| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
91 | Q7VQH2 | 610 | CYSJ_BLOFL Sulfite reductase [NADPH] flavopro... | 638 | 3e-50 | 189 | 26 | 44 | | | | | | | | | | | GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004783; F:sulfite reductase (NADPH) activity; IEA:EC. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0000103; P:sulfate assimilation; IEA:InterPro.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 92 | A9LZ73 | 604 | CYSJ_NEIM0 Sulfite reductase [NADPH] flavopro... | 637 | 4e-50 | 189 | 29 | 45 | | | | | | | | | | | GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004783; F:sulfite reductase (NADPH) activity; IEA:EC. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0000103; P:sulfate assimilation; IEA:InterPro.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 93 | Q9JS45 | 604 | CYSJ_NEIMB Sulfite reductase [NADPH] flavopro... | 643 | 7e-50 | 188 | 27 | 42 | | | | | | | | | | | GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004783; F:sulfite reductase (NADPH) activity; IEA:EC. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0000103; P:sulfate assimilation; IEA:InterPro.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 94 | P29477 | 1144 | NOS2_MOUSE Nitric oxide synthase, inducible O... | 653 | 3e-49 | 190 | 27 | 45 | GO:0030863; C:cortical cytoskeleton; IDA:MGI.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. | | | | | | | | | | GO:0034618; F:arginine binding; IDA:BHF-UCL.::GO:0005516; F:calmodulin binding; TAS:UniProtKB.::GO:0050660; F:flavin adenine dinucleotide binding; IDA:BHF-UCL.::GO:0010181; F:FMN binding; IDA:BHF-UCL.::GO:0020037; F:heme binding; IDA:BHF-UCL.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.::GO:0034617; F:tetrahydrobiopterin binding; IDA:BHF-UCL. | | | | | | | | | | GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.::GO:0071346; P:cellular response to interferon-gamma; IDA:MGI.::GO:0071222; P:cellular response to lipopolysaccharide; IDA:MGI.::GO:0042742; P:defense response to bacterium; IMP:MGI.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0010629; P:negative regulation of gene expression; IGI:UniProtKB.::GO:0042177; P:negative regulation of protein catabolic process; IDA:BHF-UCL.::GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.::GO:0018119; P:peptidyl-cysteine S-nitrosylation; IDA:UniProtKB.::GO:0042127; P:regulation of cell proliferation; IGI:MGI.::GO:0001666; P:response to hypoxia; IDA:MGI.::GO:0006801; P:superoxide metabolic process; IMP:MGI. | 95 | O08336 | 1054 | CYPE_BACSU Probable bifunctional P-450/NADPH-... | 635 | 5e-49 | 189 | 26 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:EC. | | | | | | | | | | GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 96 | O62699 | 1154 | NOS2_CANFA Nitric oxide synthase, inducible O... | 652 | 3e-48 | 187 | 27 | 44 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0042742; P:defense response to bacterium; ISS:UniProtKB.::GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.::GO:0018119; P:peptidyl-cysteine S-nitrosylation; ISS:UniProtKB.::GO:0006801; P:superoxide metabolic process; ISS:UniProtKB. | 97 | P70313 | 1202 | NOS3_MOUSE Nitric oxide synthase, endothelial... | 696 | 6e-47 | 183 | 26 | 43 | GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IMP:MGI. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0001974; P:blood vessel remodeling; IMP:BHF-UCL.