| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P51601 | 243 | GCH1_YEAST GTP cyclohydrolase 1 OS=Saccharomy... | 243 | 0 | 504 | 100 | 100 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IMP:SGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 2 | O13774 | 235 | GCH1_SCHPO GTP cyclohydrolase 1 OS=Schizosacc... | 229 | 4e-100 | 298 | 63 | 80 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; ISS:PomBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 3 | P51599 | 313 | GCH1_NEUCR GTP cyclohydrolase 1 OS=1257 / FGS... | 224 | 3e-96 | 291 | 60 | 82 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 4 | O61573 | 213 | GCH1_OSTOS GTP cyclohydrolase 1 OS=Ostertagia... | 189 | 8e-88 | 266 | 66 | 83 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 5 | Q19980 | 223 | GCH1_CAEEL GTP cyclohydrolase 1 OS=Caenorhabd... | 189 | 3e-86 | 262 | 65 | 83 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0042416; P:dopamine biosynthetic process; IMP:WormBase.::GO:0042438; P:melanin biosynthetic process; IMP:WormBase.::GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 6 | Q05915 | 241 | GCH1_MOUSE GTP cyclohydrolase 1 OS=Mus muscul... | 239 | 2e-84 | 258 | 54 | 72 | | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IDA:MGI. | | | | | | | | | | GO:0014916; P:regulation of lung blood pressure; IMP:MGI.::GO:0048265; P:response to pain; ISS:UniProtKB.::GO:0006729; P:tetrahydrobiopterin biosynthetic process; IC:MGI.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 7 | P30793 | 250 | GCH1_HUMAN GTP cyclohydrolase 1 OS=Homo sapie... | 211 | 3e-84 | 258 | 59 | 77 | GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031965; C:nuclear membrane; IDA:HPA.::GO:0043234; C:protein complex; IDA:UniProtKB. | | | | | | | | | | GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0003934; F:GTP cyclohydrolase I activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0042416; P:dopamine biosynthetic process; IDA:UniProtKB.::GO:0006184; P:GTP catabolic process; IDA:UniProtKB.::GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.::GO:0006809; P:nitric oxide biosynthetic process; NAS:UniProtKB.::GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:UniProtKB.::GO:0051260; P:protein homooligomerization; IDA:UniProtKB.::GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.::GO:0048265; P:response to pain; ISS:UniProtKB.::GO:0034612; P:response to tumor necrosis factor; IDA:UniProtKB.::GO:0006729; P:tetrahydrobiopterin biosynthetic process; IDA:UniProtKB.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 8 | P22288 | 241 | GCH1_RAT GTP cyclohydrolase 1 OS=Rattus norve... | 210 | 2e-82 | 253 | 59 | 77 | GO:0043234; C:protein complex; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IDA:RGD.::GO:0050662; F:coenzyme binding; IDA:RGD.::GO:0005525; F:GTP binding; IDA:RGD.::GO:0003934; F:GTP cyclohydrolase I activity; IDA:RGD.::GO:0030742; F:GTP-dependent protein binding; IPI:RGD.::GO:0008270; F:zinc ion binding; IDA:RGD. | | | | | | | | | | GO:0051066; P:dihydrobiopterin metabolic process; IDA:RGD.::GO:0006917; P:induction of apoptosis; IEP:RGD.::GO:0045776; P:negative regulation of blood pressure; IMP:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0051260; P:protein homooligomerization; IDA:RGD.::GO:0048265; P:response to pain; IDA:UniProtKB.::GO:0006729; P:tetrahydrobiopterin biosynthetic process; TAS:RGD.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.::GO:0042311; P:vasodilation; IMP:RGD. | 9 | P50141 | 236 | GCH1_CHICK GTP cyclohydrolase 1 OS=Gallus gal... | 190 | 9e-82 | 251 | 64 | 81 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 10 | Q94465 | 232 | GCH1_DICDI GTP cyclohydrolase 1 OS=Dictyostel... | 184 | 1e-77 | 240 | 61 | 82 | GO:0005624; C:membrane fraction; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0005625; C:soluble fraction; IDA:dictyBase. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IDA:dictyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:dictyBase.::GO:0006729; P:tetrahydrobiopterin biosynthetic process; IDA:dictyBase.