UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YHL002W

Length:

452

Number of sequences:

5887

Description:

YHL002W HSE1 SGDID:S000000994, Chr VIII from 102612-103970, Genome Release 64-1-1, Verified ORF, "Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
301	O43307	516	ARHG9_HUMAN Rho guanine nucleotide exchange f...	57	0.0002	47	39	54	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0034220; P:ion transmembrane transport; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.
302	P19174	1290	PLCG1_HUMAN 1-phosphatidylinositol 4,5-bispho...	73	0.0002	47.4	37	51	GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; NAS:UniProtKB.
									GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0045766; P:positive regulation of angiogenesis; IDA:DFLAT.::GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:DFLAT.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
303	Q5I1X5	824	IASPP_MOUSE RelA-associated inhibitor OS=Mus ...	53	0.0003	47.4	43	57	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005515; F:protein binding; IPI:MGI.
									GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0060048; P:cardiac muscle contraction; IMP:MGI.::GO:0003215; P:cardiac right ventricle morphogenesis; IMP:MGI.::GO:0031076; P:embryonic camera-type eye development; IMP:MGI.::GO:0042633; P:hair cycle; IMP:MGI.::GO:0035264; P:multicellular organism growth; IMP:MGI.::GO:0048871; P:multicellular organismal homeostasis; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0003229; P:ventricular cardiac muscle tissue development; IMP:MGI.
304	Q5RDK0	564	ARHG9_PONAB Rho guanine nucleotide exchange f...	57	0.0003	47	39	54	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
305	Q8BZ71	360	STAC3_MOUSE SH3 and cysteine-rich domain-cont...	48	0.0003	46.6	38	58
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
306	Q3UTH8	516	ARHG9_MOUSE Rho guanine nucleotide exchange f...	52	0.0003	46.6	40	58	GO:0005938; C:cell cortex; TAS:MGI.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI.
307	Q58DL7	561	ARHG9_BOVIN Rho guanine nucleotide exchange f...	52	0.0003	46.6	40	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
308	Q95UN8	1161	M3KSL_DROME Mitogen-activated protein kinase ...	54	0.0003	47	39	59
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004706; F:JUN kinase kinase kinase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
									GO:0007257; P:activation of JUN kinase activity; IMP:UniProtKB.::GO:0071361; P:cellular response to ethanol; IMP:FlyBase.::GO:0046843; P:dorsal appendage formation; IMP:FlyBase.::GO:0007394; P:dorsal closure, elongation of leading edge cells; IMP:FlyBase.::GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.::GO:0048804; P:imaginal disc-derived female genitalia morphogenesis; IMP:FlyBase.::GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase.::GO:0046330; P:positive regulation of JNK cascade; IMP:FlyBase.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
309	P16885	1265	PLCG2_HUMAN 1-phosphatidylinositol 4,5-bispho...	67	0.0003	47	40	52	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
									GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
									GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; TAS:UniProtKB.
310	P42681	527	TXK_HUMAN Tyrosine-protein kinase TXK OS=Homo...	52	0.0004	46.6	44	58	GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:ProtInc.::GO:0001012; F:RNA polymerase II regulatory region DNA binding; IDA:UniProtKB.
									GO:0007202; P:activation of phospholipase C activity; ISS:UniProtKB.::GO:0002250; P:adaptive immune response; ISS:UniProtKB.::GO:0032729; P:positive regulation of interferon-gamma production; IDA:UniProtKB.::GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
311	P15891	592	ABP1_YEAST Actin-binding protein OS=Saccharom...	51	0.0004	46.6	45	59	GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.
									GO:0051015; F:actin filament binding; IDA:SGD.
									GO:0000147; P:actin cortical patch assembly; IMP:SGD.::GO:0008104; P:protein localization; IMP:SGD.
312	Q80U22	1514	RUSC2_MOUSE Iporin OS=Mus musculus (Mouse). G...	103	0.0004	46.6	31	48	GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
313	A4QTV1	713	VPS27_MAGO7 Vacuolar protein sorting-associat...	328	0.0004	46.6	22	38	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0043581; P:mycelium development; IEP:PAMGO_MGG.
314	Q8CJ00	444	NOXA1_MOUSE NADPH oxidase activator 1 OS=Mus ...	67	0.0004	46.2	33	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:MGI.
									GO:0006801; P:superoxide metabolic process; IDA:MGI.
315	Q8VDG6	1002	M3KL4_MOUSE Mitogen-activated protein kinase ...	52	0.0004	46.6	44	58
