Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YHL002W
Length:
452
Number of sequences:
5887
Description:
YHL002W HSE1 SGDID:S000000994, Chr VIII from 102612-103970, Genome Release 64-1-1, Verified ORF, "Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
151Q8I1I3    369   SH3G3_DROER Endophilin-A OS=Drosophila erecta...480.0000006     55.1     46     69GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0042171; F:lysophosphatidic acid acyltransferase activity; ISS:UniProtKB.
GO:0050803; P:regulation of synapse structure and activity; ISS:UniProtKB.::GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
152Q71F54    894   SH3R1_RAT E3 ubiquitin-protein ligase SH3RF1 ...560.85     35.8     30     52GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006917; P:induction of apoptosis; IMP:RGD.
153O43150    1006   ASAP2_HUMAN Arf-GAP with SH3 domain, ANK repe...600.0000006     55.8     40     65GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
154P70248    1099   MYO1F_MOUSE Unconventional myosin-If OS=Mus m...540.0000006     55.8     48     57GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
155Q557J6    481   DBNL_DICDI Drebrin-like protein OS=Dictyostel...580.0000006     55.1     45     64GO:0031252; C:cell leading edge; IDA:dictyBase.::GO:0030864; C:cortical actin cytoskeleton; IDA:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0097203; C:phagocytic cup lip; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; ISS:dictyBase.::GO:0032037; F:myosin I heavy chain binding; IPI:dictyBase.::GO:0005522; F:profilin binding; IPI:dictyBase.::GO:0019901; F:protein kinase binding; IPI:dictyBase.
GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0050765; P:negative regulation of phagocytosis; IMP:dictyBase.::GO:0031269; P:pseudopodium assembly; IMP:dictyBase.
156Q8IVI9    506   NOSTN_HUMAN Nostrin OS=Homo sapiens (Human). ...600.0000006     55.1     38     53GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.::GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
157Q7Z6J0    888   SH3R1_HUMAN E3 ubiquitin-protein ligase SH3RF...560.72     36.2     30     52GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
158Q14155    803   ARHG7_HUMAN Rho guanine nucleotide exchange f...500.0000006     55.5     50     56GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:BHF-UCL.::GO:0043025; C:neuronal cell body; IDA:BHF-UCL.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043547; P:positive regulation of GTPase activity; IDA:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
159Q555L8    389   Y4695_DICDI SH3 and FCH domain-containing pro...550.0000007     54.7     38     64
160Q9Z0W5    441   PACN1_RAT Protein kinase C and casein kinase ...560.0000008     54.7     50     64
GO:0007010; P:cytoskeleton organization; IDA:RGD.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
161Q5R411    444   PACN1_PONAB Protein kinase C and casein kinas...560.0000008     54.7     50     64
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
162Q5I0D6    502   NOSTN_RAT Nostrin OS=Rattus norvegicus (Rat)....530.0000008     55.1     40     57GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
163Q61644    441   PACN1_MOUSE Protein kinase C and casein kinas...560.0000008     54.7     50     64GO:0030137; C:COPI-coated vesicle; IDA:MGI.
GO:0008092; F:cytoskeletal protein binding; IDA:MGI.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; IDA:MGI.::GO:0007165; P:signal transduction; TAS:MGI.
164Q9BY11    444   PACN1_HUMAN Protein kinase C and casein kinas...560.0000008     54.7     50     64
GO:0004672; F:protein kinase activity; NAS:UniProtKB.
GO:0006897; P:endocytosis; NAS:UniProtKB.
165Q8N157    1196   AHI1_HUMAN Jouberin OS=Homo sapiens (Human). ...510.0000008     55.5     47     63GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IDA:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
166O00160    1098   MYO1F_HUMAN Unconventional myosin-If OS=Homo ...540.0000009     55.1     48     57GO:0016461; C:unconventional myosin complex; NAS:UniProtKB.
GO:0003779; F:actin binding; NAS:UniProtKB.::GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro.
167P02549    2419   SPTA1_HUMAN Spectrin alpha chain, erythrocyte...560.000001     55.1     41     59GO:0005829; C:cytosol; TAS:Reactome.::GO:0031235; C:intrinsic to internal side of plasma membrane; TAS:BHF-UCL.::GO:0008091; C:spectrin; TAS:ProtInc.::GO:0014731; C:spectrin-associated cytoskeleton; IDA:BHF-UCL.
