Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHR016C
Length:
468
Number of sequences:
5887
Description:
YHR016C YSC84 SGDID:S000001058, Chr VIII from 138240-136881,138455-138409, Genome Release 64-1-1, reverse complement, Verified ORF, "Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
181P13395    2415   SPTCA_DROME Spectrin alpha chain OS=Drosophil...520.00004     50.1     38     65GO:0016323; C:basolateral plasma membrane; IDA:FlyBase.::GO:0005938; C:cell cortex; IDA:FlyBase.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0045169; C:fusome; IDA:FlyBase.::GO:0005794; C:Golgi apparatus; IDA:FlyBase.::GO:0031594; C:neuromuscular junction; IDA:FlyBase.::GO:0045170; C:spectrosome; IDA:FlyBase.
GO:0003779; F:actin binding; IDA:FlyBase.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; IDA:FlyBase.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0016199; P:axon midline choice point recognition; IGI:FlyBase.::GO:0007417; P:central nervous system development; IMP:FlyBase.::GO:0045478; P:fusome organization; TAS:FlyBase.::GO:0030727; P:germarium-derived female germ-line cyst formation; IMP:FlyBase.::GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.::GO:0042062; P:long-term strengthening of neuromuscular junction; IMP:FlyBase.::GO:0048790; P:maintenance of presynaptic active zone structure; IDA:FlyBase.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.::GO:0007308; P:oocyte construction; IMP:FlyBase.::GO:0030707; P:ovarian follicle cell development; TAS:FlyBase.::GO:0007009; P:plasma membrane organization; TAS:FlyBase.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.::GO:0030721; P:spectrosome organization; TAS:FlyBase.
182O70145    525   NCF2_MOUSE Neutrophil cytosol factor 2 OS=Mus...500.022     40.8     34     58GO:0001669; C:acrosomal vesicle; IDA:MGI.
GO:0048365; F:Rac GTPase binding; IPI:MGI.
GO:0042554; P:superoxide anion generation; IDA:MGI.
183Q9NYB9    513   ABI2_HUMAN Abl interactor 2 OS=Homo sapiens (...520.00005     49.3     38     69GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:BHF-UCL.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.
GO:0008093; F:cytoskeletal adaptor activity; TAS:UniProtKB.::GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0019900; F:kinase binding; NAS:UniProtKB.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IPI:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0008154; P:actin polymerization or depolymerization; NAS:UniProtKB.::GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.
184P46109    303   CRKL_HUMAN Crk-like protein OS=Homo sapiens (...401.6     34.7     33     63GO:0005829; C:cytosol; TAS:Reactome.
GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; TAS:ProtInc.
GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.
185Q6WKZ7    506   NOSTN_MOUSE Nostrin OS=Mus musculus (Mouse). ...500.00005     49.3     44     58GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
186O77775    527   NCF2_BOVIN Neutrophil cytosol factor 2 OS=Bos...510.017     41.2     33     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005488; F:binding; IEA:InterPro.
187Q9NHC3    279   CED2_CAEEL Cell death abnormality protein 2 O...570.00005     48.5     39     58GO:0005886; C:plasma membrane; NAS:WormBase.
GO:0032403; F:protein complex binding; IPI:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.::GO:0006915; P:apoptotic process; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0043652; P:engulfment of apoptotic cell; IMP:UniProtKB.::GO:0007165; P:signal transduction; IMP:UniProtKB.
188Q9UKW4    847   VAV3_HUMAN Guanine nucleotide exchange factor...530.00006     49.3     43     57GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0030890; P:positive regulation of B cell proliferation; IMP:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.::GO:0042493; P:response to drug; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
189O13154    448   PACN2_CHICK Protein kinase C and casein kinas...510.00006     48.9     45     69GO:0005829; C:cytosol; ISS:AgBase.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; ISS:AgBase.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; ISS:AgBase.
190P98171    946   RHG04_HUMAN Rho GTPase-activating protein 4 O...520.00006     49.3     37     62GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007010; P:cytoskeleton organization; TAS:ProtInc.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.
