Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHL039W
Length:
585
Number of sequences:
5887
Description:
YHL039W EFM1 SGDID:S000001031, Chr VIII from 21783-23540, Genome Release 64-1-1, Verified ORF, "Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P38732    585   EFM1_YEAST N-lysine methyltransferase EFM1 OS...5850     1198     100     100GO:0005737; C:cytoplasm; IDA:SGD.
GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0018026; P:peptidyl-lysine monomethylation; IMP:SGD.
2Q08961    583   RKM1_YEAST Ribosomal N-lysine methyltransfera...5237e-41     160     28     44GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0016279; F:protein-lysine N-methyltransferase activity; IMP:SGD.
GO:0018027; P:peptidyl-lysine dimethylation; IDA:SGD.
3O74738    547   YH9D_SCHPO SET domain-containing protein C170...3150.0000000003     66.6     25     42GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0016279; F:protein-lysine N-methyltransferase activity; IMP:PomBase.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:PomBase.::GO:0042254; P:ribosome biogenesis; NAS:PomBase.
4Q9NVD3    440   SETD4_HUMAN SET domain-containing protein 4 O...2680.00000004     59.3     25     38
5P58467    439   SETD4_MOUSE SET domain-containing protein 4 O...2610.0000004     56.2     24     36
6C1FXW2    589   SETD3_DASNO Histone-lysine N-methyltransferas...3540.0000009     55.5     22     41GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q9XI84    482   RBCMT_ARATH Probable ribulose-1,5 bisphosphat...2270.000001     55.1     28     42GO:0009570; C:chloroplast stroma; IDA:TAIR.
GO:0030785; F:[ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity; IEA:EC.]
8B2KI88    594   SETD3_RHIFE Histone-lysine N-methyltransferas...3540.000003     53.9     22     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9P94026    491   RBCMT_TOBAC Ribulose-1,5 bisphosphate carboxy...2640.000006     52.8     27     39GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
GO:0030785; F:[ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity; IEA:EC.]
10A9X1D0    595   SETD3_PAPAN Histone-lysine N-methyltransferas...3540.00001     52     21     41GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
11Q86TU7    594   SETD3_HUMAN Histone-lysine N-methyltransferas...3540.00001     52     21     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
12B7ZUF3    582   SETD3_XENTR Histone-lysine N-methyltransferas...3500.00001     51.6     21     39GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
13B1MTJ4    595   SETD3_CALMO Histone-lysine N-methyltransferas...3540.00001     51.6     21     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14B5FW36    595   SETD3_OTOGA Histone-lysine N-methyltransferas...3540.00002     51.2     21     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15Q91WC0    594   SETD3_MOUSE Histone-lysine N-methyltransferas...3580.00004     50.4     22     41GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16B0VX69    595   SETD3_CALJA Histone-lysine N-methyltransferas...3540.00004     50.1     21     40GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17E2RBS6    588   SETD3_CANFA Histone-lysine N-methyltransferas...3580.00007     49.3     22     41GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18Q5ZML9    593   SETD3_CHICK Histone-lysine N-methyltransferas...3560.0003     47.4     21     38GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
19Q6INM2    455   SETD6_XENLA N-lysine methyltransferase setd6 ...2970.0008     45.8     25     39GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
20A4QNG5    454   SETD6_XENTR N-lysine methyltransferase setd6 ...2930.002     44.3     25     38GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
21Q7SXS7    596   SETD3_DANRE Histone-lysine N-methyltransferas...3500.048     40.4     20     38GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IDA:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
GO:0016049; P:cell growth; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0018027; P:peptidyl-lysine dimethylation; IDA:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; IDA:UniProtKB.::GO:0018023; P:peptidyl-lysine trimethylation; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
22Q43088    489   RBCMT_PEA Ribulose-1,5 bisphosphate carboxyla...3560.097     39.3     23     39GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
GO:0030785; F:[ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity; IEA:EC.]
23Q5ZK17    447   SETD6_CHICK N-lysine methyltransferase SETD6 ...2900.52     37     24     37GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
24O14135    429   SET8_SCHPO SET domain-containing protein 8 OS...1960.74     36.2     20     37GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
25O74405    381   SET11_SCHPO Ribosomal N-lysine methyltransfer...701     35.8     24     53GO:0005829; C:cytosol; IDA:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase.
GO:0016279; F:protein-lysine N-methyltransferase activity; IDA:PomBase.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0042254; P:ribosome biogenesis; TAS:PomBase.
26A8F5A0    674   IF2_THELT Translation initiation factor IF-2 ...1742.1     35     25     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
27C0H8I2    449   SETD6_SALSA N-lysine methyltransferase setd6 ...2022.1     34.7     23     38GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.::GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
28Q9GKK8    1863   BRCA1_PANTR Breast cancer type 1 susceptibili...865.3     33.9     29     45GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.::GO:0008274; C:gamma-tubulin ring complex; NAS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0015631; F:tubulin binding; NAS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; TAS:UniProtKB.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0046600; P:negative regulation of centriole replication; NAS:UniProtKB.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; NAS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; TAS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0006359; P:regulation of transcription from RNA polymerase III promoter; TAS:UniProtKB.
29Q6J6I8    1863   BRCA1_GORGO Breast cancer type 1 susceptibili...865.4     33.9     29     45GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.
30B0TXG8    380   LPXB_FRAP2 Lipid-A-disaccharide synthase OS=F...558.1     32.7     33     62
GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:EC.
GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
31P38398    1863   BRCA1_HUMAN Breast cancer type 1 susceptibili...889.6     33.1     28     47GO:0070531; C:BRCA1-A complex; IDA:UniProtKB.::GO:0031436; C:BRCA1-BARD1 complex; IDA:UniProtKB.::GO:0008274; C:gamma-tubulin ring complex; NAS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:BHF-UCL.::GO:0030529; C:ribonucleoprotein complex; IDA:MGI.::GO:0001726; C:ruffle; IDA:BHF-UCL.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IDA:MGI.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.::GO:0015631; F:tubulin binding; NAS:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0071681; P:cellular response to indole-3-methanol; IDA:UniProtKB.::GO:0007059; P:chromosome segregation; IMP:UniProtKB.::GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; TAS:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IDA:MGI.::GO:0000724; P:double-strand break repair via homologous recombination; IDA:HGNC.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:UniProtKB.::GO:0046600; P:negative regulation of centriole replication; NAS:UniProtKB.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; IMP:UniProtKB.::GO:0051573; P:negative regulation of histone H3-K9 methylation; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0071158; P:positive regulation of cell cycle arrest; IDA:BHF-UCL.::GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.::GO:0051571; P:positive regulation of histone H3-K4 methylation; IDA:BHF-UCL.::GO:2000617; P:positive regulation of histone H3-K9 acetylation; IDA:BHF-UCL.::GO:2000620; P:positive regulation of histone H4-K16 acetylation; IDA:BHF-UCL.::GO:0070512; P:positive regulation of histone H4-K20 methylation; IDA:BHF-UCL.::GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006301; P:postreplication repair; IDA:HGNC.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:2000145; P:regulation of cell motility; IDA:BHF-UCL.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0006359; P:regulation of transcription from RNA polymerase III promoter; TAS:UniProtKB.::GO:0010212; P:response to ionizing radiation; IMP:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:BHF-UCL.
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