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IMP:MGI.::GO:0030324; P:lung development; IMP:MGI.::GO:0051926; P:negative regulation of calcium ion transport; IMP:MGI.::GO:0051346; P:negative regulation of hydrolase activity; IMP:MGI.::GO:0014740; P:negative regulation of muscle hyperplasia; IMP:BHF-UCL.::GO:0043267; P:negative regulation of potassium ion transport; IMP:MGI.::GO:0006809; P:nitric oxide biosynthetic process; IMP:MGI.::GO:0001542; P:ovulation from ovarian follicle; IMP:MGI.::GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL.::GO:0050880; P:regulation of blood vessel size; IMP:BHF-UCL.::GO:0002028; P:regulation of sodium ion transport; IMP:MGI.::GO:0014806; P:smooth muscle hyperplasia; IMP:BHF-UCL. | 98 | P35228 | 1153 | NOS2_HUMAN Nitric oxide synthase, inducible O... | 656 | 6e-47 | 183 | 28 | 45 | GO:0005829; C:cytosol; IMP:BHF-UCL.::GO:0005634; C:nucleus; ISS:BHF-UCL.::GO:0005777; C:peroxisome; IDA:UniProtKB. | | | | | | | | | | GO:0034618; F:arginine binding; ISS:BHF-UCL.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; ISS:BHF-UCL.::GO:0010181; F:FMN binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; ISS:BHF-UCL.::GO:0050661; F:NADP binding; TAS:BHF-UCL.::GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.::GO:0034617; F:tetrahydrobiopterin binding; ISS:BHF-UCL. | | | | | | | | | | GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050829; P:defense response to Gram-negative bacterium; NAS:BHF-UCL.::GO:0002227; P:innate immune response in mucosa; NAS:BHF-UCL.::GO:0010629; P:negative regulation of gene expression; IGI:UniProtKB.::GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.::GO:0018119; P:peptidyl-cysteine S-nitrosylation; ISS:UniProtKB.::GO:0051712; P:positive regulation of killing of cells of other organism; IMP:BHF-UCL.::GO:0001912; P:positive regulation of leukocyte mediated cytotoxicity; TAS:BHF-UCL.::GO:0043457; P:regulation of cellular respiration; TAS:BHF-UCL.::GO:0050796; P:regulation of insulin secretion; IMP:BHF-UCL.::GO:0006801; P:superoxide metabolic process; ISS:UniProtKB. | 99 | Q62600 | 1202 | NOS3_RAT Nitric oxide synthase, endothelial O... | 696 | 7e-47 | 183 | 26 | 43 | GO:0045177; C:apical part of cell; IDA:RGD.::GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005730; C:nucleolus; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0012506; C:vesicle membrane; IDA:RGD. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0051879; F:Hsp90 protein binding; IDA:RGD.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IDA:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0034605; P:cellular response to heat; IEP:RGD.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IMP:RGD.::GO:0007565; P:female pregnancy; IEP:RGD.::GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0006809; P:nitric oxide biosynthetic process; IMP:RGD.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0014823; P:response to activity; IEP:RGD.::GO:0043200; P:response to amino acid stimulus; IEP:RGD.::GO:0034097; P:response to cytokine stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032355; P:response to estradiol stimulus; IDA:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0055093; P:response to hyperoxia; IEP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0010288; P:response to lead ion; IEP:RGD.::GO:0055094; P:response to lipoprotein stimulus; IEP:RGD.::GO:0009612; P:response to mechanical stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD. | 100 | P14779 | 1049 | CPXB_BACME Bifunctional P-450/NADPH-P450 redu... | 649 | 2e-46 | 181 | 27 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:EC. | | | | | | | | | | GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 101 | P29473 | 1205 | NOS3_BOVIN Nitric oxide synthase, endothelial... | 696 | 3e-46 | 181 | 27 | 43 | GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:BHF-UCL. