Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR278W
Length:
577
Number of sequences:
5887
Description:
YGR278W CWC22 SGDID:S000003510, Chr VII from 1046731-1048464, Genome Release 64-1-1, Verified ORF, "Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P53333    577   CWC22_YEAST Pre-mRNA-splicing factor CWC22 OS...5770     1183     100     100GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005684; C:U2-type spliceosomal complex; IDA:SGD.
GO:0005488; F:binding; IEA:InterPro.
GO:0000398; P:nuclear mRNA splicing, via spliceosome; IDA:SGD.
2Q751P4    554   CWC22_ASHGO Pre-mRNA-splicing factor CWC22 OS...4832e-81     271     34     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
3P0CM96    831   CWC22_CRYNJ Pre-mRNA-splicing factor CWC22 OS...5003e-72     253     30     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
4P0CM97    831   CWC22_CRYNB Pre-mRNA-splicing factor CWC22 OS...5003e-72     253     30     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
5Q9P6R9    887   CWC22_SCHPO Pre-mRNA-splicing factor cwf22 OS...5122e-69     245     29     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; ISS:PomBase.
GO:0005488; F:binding; IEA:InterPro.
GO:0045292; P:nuclear mRNA cis splicing, via spliceosome; ISS:PomBase.
6Q6BU84    637   CWC22_DEBHA Pre-mRNA-splicing factor CWC22 OS...5121e-65     231     32     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
7Q8C5N3    908   CWC22_MOUSE Pre-mRNA-splicing factor CWC22 ho...5255e-64     230     31     54GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
8Q4PCY0    886   CWC22_USTMA Pre-mRNA-splicing factor CWC22 OS...5058e-64     229     30     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
9Q4WKB9    881   CWC22_ASPFU Pre-mRNA-splicing factor cwc22 OS...5015e-63     227     30     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
10Q52B63    907   CWC22_MAGO7 Pre-mRNA-splicing factor CWC22 OS...4991e-62     226     29     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
11Q9HCG8    908   CWC22_HUMAN Pre-mRNA-splicing factor CWC22 ho...5227e-62     224     30     53GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:HPA.
GO:0003723; F:RNA binding; IDA:UniProtKB.
GO:0000398; P:nuclear mRNA splicing, via spliceosome; IC:UniProtKB.::GO:0048024; P:regulation of nuclear mRNA splicing, via spliceosome; IC:UniProtKB.
12Q5BGP1    868   CWC22_EMENI Pre-mRNA-splicing factor cwc22 OS...4982e-61     223     30     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
13Q17336    897   CWC22_CAEEL Pre-mRNA-splicing factor CWC22 ho...5045e-61     221     28     52GO:0043073; C:germ cell nucleus; IDA:WormBase.::GO:0000790; C:nuclear chromatin; IDA:WormBase.::GO:0005654; C:nucleoplasm; IDA:WormBase.::GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007369; P:gastrulation; IMP:WormBase.::GO:0042078; P:germ-line stem cell division; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
14Q5RA93    908   CWC22_PONAB Pre-mRNA-splicing factor CWC22 ho...5226e-61     221     30     53GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
15Q08C72    985   CWC22_DANRE Pre-mRNA-splicing factor CWC22 ho...5177e-61     221     29     54GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
16Q7RX84    1010   CWC22_NEUCR Pre-mRNA-splicing factor cwc-22 O...5051e-59     218     30     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
17A8WT19    935   CWC22_CAEBR Pre-mRNA-splicing factor CWC22 ho...5243e-59     216     29     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
18Q52KN9    803   CWC22_XENLA Pre-mRNA-splicing factor CWC22 ho...5061e-58     214     29     54GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
19Q9VJ87    1330   CWC22_DROME Pre-mRNA-splicing factor CWC22 ho...4962e-58     216     29     52GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
20Q5ZKA3    926   CWC22_CHICK Pre-mRNA-splicing factor CWC22 ho...5037e-56     206     29     53GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
21Q59XY0    648   CWC22_CANAL Pre-mRNA-splicing factor CWC22 OS...6261e-52     195     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
22Q6C8C5    954   CWC22_YARLI Pre-mRNA-splicing factor CWC22 OS...5452e-35     145     26     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0005488; F:binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
23Q3UFM5    854   NOM1_MOUSE Nucleolar MIF4G domain-containing ...1220.0000008     55.8     25     53GO:0005730; C:nucleolus; ISS:UniProtKB.
