Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHR114W
Length:
633
Number of sequences:
5887
Description:
YHR114W BZZ1 SGDID:S000001156, Chr VIII from 338083-339984, Genome Release 64-1-1, Verified ORF, "SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
151O94875    1100   SRBS2_HUMAN Sorbin and SH3 domain-containing ...1490.03     41.2     27     41GO:0015629; C:actin cytoskeleton; TAS:ProtInc.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005634; C:nucleus; NAS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; NAS:UniProtKB.
GO:0008093; F:cytoskeletal adaptor activity; TAS:ProtInc.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.::GO:0008307; F:structural constituent of muscle; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
152Q6YKA8    211   DRK_DROSI Protein E(sev)2B OS=Drosophila simu...600.29     37     33     50GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005070; F:SH3/SH2 adaptor activity; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
153Q08012    211   DRK_DROME Protein enhancer of sevenless 2B OS...600.29     37     33     50GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0005118; F:sevenless binding; IPI:FlyBase.::GO:0005070; F:SH3/SH2 adaptor activity; NAS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0007256; P:activation of JNKK activity; NAS:UniProtKB.::GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IGI:FlyBase.::GO:0008355; P:olfactory learning; IMP:FlyBase.::GO:0045678; P:positive regulation of R7 cell differentiation; IGI:FlyBase.::GO:0007265; P:Ras protein signal transduction; IPI:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0045500; P:sevenless signaling pathway; IGI:FlyBase.::GO:0007614; P:short-term memory; IMP:FlyBase.::GO:0008293; P:torso signaling pathway; TAS:FlyBase.
154Q71F54    894   SH3R1_RAT E3 ubiquitin-protein ligase SH3RF1 ...610.016     42     34     54GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006917; P:induction of apoptosis; IMP:RGD.
155O43150    1006   ASAP2_HUMAN Arf-GAP with SH3 domain, ANK repe...710.016     42     34     52GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
156O55043    646   ARHG7_RAT Rho guanine nucleotide exchange fac...503     34.7     30     54GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0043615; P:astrocyte cell migration; IMP:RGD.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:RGD.
157O75791    330   GRAP2_HUMAN GRB2-related adapter protein 2 OS...540.019     41.2     37     54GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
158Q8TEJ3    882   SH3R3_HUMAN SH3 domain-containing RING finger...1000.22     38.5     29     47
GO:0008270; F:zinc ion binding; IEA:InterPro.
159Q96HU1    749   SGSM3_HUMAN Small G protein signaling modulat...520.02     41.6     37     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.::GO:0017137; F:Rab GTPase binding; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.::GO:0032486; P:Rap protein signal transduction; IEP:UniProtKB.
160Q15052    776   ARHG6_HUMAN Rho guanine nucleotide exchange f...830.25     38.1     28     49GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; NAS:UniProtKB.
GO:0006915; P:apoptotic process; NAS:UniProtKB.::GO:0034329; P:cell junction assembly; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0007254; P:JNK cascade; NAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
161Q1LYG0    1119   SPD2A_DANRE SH3 and PX domain-containing prot...1540.021     42     25     45GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0002102; C:podosome; ISS:UniProtKB.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0006801; P:superoxide metabolic process; ISS:UniProtKB.
162Q14155    803   ARHG7_HUMAN Rho guanine nucleotide exchange f...801.7     35.4     28     51GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:BHF-UCL.::GO:0043025; C:neuronal cell body; IDA:BHF-UCL.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043547; P:positive regulation of GTPase activity; IDA:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
163Q5XXR3    772   ARHG6_RAT Rho guanine nucleotide exchange fac...870.55     37     26     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
164A6QLK6    217   GRAP_BOVIN GRB2-related adapter protein OS=Bo...534.4     33.5     28     47
165O88811    523   STAM2_MOUSE Signal transducing adapter molecu...640.021     41.6     36     56GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
166Q2KI13    747   SGSM3_BOVIN Small G protein signaling modulat...520.022     41.6     37     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.::GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.
GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.::GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.
167P70297    548   STAM1_MOUSE Signal transducing adapter molecu...520.022     41.6     38     62GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:MGI.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
168Q69ZI1    892   SH3R1_MOUSE E3 ubiquitin-protein ligase SH3RF...610.022     41.6     34     52GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005078; F:MAP-kinase scaffold activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0046328; P:regulation of JNK cascade; IDA:MGI.
169Q63768    304   CRK_RAT Adapter molecule crk OS=Rattus norveg...1580.023     40.8     22     42GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0007257; P:activation of JUN kinase activity; TAS:RGD.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0051270; P:regulation of cellular component movement; TAS:RGD.::GO:0035020; P:regulation of Rac protein signal transduction; IMP:RGD.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
170P46108    304   CRK_HUMAN Adapter molecule crk OS=Homo sapien...1580.023     40.8     22     42GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome.::GO:0005634; C:nucleus; TAS:ProtInc.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0032956; P:regulation of actin cytoskeleton organization; IDA:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; IDA:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
171Q9ES28    862   ARHG7_MOUSE Rho guanine nucleotide exchange f...503.2     34.7     30     54GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
172O94478    420   MU137_SCHPO Meiotically up-regulated gene 137...760.023     41.2     30     46GO:0032153; C:cell division site; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0007126; P:meiosis; IEP:PomBase.