191P16333    377   NCK1_HUMAN Cytoplasmic protein NCK1 OS=Homo s...554.6     33.1     33     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0008093; F:cytoskeletal adaptor activity; NAS:UniProtKB.::GO:0005102; F:receptor binding; IPI:UniProtKB.::GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0030838; P:positive regulation of actin filament polymerization; IMP:UniProtKB.::GO:0042102; P:positive regulation of T cell proliferation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0007172; P:signal complex assembly; NAS:UniProtKB.::GO:0042110; P:T cell activation; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
192Q6TGW5    214   OSTF1_DANRE Osteoclast-stimulating factor 1 O...500.00006     47.8     42     62GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
193O75886    525   STAM2_HUMAN Signal transducing adapter molecu...500.00006     48.9     40     64GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0016197; P:endosome transport; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
194Q5ZLR6    764   ARHG6_CHICK Rho guanine nucleotide exchange f...940.00007     49.3     34     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
195Q925Q9    709   SH3K1_RAT SH3 domain-containing kinase-bindin...490.008     42.4     31     61GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; TAS:RGD.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
196P02549    2419   SPTA1_HUMAN Spectrin alpha chain, erythrocyte...520.00008     49.3     44     58GO:0005829; C:cytosol; TAS:Reactome.::GO:0031235; C:intrinsic to internal side of plasma membrane; TAS:BHF-UCL.::GO:0008091; C:spectrin; TAS:ProtInc.::GO:0014731; C:spectrin-associated cytoskeleton; IDA:BHF-UCL.
GO:0051015; F:actin filament binding; TAS:ProtInc.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0007015; P:actin filament organization; TAS:ProtInc.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
197Q8R550    709   SH3K1_MOUSE SH3 domain-containing kinase-bind...490.008     42.4     31     61GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
198Q9UNF0    486   PACN2_HUMAN Protein kinase C and casein kinas...610.00008     48.5     41     62GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005215; F:transporter activity; TAS:ProtInc.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
199O75044    1071   FNBP2_HUMAN SLIT-ROBO Rho GTPase-activating p...920.00008     48.9     29     52GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
200Q14247    550   SRC8_HUMAN Src substrate cortactin OS=Homo sa...550.00008     48.5     40     62GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; TAS:ProtInc.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.::GO:0005625; C:soluble fraction; TAS:ProtInc.
GO:0005515; F:protein binding; IPI:UniProtKB.
201Q96B97    665   SH3K1_HUMAN SH3 domain-containing kinase-bind...490.009     42.4     31     61GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0007267; P:cell-cell signaling; NAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.
202P47941    303   CRKL_MOUSE Crk-like protein OS=Mus musculus (...401.7     34.7     33     63
GO:0005515; F:protein binding; IPI:MGI.
GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.::GO:0001568; P:blood vessel development; IGI:MGI.::GO:0007507; P:heart development; IGI:MGI.::GO:0009887; P:organ morphogenesis; IMP:MGI.::GO:0060017; P:parathyroid gland development; IGI:MGI.::GO:0048538; P:thymus development; IGI:MGI.
203Q5U2U2    303   CRKL_RAT Crk-like protein OS=Rattus norvegicu...401.7     34.7     33     63
204Q6DTM3    1047   AHI1_RAT Jouberin OS=Rattus norvegicus (Rat)....550.00009     48.9     40     58GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; ISS:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
205Q99M51    377   NCK1_MOUSE Cytoplasmic protein NCK1 OS=Mus mu...554.8     33.1     33     51GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; IDA:MGI.
GO:0019904; F:protein domain specific binding; IPI:MGI.
GO:0007015; P:actin filament organization; IMP:MGI.::GO:0016477; P:cell migration; IMP:MGI.::GO:0030032; P:lamellipodium assembly; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
206Q96MF2    364   STAC3_HUMAN SH3 and cysteine-rich domain-cont...510.00009     48.1     41     57
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
207Q14155    803   ARHG7_HUMAN Rho guanine nucleotide exchange f...510.00009     48.5     43     59GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:BHF-UCL.::GO:0043025; C:neuronal cell body; IDA:BHF-UCL.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043547; P:positive regulation of GTPase activity; IDA:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
208P49710    486   HCLS1_MOUSE Hematopoietic lineage cell-specif...510.0001     48.1     41     63GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0032403; F:protein complex binding; IPI:MGI.::GO:0017124; F:SH3 domain binding; IDA:MGI.
GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IMP:UniProtKB.::GO:0009725; P:response to hormone stimulus; IDA:UniProtKB.
209Q8BZ71    360   STAC3_MOUSE SH3 and cysteine-rich domain-cont...510.0001     47.8     41     57
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
210Q9ES28    862   ARHG7_MOUSE Rho guanine nucleotide exchange f...510.0001     48.5     43     59GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
211Q01406    563   SRC8_CHICK Src substrate protein p85 OS=Gallu...600.0001     48.1     37     58GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
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