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0006916; P:anti-apoptosis; IMP:BHF-UCL.::GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.::GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0007005; P:mitochondrion organization; IMP:BHF-UCL.::GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.::GO:0031284; P:positive regulation of guanylate cyclase activity; IMP:BHF-UCL. | 102 | Q94IN5 | 1803 | PNO_EUGGR Pyruvate dehydrogenase [NADP(+)], m... | 638 | 1e-45 | 180 | 27 | 45 | GO:0005739; C:mitochondrion; IDA:UniProtKB. | | | | | | | | | | GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0050444; F:aquacobalamin reductase (NADPH) activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050243; F:pyruvate dehydrogenase (NADP+) activity; IEA:EC.::GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro. | | | | | | | | | | GO:0045333; P:cellular respiration; IDA:UniProtKB.::GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0006090; P:pyruvate metabolic process; IDA:UniProtKB.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 103 | P29474 | 1203 | NOS3_HUMAN Nitric oxide synthase, endothelial... | 702 | 1e-44 | 176 | 27 | 42 | GO:0005901; C:caveola; IDA:BHF-UCL.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.::GO:0000139; C:Golgi membrane; TAS:Reactome. | | | | | | | | | | GO:0003785; F:actin monomer binding; IPI:BHF-UCL.::GO:0034618; F:arginine binding; IDA:BHF-UCL.::GO:0046870; F:cadmium ion binding; NAS:BHF-UCL.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; NAS:BHF-UCL.::GO:0010181; F:FMN binding; NAS:BHF-UCL.::GO:0020037; F:heme binding; IDA:BHF-UCL.::GO:0050661; F:NADP binding; NAS:BHF-UCL.::GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL.::GO:0034617; F:tetrahydrobiopterin binding; IDA:BHF-UCL. | | | | | | | | | | GO:0006916; P:anti-apoptosis; ISS:BHF-UCL.::GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0001974; P:blood vessel remodeling; ISS:BHF-UCL.::GO:0043542; P:endothelial cell migration; IMP:BHF-UCL.::GO:0007005; P:mitochondrion organization; ISS:BHF-UCL.::GO:0014740; P:negative regulation of muscle hyperplasia; ISS:BHF-UCL.::GO:0010544; P:negative regulation of platelet activation; NAS:BHF-UCL.::GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.::GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL.::GO:0031284; P:positive regulation of guanylate cyclase activity; IMP:BHF-UCL.::GO:0045909; P:positive regulation of vasodilation; NAS:BHF-UCL.::GO:0050880; P:regulation of blood vessel size; ISS:BHF-UCL.::GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.::GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IMP:BHF-UCL.::GO:0034405; P:response to fluid shear stress; IEP:BHF-UCL.::GO:0009408; P:response to heat; NAS:BHF-UCL.::GO:0014806; P:smooth muscle hyperplasia; ISS:BHF-UCL. | 104 | Q27995 | 1156 | NOS2_BOVIN Nitric oxide synthase, inducible O... | 650 | 1e-44 | 176 | 27 | 43 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.::GO:0018119; P:peptidyl-cysteine S-nitrosylation; ISS:UniProtKB. | 105 | Q6BR77 | 603 | TAH18_DEBHA Probable NADPH reductase TAH18 OS... | 658 | 5e-44 | 171 | 26 | 43 | | | | | | | | | | | GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 106 | O54705 | 1149 | NOS2_CAVPO Nitric oxide synthase, inducible O... | 651 | 2e-43 | 172 | 27 | 44 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0042742; P:defense response to bacterium; ISS:UniProtKB.::GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.::GO:0018119; P:peptidyl-cysteine S-nitrosylation; ISS:UniProtKB.::GO:0006801; P:superoxide metabolic process; ISS:UniProtKB. | 107 | Q28969 | 1205 | NOS3_PIG Nitric oxide synthase, endothelial O... | 697 | 3e-43 | 172 | 26 | 42 | GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro. | 108 | Q65T53 | 597 | CYSJ_MANSM Sulfite reductase [NADPH] flavopro... | 171 | 0.000000003 | 63.9 | 29 | 49 | | | | | | | | | | | GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004783; F:sulfite reductase (NADPH) activity; IEA:EC. