Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHR016C
Length:
468
Number of sequences:
5887
Description:
YHR016C YSC84 SGDID:S000001058, Chr VIII from 138240-136881,138455-138409, Genome Release 64-1-1, reverse complement, Verified ORF, "Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q4R729    692   SH321_MACFA SH3 domain-containing protein 21 ...490.000001     55.1     37     61
92P34109    1109   MYOD_DICDI Myosin ID heavy chain OS=Dictyoste...720.000001     55.1     35     58GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0031252; C:cell leading edge; IDA:dictyBase.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.::GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
93Q8TEC5    729   SH3R2_HUMAN Putative E3 ubiquitin-protein lig...530.1     38.9     38     58
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008157; F:protein phosphatase 1 binding; IDA:UniProtKB.::GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
94Q2KJA1    368   SH3G1_BOVIN Endophilin-A2 OS=Bos taurus (Bovi...560.000001     53.9     41     63GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
95Q60992    868   VAV2_MOUSE Guanine nucleotide exchange factor...620.000001     54.7     42     55GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI.
96Q60631    217   GRB2_MOUSE Growth factor receptor-bound prote...540.00003     48.9     37     61GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0012506; C:vesicle membrane; IDA:MGI.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:MGI.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; IDA:MGI.
GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.::GO:0060670; P:branching involved in embryonic placenta morphogenesis; IMP:MGI.::GO:0030154; P:cell differentiation; IMP:MGI.::GO:0030838; P:positive regulation of actin filament polymerization; IGI:MGI.::GO:0007265; P:Ras protein signal transduction; TAS:MGI.::GO:0043408; P:regulation of MAPK cascade; IGI:MGI.
97P62994    217   GRB2_RAT Growth factor receptor-bound protein...540.00003     48.9     37     61GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:RGD.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0001784; F:phosphotyrosine binding; IPI:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD.
GO:0007568; P:aging; IPI:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0007265; P:Ras protein signal transduction; TAS:RGD.
98Q5R4J7    217   GRB2_PONAB Growth factor receptor-bound prote...540.00003     48.9     37     61GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
99P62993    217   GRB2_HUMAN Growth factor receptor-bound prote...540.00003     48.9     37     61GO:0005829; C:cytosol; TAS:HGNC.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:UniProtKB.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007267; P:cell-cell signaling; TAS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB.::GO:0031623; P:receptor internalization; IMP:BHF-UCL.::GO:0042770; P:signal transduction in response to DNA damage; IMP:BHF-UCL.::GO:0031295; P:T cell costimulation; TAS:Reactome.
100Q3UTJ2    1180   SRBS2_MOUSE Sorbin and SH3 domain-containing ...530.33     37.4     32     57GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
101Q5A895    498   HSE1_CANAL Class E vacuolar protein-sorting m...510.000002     53.9     49     67GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
102P52735    878   VAV2_HUMAN Guanine nucleotide exchange factor...610.2     38.1     38     56GO:0005829; C:cytosol; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
103O75791    330   GRAP2_HUMAN GRB2-related adapter protein 2 OS...550.1     38.5     31     53GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
104P70248    1099   MYO1F_MOUSE Unconventional myosin-If OS=Mus m...540.000002     53.9     44     61GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
105O35413    1196   SRBS2_RAT Sorbin and SH3 domain-containing pr...530.31     37.4     32     57GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD.
GO:0008270; F:zinc ion binding; IEA:InterPro.
106O01498    457   STAM1_CAEEL Signal transducing adapter molecu...640.000003     53.1     39     61GO:0044441; C:cilium part; IDA:UniProtKB.::GO:0005769; C:early endosome; IDA:WormBase.::GO:0033565; C:ESCRT-0 complex; IPI:WormBase.
GO:0008022; F:protein C-terminus binding; IPI:WormBase.::GO:0043130; F:ubiquitin binding; IDA:WormBase.
GO:0008333; P:endosome to lysosome transport; IMP:WormBase.::GO:0048013; P:ephrin receptor signaling pathway; IGI:UniProtKB.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0043409; P:negative regulation of MAPK cascade; IMP:UniProtKB.
107Q6ZMT1    411   STAC2_HUMAN SH3 and cysteine-rich domain-cont...520.000003     52.8     44     62
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
108Q8R1B0    408   STAC2_MOUSE SH3 and cysteine-rich domain-cont...520.000003     52.8     44     62
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
109O94875    1100   SRBS2_HUMAN Sorbin and SH3 domain-containing ...530.19     38.1     34     57GO:0015629; C:actin cytoskeleton; TAS:ProtInc.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0005634; C:nucleus; NAS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; NAS:UniProtKB.
GO:0008093; F:cytoskeletal adaptor activity; TAS:ProtInc.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.::GO:0008307; F:structural constituent of muscle; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
110O88811    523   STAM2_MOUSE Signal transducing adapter molecu...630.000004     52.8     40     59GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
111Q6GPJ9    229   GRB2B_XENLA Growth factor receptor-bound prot...540.00002     48.9     39     61GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
112Q5I0D6    502   NOSTN_RAT Nostrin OS=Rattus norvegicus (Rat)....500.000004     52.8     48     62GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
113Q66II3    229   GRB2_XENTR Growth factor receptor-bound prote...550.00003     48.9     38     60GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
114Q8N157    1196   AHI1_HUMAN Jouberin OS=Homo sapiens (Human). ...900.000004     53.1     34     53GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IDA:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
115Q63767    968   BCAR1_RAT Breast cancer anti-estrogen resista...690.000004     53.1     35     62GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
116P15498    845   VAV_HUMAN Proto-oncogene vav OS=Homo sapiens ...530.000005     52.8     47     58GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.
117Q9Y7Z8    1217   MYO1_SCHPO Myosin-1 OS=Schizosaccharomyces po...510.000006     52.8     45     61GO:0030479; C:actin cortical patch; IDA:PomBase.::GO:0005826; C:actomyosin contractile ring; TAS:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0031097; C:medial cortex; IDA:PomBase.::GO:0045121; C:membrane raft; IDA:PomBase.::GO:0045160; C:myosin I complex; TAS:PomBase.::GO:0005628; C:prospore membrane; IDA:PomBase.::GO:0030427; C:site of polarized growth; IDA:PomBase.
GO:0003779; F:actin binding; NAS:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; TAS:PomBase.
GO:0000147; P:actin cortical patch assembly; IGI:PomBase.::GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0045010; P:actin nucleation; IDA:PomBase.::GO:0030476; P:ascospore wall assembly; IMP:PomBase.::GO:0071937; P:barrier septum assembly involved in cell cycle cytokinesis; IMP:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:PomBase.::GO:0031580; P:membrane raft distribution; IMP:PomBase.::GO:0051127; P:positive regulation of actin nucleation; IMP:PomBase.::GO:0030100; P:regulation of endocytosis; IMP:PomBase.
118Q2KJB5    505   NOSTN_BOVIN Nostrin OS=Bos taurus (Bovine). G...500.000006     52.4     50     60GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
119P97369    339   NCF4_MOUSE Neutrophil cytosol factor 4 OS=Mus...560.000006     51.6     43     63GO:0005737; C:cytoplasm; IDA:MGI.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.
GO:0007154; P:cell communication; IEA:InterPro.
120Q96N96    652   SPT13_HUMAN Spermatogenesis-associated protei...720.000006     52.4     39     53GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0046847; P:filopodium assembly; IMP:UniProtKB.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
121Q8MJ50    214   OSTF1_BOVIN Osteoclast-stimulating factor 1 O...500.000006     50.4     44     62GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
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