GO:0005488; F:binding; IEA:InterPro.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
24Q5C9Z4    860   NOM1_HUMAN Nucleolar MIF4G domain-containing ...1360.00003     50.8     22     51GO:0005730; C:nucleolus; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
25Q9W020    854   NOM1_DROME Nucleolar MIF4G domain-containing ...1600.001     45.8     25     48GO:0005730; C:nucleolus; ISS:UniProtKB.
GO:0005488; F:binding; IEA:InterPro.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
26Q8BTI8    2703   SRRM2_MOUSE Serine/arginine repetitive matrix...393.2     34.7     46     67GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
27Q9WUD9    536   SRC_RAT Proto-oncogene tyrosine-protein kinas...340.21     38.1     47     65GO:0005901; C:caveola; IDA:RGD.::GO:0005829; C:cytosol; NAS:UniProtKB.::GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0050839; F:cell adhesion molecule binding; IPI:RGD.::GO:0030331; F:estrogen receptor binding; IPI:RGD.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0005158; F:insulin receptor binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0005080; F:protein kinase C binding; IPI:RGD.
GO:0032148; P:activation of protein kinase B activity; IMP:UniProtKB.::GO:0034332; P:adherens junction organization; IDA:RGD.::GO:0045453; P:bone resorption; ISS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; IDA:RGD.::GO:0016337; P:cell-cell adhesion; IEP:RGD.::GO:0071398; P:cellular response to fatty acid; IEP:RGD.::GO:0071456; P:cellular response to hypoxia; IEP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.::GO:0007173; P:epidermal growth factor receptor signaling pathway; IEP:RGD.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; IDA:RGD.::GO:0018105; P:peptidyl-serine phosphorylation; IMP:UniProtKB.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEP:RGD.::GO:0043065; P:positive regulation of apoptotic process; IDA:RGD.::GO:0045785; P:positive regulation of cell adhesion; IDA:RGD.::GO:0045737; P:positive regulation of cyclin-dependent protein kinase activity; IMP:UniProtKB.::GO:0050715; P:positive regulation of cytokine secretion; IMP:RGD.::GO:2000573; P:positive regulation of DNA biosynthetic process; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0010907; P:positive regulation of glucose metabolic process; IMP:RGD.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; IDA:RGD.::GO:0043406; P:positive regulation of MAP kinase activity; IMP:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB.::GO:0010641; P:positive regulation of platelet-derived growth factor receptor signaling pathway; IEP:UniProtKB.::GO:0031954; P:positive regulation of protein autophosphorylation; IMP:UniProtKB.::GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0001101; P:response to acid; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0051602; P:response to electrical stimulus; IEP:RGD.::GO:0042542; P:response to hydrogen peroxide; IEP:RGD.::GO:0009612; P:response to mechanical stimulus; IEP:RGD.::GO:0051385; P:response to mineralocorticoid stimulus; IEP:RGD.::GO:0031667; P:response to nutrient levels; IEP:RGD.::GO:0009615; P:response to virus; IEP:RGD.::GO:0045056; P:transcytosis; IDA:RGD.
28P15054    587   SRC_AVIS2 Tyrosine-protein kinase transformin...270.6     36.6     56     70
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
29P14085    557   SRC_AVIST Tyrosine-protein kinase transformin...270.62     36.6     56     70
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
30P12931    536   SRC_HUMAN Proto-oncogene tyrosine-protein kin...270.65     36.6     56     70GO:0005901; C:caveola; IDA:BHF-UCL.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0020037; F:heme binding; IDA:UniProtKB.::GO:0005178; F:integrin binding; TAS:BHF-UCL.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:BHF-UCL.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0045453; P:bone resorption; ISS:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; IDA:BHF-UCL.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0033625; P:positive regulation of integrin activation; TAS:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0045124; P:regulation of bone resorption; TAS:BHF-UCL.::GO:0043114; P:regulation of vascular permeability; TAS:BHF-UCL.::GO:0070555; P:response to interleukin-1; IMP:BHF-UCL.::GO:0007172; P:signal complex assembly; TAS:ProtInc.::GO:0031295; P:T cell costimulation; TAS:Reactome.
31P14084    568   SRC_AVISS Tyrosine-protein kinase transformin...270.66     36.6     56     70
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
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