UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YHR037W

Length:

575

Number of sequences:

5887

Description:

YHR037W PUT2 SGDID:S000001079, Chr VIII from 181977-183704, Genome Release 64-1-1, Verified ORF, "Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P07275	575	PUT2_YEAST Delta-1-pyrroline-5-carboxylate de...	575	0	1197	100	100	GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005759; C:mitochondrial matrix; IDA:SGD.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IDA:SGD.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006537; P:glutamate biosynthetic process; IDA:SGD.::GO:0006561; P:proline biosynthetic process; IEA:InterPro.::GO:0010133; P:proline catabolic process to glutamate; IMP:SGD.
2	Q9P8I0	572	PUT2_EMENI Delta-1-pyrroline-5-carboxylate de...	579	0	617	54	68	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
3	O74766	548	PUT2_SCHPO Probable delta-1-pyrroline-5-carbo...	565	0	557	51	66	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005759; C:mitochondrial matrix; IEA:InterPro.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; ISS:PomBase.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006537; P:glutamate biosynthetic process; ISS:PomBase.::GO:0006561; P:proline biosynthetic process; ISS:PomBase.
4	Q54RA2	558	AL4A1_DICDI Delta-1-pyrroline-5-carboxylate d...	526	3e-176	517	50	67	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
5	P78568	546	PUT2_AGABI Delta-1-pyrroline-5-carboxylate de...	529	1e-173	510	50	66	GO:0005759; C:mitochondrial matrix; IEA:InterPro.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
6	Q7SY23	556	AL4A1_DANRE Delta-1-pyrroline-5-carboxylate d...	574	7e-152	455	43	61	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
7	A7YWE4	563	AL4A1_BOVIN Delta-1-pyrroline-5-carboxylate d...	575	9e-150	449	42	58	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
8	P30038	563	AL4A1_HUMAN Delta-1-pyrroline-5-carboxylate d...	574	1e-147	444	42	59	GO:0005759; C:mitochondrial matrix; TAS:Reactome.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; EXP:Reactome.::GO:0004029; F:aldehyde dehydrogenase (NAD) activity; TAS:ProtInc.::GO:0009055; F:electron carrier activity; TAS:UniProtKB.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.::GO:0006562; P:proline catabolic process; TAS:Reactome.
9	Q8CHT0	562	AL4A1_MOUSE Delta-1-pyrroline-5-carboxylate d...	543	2e-147	443	43	61	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
10	P0C2X9	563	AL4A1_RAT Delta-1-pyrroline-5-carboxylate deh...	548	6e-142	429	42	60	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
11	Q8ERF4	515	ROCA_OCEIH 1-pyrroline-5-carboxylate dehydrog...	505	3e-87	286	36	55
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
12	Q8CN04	514	ROCA_STAES 1-pyrroline-5-carboxylate dehydrog...	539	4e-85	280	34	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
13	Q5HL59	514	ROCA_STAEQ 1-pyrroline-5-carboxylate dehydrog...	539	4e-85	280	34	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
14	Q8NUR2	514	ROCA_STAAW 1-pyrroline-5-carboxylate dehydrog...	537	7e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
15	A8Z3F5	514	ROCA_STAAT 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
16	Q6GDP4	514	ROCA_STAAR 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
17	P99076	514	ROCA_STAAN 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
18	P63939	514	ROCA_STAAM 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
19	A6QK44	514	ROCA_STAAE 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
20	Q5HCZ6	514	ROCA_STAAC 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
21	Q2YWA6	514	ROCA_STAAB 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
22	A5IVY0	514	ROCA_STAA9 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
23	Q2FV67	514	ROCA_STAA8 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
24	Q2FDV3	514	ROCA_STAA3 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
25	A6U4T5	514	ROCA_STAA2 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
26	A7X6R7	514	ROCA_STAA1 1-pyrroline-5-carboxylate dehydrog...	537	8e-85	280	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
27	Q6G6C0	514	ROCA_STAAS 1-pyrroline-5-carboxylate dehydrog...	537	7e-84	277	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
28	P94391	515	ROCA2_BACSU 1-pyrroline-5-carboxylate dehydro...	505	4e-83	275	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
29	Q4A0E7	514	ROCA_STAS1 1-pyrroline-5-carboxylate dehydrog...	540	5e-83	275	34	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
30	Q4L966	514	ROCA_STAHJ 1-pyrroline-5-carboxylate dehydrog...	541	5e-82	272	34	52
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.
31	Q9K9B2	515	ROCA1_BACHD 1-pyrroline-5-carboxylate dehydro...	504	8e-82	271	35	53
									GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:EC.::GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
									GO:0006561; P:proline biosynthetic process; IEA:InterPro.

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