UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YHR112C

Length:

378

Number of sequences:

5887

Description:

YHR112C YHR112C SGDID:S000001154, Chr VIII from 335663-334527, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P38716	378	YHR2_YEAST Uncharacterized trans-sulfuration ...	378	0	785	100	100	GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
									GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
2	O42851	398	YFHE_SCHPO Uncharacterized trans-sulfuration ...	387	3e-95	296	44	59
									GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
3	O05394	379	MCCB_BACSU Cystathionine gamma-lyase OS=Bacil...	343	2e-42	157	33	52
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0047982; F:homocysteine desulfhydrase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
4	P0C2T9	380	METC_LACLC Cystathionine beta-lyase OS=Lactoc...	400	2e-41	155	32	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
5	Q55DV9	387	CGL_DICDI Cystathionine gamma-lyase OS=Dictyo...	391	6e-41	153	31	47	GO:0005737; C:cytoplasm; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.
									GO:0004123; F:cystathionine gamma-lyase activity; ISS:dictyBase.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
6	A2RM21	380	METC_LACLM Cystathionine beta-lyase OS=Lactoc...	400	4e-40	151	31	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
7	P0A4K2	380	METC_LACLA Cystathionine beta-lyase OS=lactis...	400	4e-40	151	31	50	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
8	P53780	464	METC_ARATH Cystathionine beta-lyase, chloropl...	398	6e-40	152	30	49	GO:0009570; C:chloroplast stroma; IDA:TAIR.
									GO:0004121; F:cystathionine beta-lyase activity; IMP:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; TAS:TAIR.
9	O31632	390	METC_BACSU Cystathionine beta-lyase metC OS=B...	397	4e-39	149	30	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
10	O31631	373	METI_BACSU Cystathionine gamma-synthase/O-ace...	389	6e-39	148	30	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
11	P66875	388	METB_MYCTU Cystathionine gamma-synthase OS=My...	391	3e-38	146	30	49	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0004123; F:cystathionine gamma-lyase activity; IDA:MTBBASE.::GO:0003962; F:cystathionine gamma-synthase activity; IDA:MTBBASE.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:MTBBASE.::GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IMP:MTBBASE.
12	P66876	388	METB_MYCBO Cystathionine gamma-synthase OS=My...	391	3e-38	146	30	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
13	Q1M0P5	380	METB_HELPX Cystathionine gamma-synthase OS=He...	395	2e-36	141	30	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
14	P00935	386	METB_ECOLI Cystathionine gamma-synthase OS=Es...	398	3e-36	140	30	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IDA:EcoCyc.::GO:0042802; F:identical protein binding; IPI:EcoCyc.::GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
									GO:0009086; P:methionine biosynthetic process; IMP:EcoCyc.
15	P56069	380	METB_HELPY Cystathionine gamma-synthase OS=py...	395	1e-35	139	29	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
16	P46807	388	METB_MYCLE Cystathionine gamma-synthase OS=My...	394	1e-35	139	30	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
17	Q19QT7	405	CGL_PIG Cystathionine gamma-lyase OS=Sus scro...	380	1e-34	136	32	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
18	Q60HG7	405	CGL_MACFA Cystathionine gamma-lyase OS=Macaca...	398	9e-34	134	32	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
19	Q83A83	387	METC_COXBU Cystathionine beta-lyase OS=Coxiel...	394	2e-33	132	29	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
20	Q9ZMW7	380	METB_HELPJ Cystathionine gamma-synthase OS=He...	395	3e-33	132	29	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
21	P31373	394	CYS3_YEAST Cystathionine gamma-lyase OS=Sacch...	400	7e-32	128	30	49	GO:0005737; C:cytoplasm; IDA:SGD.
									GO:0004123; F:cystathionine gamma-lyase activity; IDA:SGD.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:SGD.::GO:0019346; P:transsulfuration; IMP:SGD.
22	P18757	398	CGL_RAT Cystathionine gamma-lyase OS=Rattus n...	380	1e-31	127	31	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004121; F:cystathionine beta-lyase activity; IDA:RGD.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:RGD.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.::GO:0019346; P:transsulfuration; TAS:RGD.
23	Q8VCN5	398	CGL_MOUSE Cystathionine gamma-lyase OS=Mus mu...	380	3e-31	126	30	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IDA:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0044524; P:protein sulfhydration; IDA:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
24	P32929	405	CGL_HUMAN Cystathionine gamma-lyase OS=Homo s...	398	1e-30	125	33	47	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; IDA:UniProtKB.::GO:0047982; F:homocysteine desulfhydrase activity; TAS:Reactome.::GO:0080146; F:L-cysteine desulfhydrase activity; TAS:Reactome.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IMP:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
									GO:0019344; P:cysteine biosynthetic process; IDA:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; IDA:UniProtKB.::GO:0051289; P:protein homotetramerization; IPI:UniProtKB.::GO:0044524; P:protein sulfhydration; IMP:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; IDA:UniProtKB.::GO:0000098; P:sulfur amino acid catabolic process; TAS:Reactome.::GO:0019346; P:transsulfuration; TAS:Reactome.
25	O94350	390	CBL_SCHPO Cystathionine beta-lyase OS=Schizos...	399	2e-29	120	27	46	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005777; C:peroxisome; ISS:PomBase.
									GO:0004121; F:cystathionine beta-lyase activity; ISS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IC:PomBase.
26	Q58DW2	405	CGL_BOVIN Cystathionine gamma-lyase OS=Bos ta...	382	3e-29	120	30	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
									GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
27	P13254	398	MEGL_PSEPU Methionine gamma-lyase OS=Pseudomo...	393	1e-28	119	26	47
									GO:0018826; F:methionine gamma-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
28	P55217	563	METB_ARATH Cystathionine gamma-synthase, chlo...	398	1e-28	120	27	45	GO:0009570; C:chloroplast stroma; IDA:TAIR.
									GO:0003962; F:cystathionine gamma-synthase activity; IDA:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IMP:TAIR.::GO:0001887; P:selenium compound metabolic process; IDA:TAIR.
29	P55216	392	CGL2_CAEEL Putative cystathionine gamma-lyase...	399	2e-27	115	29	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
30	Q59829	392	CYSA_STRCO Putative cystathionine gamma-lyase...	334	9e-27	113	28	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
31	P44502	369	METB_HAEIN Cystathionine gamma-synthase OS=Ha...	386	2e-25	108	25	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.

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