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0000103; P:sulfate assimilation; IEA:InterPro.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 109 | O19132 | 1435 | NOS1_RABIT Nitric oxide synthase, brain OS=Or... | 711 | 6e-43 | 171 | 26 | 41 | GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro. | 110 | P29475 | 1434 | NOS1_HUMAN Nitric oxide synthase, brain OS=Ho... | 712 | 8e-43 | 171 | 26 | 41 | GO:0005856; C:cytoskeleton; ISS:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.::GO:0001917; C:photoreceptor inner segment; ISS:BHF-UCL.::GO:0042383; C:sarcolemma; IDA:BHF-UCL.::GO:0016529; C:sarcoplasmic reticulum; IDA:BHF-UCL. | | | | | | | | | | GO:0034618; F:arginine binding; TAS:BHF-UCL.::GO:0046870; F:cadmium ion binding; ISS:BHF-UCL.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; ISS:BHF-UCL.::GO:0010181; F:FMN binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; ISS:BHF-UCL.::GO:0050661; F:NADP binding; ISS:BHF-UCL.::GO:0004517; F:nitric-oxide synthase activity; ISS:BHF-UCL.::GO:0034617; F:tetrahydrobiopterin binding; NAS:BHF-UCL. | | | | | | | | | | GO:0006527; P:arginine catabolic process; IC:BHF-UCL.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0033555; P:multicellular organismal response to stress; IMP:BHF-UCL.::GO:0007520; P:myoblast fusion; TAS:BHF-UCL.::GO:0010523; P:negative regulation of calcium ion transport into cytosol; TAS:BHF-UCL.::GO:0042136; P:neurotransmitter biosynthetic process; TAS:BHF-UCL.::GO:0006809; P:nitric oxide biosynthetic process; ISS:BHF-UCL.::GO:0045909; P:positive regulation of vasodilation; IDA:BHF-UCL.::GO:0055117; P:regulation of cardiac muscle contraction; TAS:BHF-UCL.::GO:0009408; P:response to heat; IDA:BHF-UCL.::GO:0001666; P:response to hypoxia; IEP:BHF-UCL. | 111 | Q26240 | 1174 | NOS_RHOPR Nitric oxide synthase, salivary gla... | 696 | 5e-42 | 168 | 26 | 41 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro. | 112 | P29476 | 1429 | NOS1_RAT Nitric oxide synthase, brain OS=Ratt... | 712 | 8e-42 | 167 | 25 | 41 | GO:0042582; C:azurophil granule; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005741; C:mitochondrial outer membrane; IDA:RGD.::GO:0031965; C:nuclear membrane; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0001917; C:photoreceptor inner segment; IDA:BHF-UCL.::GO:0014069; C:postsynaptic density; IDA:RGD.::GO:0042383; C:sarcolemma; IDA:BHF-UCL.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0012506; C:vesicle membrane; IDA:RGD. | | | | | | | | | | GO:0016597; F:amino acid binding; TAS:RGD.::GO:0046870; F:cadmium ion binding; IDA:BHF-UCL.::GO:0005516; F:calmodulin binding; IDA:RGD.::GO:0019899; F:enzyme binding; IPI:RGD.::GO:0050660; F:flavin adenine dinucleotide binding; IDA:BHF-UCL.::GO:0010181; F:FMN binding; IDA:BHF-UCL.::GO:0020037; F:heme binding; IDA:BHF-UCL.::GO:0050661; F:NADP binding; IDA:BHF-UCL.::GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL.::GO:0042803; F:protein homodimerization activity; IDA:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0006527; P:arginine catabolic process; IDA:BHF-UCL.::GO:0007565; P:female pregnancy; IEP:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0045776; P:negative regulation of blood pressure; IMP:RGD.::GO:0045822; P:negative regulation of heart contraction; IMP:RGD.::GO:0046676; P:negative regulation of insulin secretion; IMP:RGD.::GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.::GO:0045909; P:positive regulation of vasodilation; IMP:RGD.::GO:0051930; P:regulation of sensory perception of pain; IMP:RGD.::GO:0014823; P:response to activity; IEP:RGD.::GO:0043627; P:response to estrogen stimulus; IDA:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0009408; P:response to heat; IEP:RGD.::GO:0001666; P:response