P:axonogenesis; TAS:ProtInc.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0008286; P:insulin receptor signaling pathway; TAS:ProtInc.::GO:0032956; P:regulation of actin cytoskeleton organization; IMP:UniProtKB.::GO:0009617; P:response to bacterium; IMP:UniProtKB.
249Q8N5V2    710   NGEF_HUMAN Ephexin-1 OS=Homo sapiens (Human)....510.2     38.5     33     61GO:0005829; C:cytosol; TAS:Reactome.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
250O75886    525   STAM2_HUMAN Signal transducing adapter molecu...520.21     38.1     37     60GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0016197; P:endosome transport; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
251Q6XJU9    214   OSTF1_MONAL Osteoclast-stimulating factor 1 O...530.21     37.4     30     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
252Q5RDX5    709   NGEF_PONAB Ephexin-1 OS=Pongo abelii (Sumatra...510.21     38.5     33     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
253P43603    459   LSB3_YEAST LAS seventeen-binding protein 3 OS...850.22     38.1     31     54GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0051666; P:actin cortical patch localization; IMP:SGD.
254A7A261    459   LSB3_YEAS7 LAS seventeen-binding protein 3 OS...850.22     38.1     31     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
255P53281    241   LSB1_YEAST LAS seventeen-binding protein 1 OS...520.22     37.7     37     58GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
256Q5U2U2    303   CRKL_RAT Crk-like protein OS=Rattus norvegicu...1670.22     37.7     22     40
257Q3B7M5    260   LASP1_BOVIN LIM and SH3 domain protein 1 OS=B...510.73     36.2     43     57GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.
258Q9DBJ3    514   BI2L1_MOUSE Brain-specific angiogenesis inhib...1129.5     33.1     26     44GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0070064; F:proline-rich region binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro.
GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; ISS:UniProtKB.::GO:0009617; P:response to bacterium; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
259Q5R5W0    261   LASP1_PONAB LIM and SH3 domain protein 1 OS=P...510.6     36.2     43     57GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.
260Q8WV41    574   SNX33_HUMAN Sorting nexin-33 OS=Homo sapiens ...560.25     38.1     30     57
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0007154; P:cell communication; IEA:InterPro.
261Q5TCZ1    1133   SPD2A_HUMAN SH3 and PX domain-containing prot...1530.25     38.1     27     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0002102; C:podosome; IDA:UniProtKB.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0006801; P:superoxide metabolic process; IDA:UniProtKB.
262P46109    303   CRKL_HUMAN Crk-like protein OS=Homo sapiens (...1670.25     37.7     22     40GO:0005829; C:cytosol; TAS:Reactome.
GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; TAS:ProtInc.
GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.
263P00530    873   FPS_FUJSV Tyrosine-protein kinase transformin...2660.25     38.1     18     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:InterPro.::GO:0016032; P:viral reproduction; IEA:InterPro.
264O93436    468   STAM2_CHICK Signal transducing adapter molecu...530.27     37.7     36     60GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
265Q14847    261   LASP1_HUMAN LIM and SH3 domain protein 1 OS=H...510.72     36.2     43     57GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.
GO:0015075; F:ion transmembrane transporter activity; ISS:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
266Q6DTM3    1047   AHI1_RAT Jouberin OS=Rattus norvegicus (Rat)....890.28     38.1     29     43GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; ISS:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
267Q86UR1    476   NOXA1_HUMAN NADPH oxidase activator 1 OS=Homo...480.28     37.7     35     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043020; C:NADPH oxidase complex; IDA:BHF-UCL.
GO:0048365; F:Rac GTPase binding; IPI:BHF-UCL.::GO:0017124; F:SH3 domain binding; IPI:UniProtKB.::GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:UniProtKB.
GO:0010310; P:regulation of hydrogen peroxide metabolic process; IMP:BHF-UCL.::GO:0060263; P:regulation of respiratory burst; IMP:BHF-UCL.::GO:0006801; P:superoxide metabolic process; IMP:UniProtKB.
268P16885    1265   PLCG2_HUMAN 1-phosphatidylinositol 4,5-bispho...560.28     38.1     30     57GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; TAS:UniProtKB.
269Q9R1Z8    733   VINEX_MOUSE Vinexin OS=Mus musculus (Mouse). ...1371.9     35.4     23     43GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0008134; F:transcription factor binding; IPI:MGI.
GO:0031589; P:cell-substrate adhesion; IDA:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
270Q8TDY4    903   ASAP3_HUMAN Arf-GAP with SH3 domain, ANK repe...1610.29     38.1     24     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
271Q9BX66    1292   SRBS1_HUMAN Sorbin and SH3 domain-containing ...675.2     33.9     27     51GO:0005813; C:centrosome; IDA:HPA.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0005925; C:focal adhesion; IDA:HPA.::GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0001725; C:stress fiber; ISS:UniProtKB.::GO:0005915; C:zonula adherens; TAS:ProtInc.
GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005158; F:insulin receptor binding; IDA:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; ISS:BHF-UCL.
GO:0048041; P:focal adhesion assembly; ISS:UniProtKB.::GO:0015758; P:glucose transport; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0006936; P:muscle contraction; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; ISS:BHF-UCL.::GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:BHF-UCL.::GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:BHF-UCL.::GO:0043149; P:stress fiber assembly; ISS:UniProtKB.
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