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 11 | Q8YLL1 | 235 | GCH11_NOSS1 GTP cyclohydrolase 1 1 OS=Nostoc ... | 194 | 2e-77 | 240 | 59 | 77 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 12 | Q8DJB8 | 229 | GCH1_THEEB GTP cyclohydrolase 1 OS=Thermosyne... | 181 | 7e-77 | 238 | 62 | 79 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 13 | B2J1L7 | 235 | GCH1_NOSP7 GTP cyclohydrolase 1 OS=Nostoc pun... | 186 | 3e-76 | 237 | 59 | 80 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 14 | Q5N623 | 213 | GCH1_SYNP6 GTP cyclohydrolase 1 OS=(Anacystis... | 179 | 1e-75 | 234 | 61 | 80 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 15 | Q54769 | 213 | GCH1_SYNE7 GTP cyclohydrolase 1 OS=Synechococ... | 179 | 1e-75 | 234 | 61 | 80 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 16 | Q55759 | 234 | GCH1_SYNY3 GTP cyclohydrolase 1 OS=Synechocys... | 181 | 7e-75 | 233 | 59 | 80 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 17 | Q9I351 | 181 | GCH12_PSEAE GTP cyclohydrolase 1 2 OS=12228).... | 173 | 1e-73 | 228 | 61 | 80 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 18 | Q8YN49 | 216 | GCH12_NOSS1 GTP cyclohydrolase 1 2 OS=Nostoc ... | 200 | 3e-72 | 226 | 57 | 74 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 19 | Q607T5 | 185 | GCH1_METCA GTP cyclohydrolase 1 OS=Methylococ... | 175 | 2e-71 | 223 | 60 | 77 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 20 | Q7NK98 | 214 | GCH1_GLOVI GTP cyclohydrolase 1 OS=Gloeobacte... | 194 | 1e-70 | 222 | 53 | 77 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 21 | Q2JPT8 | 229 | GCH1_SYNJB GTP cyclohydrolase 1 OS=Yellowston... | 177 | 2e-70 | 222 | 57 | 80 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 22 | Q2JR69 | 229 | GCH1_SYNJA GTP cyclohydrolase 1 OS=Yellowston... | 177 | 2e-70 | 222 | 59 | 79 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 23 | Q0A939 | 185 | GCH1_ALHEH GTP cyclohydrolase 1 OS=Alkalilimn... | 181 | 4e-70 | 219 | 58 | 75 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 24 | P48596 | 324 | GCH1_DROME GTP cyclohydrolase 1 OS=Drosophila... | 179 | 7e-70 | 223 | 62 | 82 | GO:0005737; C:cytoplasm; IDA:FlyBase. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IDA:FlyBase.::GO:0060308; F:GTP cyclohydrolase I regulator activity; IDA:FlyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0048072; P:compound eye pigmentation; IMP:FlyBase.::GO:0048067; P:cuticle pigmentation; IMP:FlyBase.::GO:0009880; P:embryonic pattern specification; IMP:FlyBase.::GO:0008363; P:larval chitin-based cuticle development; IMP:FlyBase.::GO:0035185; P:preblastoderm mitotic cell cycle; IMP:FlyBase.::GO:0006728; P:pteridine biosynthetic process; IMP:FlyBase.::GO:2000274; P:regulation of epithelial cell migration, open tracheal system; IMP:FlyBase.::GO:0043095; P:regulation of GTP cyclohydrolase I activity; IDA:FlyBase.::GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 25 | Q9HYG8 | 186 | GCH11_PSEAE GTP cyclohydrolase 1 1 OS=12228).... | 181 | 2e-69 | 218 | 57 | 74 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 26 | Q7MWI5 | 193 | GCH1_PORGI GTP cyclohydrolase 1 OS=Porphyromo... | 192 | 3e-69 | 218 | 54 | 71 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 27 | B2RIJ1 | 193 | GCH1_PORG3 GTP cyclohydrolase 1 OS=Porphyromo... | 192 | 3e-69 | 218 | 54 | 71 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 28 | Q884Q3 | 181 | GCH12_PSESM GTP cyclohydrolase 1 2 OS=Pseudom... | 173 | 4e-69 | 217 | 58 | 76 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 29 | C1DHG2 | 181 | GCH1_AZOVD GTP cyclohydrolase 1 OS=Azotobacte... | 173 | 9e-69 | 216 | 57 | 78 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 30 | Q3IF89 | 184 | GCH1_PSEHT GTP cyclohydrolase 1 OS=Pseudoalte... | 174 | 2e-68 | 215 | 58 | 76 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. | 31 | Q15YG1 | 184 | GCH1_PSEA6 GTP cyclohydrolase 1 OS=Pseudoalte... | 174 | 2e-68 | 215 | 57 | 75 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003934; F:GTP cyclohydrolase I activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro. |