to hypoxia; IEP:BHF-UCL.::GO:0010288; P:response to lead ion; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0035094; P:response to nicotine; IEP:RGD.::GO:0071731; P:response to nitric oxide; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IMP:RGD.::GO:0033197; P:response to vitamin E; IEP:RGD. | 113 | Q9Z0J4 | 1429 | NOS1_MOUSE Nitric oxide synthase, brain OS=Mu... | 712 | 3e-41 | 166 | 25 | 41 | GO:0005856; C:cytoskeleton; IDA:BHF-UCL.::GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.::GO:0042383; C:sarcolemma; IDA:BHF-UCL.::GO:0045202; C:synapse; IDA:MGI. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0071363; P:cellular response to growth factor stimulus; IMP:BHF-UCL.::GO:0042738; P:exogenous drug catabolic process; IMP:MGI.::GO:0051926; P:negative regulation of calcium ion transport; IMP:MGI.::GO:0051346; P:negative regulation of hydrolase activity; IMP:MGI.::GO:0043267; P:negative regulation of potassium ion transport; IMP:MGI.::GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.::GO:0006809; P:nitric oxide biosynthetic process; IDA:BHF-UCL.::GO:0018119; P:peptidyl-cysteine S-nitrosylation; IDA:MGI.::GO:0035066; P:positive regulation of histone acetylation; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0002028; P:regulation of sodium ion transport; IMP:MGI.::GO:0006941; P:striated muscle contraction; IMP:MGI. | 114 | Q498R1 | 700 | MTRR_RAT Methionine synthase reductase OS=Rat... | 732 | 6e-41 | 162 | 27 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0030586; F:[methionine synthase reductase activity; IEA:EC.::GO:0050660; F:flavin adenine dinucleotide binding; ISS:UniProtKB.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.] | 115 | Q9TUX8 | 1205 | NOS3_CANFA Nitric oxide synthase, endothelial... | 697 | 2e-40 | 162 | 26 | 43 | GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro. | 116 | Q968X7 | 1934 | PNO_CRYPV Pyruvate dehydrogenase [NADP(+)] OS... | 679 | 2e-40 | 163 | 24 | 45 | GO:0005739; C:mitochondrion; ISS:UniProtKB. | | | | | | | | | | GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050243; F:pyruvate dehydrogenase (NADP+) activity; IEA:EC.::GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro. | | | | | | | | | | GO:0045333; P:cellular respiration; ISS:UniProtKB.::GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0006090; P:pyruvate metabolic process; ISS:UniProtKB.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 117 | Q4JIJ2 | 695 | MTRR_BOVIN Methionine synthase reductase OS=B... | 725 | 4e-37 | 151 | 26 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0030586; F:[methionine synthase reductase activity; IEA:EC.::GO:0050660; F:flavin adenine dinucleotide binding; ISS:UniProtKB.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.] | 118 | O61608 | 1247 | NOS_ANOST Nitric oxide synthase OS=Anopheles ... | 68 | 0.005 | 43.9 | 34 | 57 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro. | 119 | Q9Y8G7 | 1066 | C505_FUSOX Bifunctional P-450:NADPH-P450 redu... | 651 | 8e-37 | 151 | 25 | 43 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:EC. | | | | | | | | | | GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 120 | B1B557 | 1097 | NOSL_BOMMO Nitric oxide synthase-like protein... | 73 | 0.00008 | 49.7 | 36 | 56 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0010181; F:FMN binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004517; F:nitric-oxide synthase activity; IEA:EC. | | | | | | | | | | GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro. | 121 | P0CP12 | 617 | TAH18_CRYNJ Probable NADPH reductase TAH18 OS... | 669 | 2e-36 | 148 | 23 | 43 | | | | | | | | | | | GO:0010181; F:FMN binding; IEA:InterPro.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | |
