UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YHR037W

Length:

575

Number of sequences:

5887

Description:

YHR037W PUT2 SGDID:S000001079, Chr VIII from 181977-183704, Genome Release 64-1-1, Verified ORF, "Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	Q9K9B2	515	ROCA1_BACHD 1-pyrroline-5-carboxylate dehydro...	504	8e-82	271	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
32	Q65NN2	516	ROCA_BACLD 1-pyrroline-5-carboxylate dehydrog...	505	2e-80	268	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
33	A4IJP9	515	ROCA_GEOTN 1-pyrroline-5-carboxylate dehydrog...	546	6e-79	264	34	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
34	Q5L3K8	515	ROCA_GEOKA 1-pyrroline-5-carboxylate dehydrog...	541	1e-78	263	34	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
35	C5D4J5	515	ROCA_GEOSW 1-pyrroline-5-carboxylate dehydrog...	543	3e-77	259	34	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
36	A8F9T1	515	ROCA_BACP2 1-pyrroline-5-carboxylate dehydrog...	506	7e-77	258	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
37	Q9K5Z5	515	ROCA2_BACHD 1-pyrroline-5-carboxylate dehydro...	502	3e-75	254	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
38	A7GKJ4	515	ROCA_BACCN 1-pyrroline-5-carboxylate dehydrog...	503	5e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
39	Q6HP91	515	ROCA_BACHK 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
40	Q63GS0	515	ROCA_BACCZ 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
41	B9J1L9	515	ROCA_BACCQ 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
42	B7HSW8	515	ROCA_BACC7 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
43	C1EV77	515	ROCA_BACC3 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
44	B7JM99	515	ROCA_BACC0 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
45	Q81ZF8	515	ROCA_BACAN 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
46	A0R909	515	ROCA_BACAH 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
47	C3L546	515	ROCA_BACAC 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
48	C3PBP4	515	ROCA_BACAA 1-pyrroline-5-carboxylate dehydrog...	506	9e-75	253	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
49	A9VRG6	515	ROCA_BACWK 1-pyrroline-5-carboxylate dehydrog...	505	1e-74	253	34	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
50	P62028	515	ROCA_BACC1 1-pyrroline-5-carboxylate dehydrog...	506	2e-74	252	35	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
51	Q81IP0	515	ROCA_BACCR 1-pyrroline-5-carboxylate dehydrog...	506	2e-74	252	35	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
52	B7H4V1	515	ROCA_BACC4 1-pyrroline-5-carboxylate dehydrog...	506	2e-74	252	35	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
53	B7IUW8	515	ROCA_BACC2 1-pyrroline-5-carboxylate dehydrog...	506	2e-74	252	35	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
54	P39634	515	ROCA_BACSU 1-pyrroline-5-carboxylate dehydrog...	505	2e-74	252	35	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
55	B7GFV3	515	ROCA_ANOFW 1-pyrroline-5-carboxylate dehydrog...	505	5e-73	248	34	51
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
56	P09546	1320	PUTA_ECOLI Bifunctional protein putA OS=Esche...	541	8e-49	187	30	46	GO:0009898; C:internal side of plasma membrane; IDA:EcoCyc.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IDA:EcoCyc.::GO:0000986; F:bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc.::GO:0001141; F:bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:EcoCyc.::GO:0050660; F:flavin adenine dinucleotide binding; IDA:EcoCyc.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004657; F:proline dehydrogenase activity; IDA:EcoCyc.
									GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.::GO:0006561; P:proline biosynthetic process; IEA:InterPro.::GO:0010133; P:proline catabolic process to glutamate; IMP:EcoCyc.
57	P10503	1320	PUTA_SALTY Bifunctional protein putA OS=Salmo...	507	4e-47	182	30	46
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004657; F:proline dehydrogenase activity; IEA:EC.
									GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.::GO:0006561; P:proline biosynthetic process; IEA:InterPro.::GO:0006562; P:proline catabolic process; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
58	O52485	1312	PUTA_ENTAE Bifunctional protein putA OS=Enter...	490	7e-47	182	30	46
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.::GO:0004657; F:proline dehydrogenase activity; IEA:EC.
									GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.::GO:0006561; P:proline biosynthetic process; IEA:InterPro.::GO:0006562; P:proline catabolic process; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
59	P47895	512	AL1A3_HUMAN Aldehyde dehydrogenase family 1 m...	495	9e-43	164	30	47	GO:0005737; C:cytoplasm; IDA:UniProtKB.
									GO:0004030; F:aldehyde dehydrogenase [NAD(P)+ activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
									GO:0042574; P:retinal metabolic process; IDA:UniProtKB.]
60	P00352	501	AL1A1_HUMAN Retinal dehydrogenase 1 OS=Homo s...	499	2e-42	164	30	47	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0004029; F:aldehyde dehydrogenase (NAD) activity; EXP:Reactome.::GO:0005497; F:androgen binding; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; TAS:UniProtKB.::GO:0001758; F:retinal dehydrogenase activity; IEA:EC.
									GO:0006081; P:cellular aldehyde metabolic process; TAS:ProtInc.::GO:0006069; P:ethanol oxidation; TAS:Reactome.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
61	Q8HYE4	501	AL1A1_MACFA Retinal dehydrogenase 1 OS=Macaca...	503	6e-42	162	30	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0001758; F:retinal dehydrogenase activity; IEA:EC.

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