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
316	Q04929	305	CRK_CHICK Adapter molecule crk OS=Gallus gall...	60	0.0005	45.8	35	57	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
317	O74352	466	HOB1_SCHPO Protein hob1 OS=Schizosaccharomyce...	52	0.0005	45.8	44	52	GO:0051285; C:cell cortex of cell tip; TAS:PomBase.::GO:0031097; C:medial cortex; TAS:PomBase.
									GO:0051020; F:GTPase binding; NAS:PomBase.
									GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0007163; P:establishment or maintenance of cell polarity; IGI:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0006974; P:response to DNA damage stimulus; IGI:PomBase.::GO:0000723; P:telomere maintenance; IMP:PomBase.
318	P42682	527	TXK_MOUSE Tyrosine-protein kinase TXK OS=Mus ...	52	0.0005	45.8	42	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
									GO:0007202; P:activation of phospholipase C activity; IMP:UniProtKB.::GO:0002250; P:adaptive immune response; IMP:UniProtKB.::GO:0032609; P:interferon-gamma production; IGI:MGI.::GO:0032633; P:interleukin-4 production; IGI:MGI.::GO:0001865; P:NK T cell differentiation; IGI:MGI.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
319	Q9R0C8	847	VAV3_MOUSE Guanine nucleotide exchange factor...	109	0.0005	46.2	28	44	GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
									GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI.
									GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI.::GO:0006906; P:vesicle fusion; IGI:MGI.
320	Q0CJV3	556	VPS27_ASPTN Vacuolar protein sorting-associat...	118	0.0006	45.8	26	54	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
321	P38479	617	ABP1_SACEX Actin-binding protein OS=Saccharom...	50	0.0006	45.8	46	56	GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.
322	O43586	416	PPIP1_HUMAN Proline-serine-threonine phosphat...	52	0.0007	45.4	37	50	GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016491; F:oxidoreductase activity; IEA:InterPro.
									GO:0007155; P:cell adhesion; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0035872; P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; TAS:Reactome.
323	O94868	740	FCSD2_HUMAN FCH and double SH3 domains protei...	49	0.0007	45.8	41	61
									GO:0005515; F:protein binding; IPI:IntAct.
324	Q8CIH5	1265	PLCG2_MOUSE 1-phosphatidylinositol 4,5-bispho...	67	0.0007	45.8	39	52	GO:0005829; C:cytosol; IMP:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
									GO:0032237; P:activation of store-operated calcium channel activity; IMP:MGI.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0002316; P:follicular B cell differentiation; IMP:MGI.::GO:0032959; P:inositol trisphosphate biosynthetic process; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043069; P:negative regulation of programmed cell death; IMP:MGI.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010468; P:regulation of gene expression; IMP:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.::GO:0050852; P:T cell receptor signaling pathway; IDA:MGI.
325	Q05876	534	FYN_CHICK Tyrosine-protein kinase Fyn OS=Gall...	69	0.0007	45.4	36	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0015631; F:tubulin binding; ISS:AgBase.
									GO:0030900; P:forebrain development; ISS:AgBase.::GO:0001764; P:neuron migration; ISS:AgBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:AgBase.::GO:0008360; P:regulation of cell shape; ISS:AgBase.
326	P87378	296	CRK_XENLA Adapter molecule crk OS=Xenopus lae...	67	0.0008	45.1	34	52	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB.
327	P24135	1265	PLCG2_RAT 1-phosphatidylinositol 4,5-bisphosp...	67	0.0008	45.8	39	52	GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
									GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.::GO:0033198; P:response to ATP; IDA:RGD.::GO:0032026; P:response to magnesium ion; IDA:RGD.
328	Q4P7Q1	916	VPS27_USTMA Vacuolar protein sorting-associat...	112	0.0009	45.4	25	53	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
329	Q3USJ8	740	FCSD2_MOUSE FCH and double SH3 domains protei...	49	0.0009	45.4	41	61
330	P13406	537	FYN_XENLA Tyrosine-protein kinase Fyn OS=Xeno...	69	0.0009	45.4	36	45
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
									GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
331	Q91ZR2	614	SNX18_MOUSE Sorting nexin-18 OS=Mus musculus ...	56	0.001	45.1	41	61	GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
									GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
									GO:0007154; P:cell communication; IEA:InterPro.::GO:0006897; P:endocytosis; ISS:UniProtKB.::GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.

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