173Q8K4I3    771   ARHG6_MOUSE Rho guanine nucleotide exchange f...790.6     37     28     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
174O55033    380   NCK2_MOUSE Cytoplasmic protein NCK2 OS=Mus mu...1420.024     41.2     22     44GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; IDA:MGI.
GO:0007015; P:actin filament organization; IMP:MGI.::GO:0016477; P:cell migration; IMP:MGI.::GO:0030032; P:lamellipodium assembly; IMP:MGI.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
175D3YZU1    2167   SHAN1_MOUSE SH3 and multiple ankyrin repeat d...550.025     41.6     38     60GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; IDA:BHF-UCL.::GO:0014069; C:postsynaptic density; IDA:BHF-UCL.::GO:0045211; C:postsynaptic membrane; IDA:MGI.::GO:0019717; C:synaptosome; IDA:BHF-UCL.
GO:0071532; F:ankyrin repeat binding; ISS:BHF-UCL.::GO:0030160; F:GKAP/Homer scaffold activity; IMP:BHF-UCL.::GO:0042802; F:identical protein binding; ISS:BHF-UCL.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:BHF-UCL.::GO:0097110; F:scaffold protein binding; ISS:BHF-UCL.::GO:0017124; F:SH3 domain binding; ISS:BHF-UCL.
GO:0008306; P:associative learning; IMP:BHF-UCL.::GO:0060997; P:dendritic spine morphogenesis; IMP:BHF-UCL.::GO:0046959; P:habituation; IMP:BHF-UCL.::GO:0007616; P:long-term memory; IMP:BHF-UCL.::GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:MGI.::GO:0050885; P:neuromuscular process controlling balance; IMP:BHF-UCL.::GO:0042048; P:olfactory behavior; IMP:BHF-UCL.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.::GO:0006461; P:protein complex assembly; ISS:BHF-UCL.::GO:0035418; P:protein localization to synapse; IMP:BHF-UCL.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:BHF-UCL.::GO:0060013; P:righting reflex; IMP:BHF-UCL.::GO:0035176; P:social behavior; IMP:BHF-UCL.::GO:0071625; P:vocalization behavior; IMP:BHF-UCL.
176Q64010    304   CRK_MOUSE Adapter molecule crk OS=Mus musculu...1580.025     40.8     22     42GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0045309; F:protein phosphorylated amino acid binding; IDA:MGI.::GO:0005070; F:SH3/SH2 adaptor activity; IPI:BHF-UCL.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
177Q9WV48    2167   SHAN1_RAT SH3 and multiple ankyrin repeat dom...550.025     41.6     38     60GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; ISS:BHF-UCL.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL.::GO:0045211; C:postsynaptic membrane; IDA:RGD.
GO:0071532; F:ankyrin repeat binding; IPI:BHF-UCL.::GO:0030160; F:GKAP/Homer scaffold activity; IDA:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:RGD.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0097110; F:scaffold protein binding; IPI:BHF-UCL.::GO:0017124; F:SH3 domain binding; IPI:BHF-UCL.::GO:0031877; F:somatostatin receptor binding; IPI:UniProtKB.
GO:0008306; P:associative learning; ISS:BHF-UCL.::GO:0007016; P:cytoskeletal anchoring at plasma membrane; NAS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:BHF-UCL.::GO:0007616; P:long-term memory; ISS:BHF-UCL.::GO:0050885; P:neuromuscular process controlling balance; ISS:BHF-UCL.::GO:0060999; P:positive regulation of dendritic spine development; IDA:UniProtKB.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:0006461; P:protein complex assembly; IDA:BHF-UCL.::GO:0035418; P:protein localization to synapse; ISS:BHF-UCL.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.::GO:0060074; P:synapse maturation; IDA:UniProtKB.
178Q6GPJ9    229   GRB2B_XENLA Growth factor receptor-bound prot...540.21     37.7     35     54GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
179Q7ZYG4    214   OSTF1_XENLA Osteoclast-stimulating factor 1 O...530.033     40     34     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
180Q9UKS6    424   PACN3_HUMAN Protein kinase C and casein kinas...573.2     34.3     25     49GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; ISS:UniProtKB.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IMP:BHF-UCL.
181Q6NRL2    550   SNX33_XENLA Sorting nexin-33 OS=Xenopus laevi...830.033     40.8     28     57
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
GO:0007154; P:cell communication; IEA:InterPro.
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