GO:0051015; F:actin filament binding; TAS:ProtInc.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0007015; P:actin filament organization; TAS:ProtInc.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
168Q5XGP7    330   SKA2A_XENLA Src kinase-associated phosphoprot...1010.000001     54.3     28     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
169Q7SIG6    958   ASAP2_MOUSE Arf-GAP with SH3 domain, ANK repe...600.000001     55.1     40     63GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
170O97902    1129   ASAP1_BOVIN Arf-GAP with SH3 domain, ANK repe...600.000001     55.1     37     63GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0060271; P:cilium morphogenesis; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
171P13395    2415   SPTCA_DROME Spectrin alpha chain OS=Drosophil...780.000001     55.1     36     53GO:0016323; C:basolateral plasma membrane; IDA:FlyBase.::GO:0005938; C:cell cortex; IDA:FlyBase.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0045169; C:fusome; IDA:FlyBase.::GO:0005794; C:Golgi apparatus; IDA:FlyBase.::GO:0031594; C:neuromuscular junction; IDA:FlyBase.::GO:0045170; C:spectrosome; IDA:FlyBase.
GO:0003779; F:actin binding; IDA:FlyBase.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; IDA:FlyBase.
GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.::GO:0016199; P:axon midline choice point recognition; IGI:FlyBase.::GO:0007417; P:central nervous system development; IMP:FlyBase.::GO:0045478; P:fusome organization; TAS:FlyBase.::GO:0030727; P:germarium-derived female germ-line cyst formation; IMP:FlyBase.::GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.::GO:0042062; P:long-term strengthening of neuromuscular junction; IMP:FlyBase.::GO:0048790; P:maintenance of presynaptic active zone structure; IDA:FlyBase.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.::GO:0007308; P:oocyte construction; IMP:FlyBase.::GO:0030707; P:ovarian follicle cell development; TAS:FlyBase.::GO:0007009; P:plasma membrane organization; TAS:FlyBase.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.::GO:0030721; P:spectrosome organization; TAS:FlyBase.
172Q9QY17    488   PACN2_RAT Protein kinase C and casein kinase ...560.000001     54.3     50     64GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
173P62484    446   ABI2_MOUSE Abl interactor 2 OS=Mus musculus (...570.000001     54.3     40     68GO:0005913; C:cell-cell adherens junction; IDA:MGI.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IDA:MGI.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO:0043010; P:camera-type eye development; IMP:MGI.::GO:0016477; P:cell migration; IMP:MGI.::GO:0016358; P:dendrite development; IMP:MGI.::GO:0007611; P:learning or memory; IMP:MGI.
174Q9UNF0    486   PACN2_HUMAN Protein kinase C and casein kinas...560.000001     54.3     50     64GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005215; F:transporter activity; TAS:ProtInc.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
175Q9WVE8    486   PACN2_MOUSE Protein kinase C and casein kinas...560.000001     54.3     50     64GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.
GO:0008092; F:cytoskeletal protein binding; IDA:MGI.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; IDA:MGI.::GO:0007165; P:signal transduction; TAS:MGI.
176Q9NYB9    513   ABI2_HUMAN Abl interactor 2 OS=Homo sapiens (...600.000001     54.3     38     68GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:BHF-UCL.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.
GO:0008093; F:cytoskeletal adaptor activity; TAS:UniProtKB.::GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0019900; F:kinase binding; NAS:UniProtKB.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IPI:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
GO:0008154; P:actin polymerization or depolymerization; NAS:UniProtKB.::GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.
177Q9P7E8    857   APP1_SCHPO Protein app1 OS=Schizosaccharomyce...298.9     32.7     48     59GO:0030479; C:actin cortical patch; IDA:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.
GO:0003779; F:actin binding; IEA:InterPro.
GO:0030036; P:actin cytoskeleton organization; IC:PomBase.
178Q6XZF7    1577   DNMBP_HUMAN Dynamin-binding protein OS=Homo s...630.031     40.8     35     51GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
179Q8I1A6    366   SH3G3_DROWI Endophilin-A OS=Drosophila willis...480.000002     53.5     44     67GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0042171; F:lysophosphatidic acid acyltransferase activity; ISS:UniProtKB.
GO:0050803; P:regulation of synapse structure and activity; ISS:UniProtKB.::GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
180Q6DTM3    1047   AHI1_RAT Jouberin OS=Rattus norvegicus (Rat)....510.000002     53.9     47     63GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; ISS:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
181O55043    646   ARHG7_RAT Rho guanine nucleotide exchange fac...530.000002     53.9     47     53GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0043615; P:astrocyte cell migration; IMP:RGD.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:RGD.
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