Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR231C
Length:
310
Number of sequences:
5887
Description:
YGR231C PHB2 SGDID:S000003463, Chr VII from 953480-952548, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P50085    310   PHB2_YEAST Prohibitin-2 OS=Saccharomyces cere...3100     631     100     100GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0000001; P:mitochondrion inheritance; IMP:SGD.::GO:0045861; P:negative regulation of proteolysis; IPI:SGD.::GO:0006457; P:protein folding; IDA:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.
2O94550    288   PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyce...2853e-128     374     66     81GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
GO:0006457; P:protein folding; ISS:PomBase.
3Q54Q31    293   PHB2_DICDI Prohibitin-2 OS=Dictyostelium disc...2424e-110     328     64     84GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
4A9UMS3    301   PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis...2746e-103     310     57     77GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q2HJ97    299   PHB2_BOVIN Prohibitin-2 OS=Bos taurus (Bovine...2748e-102     307     56     78GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6Q5XIH7    299   PHB2_RAT Prohibitin-2 OS=Rattus norvegicus (R...2743e-101     306     55     78GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7O35129    299   PHB2_MOUSE Prohibitin-2 OS=Mus musculus (Mous...2749e-101     305     55     78GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0060749; P:mammary gland alveolus development; IMP:MGI.::GO:0060744; P:mammary gland branching involved in thelarche; IMP:MGI.::GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IMP:MGI.::GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8Q99623    299   PHB2_HUMAN Prohibitin-2 OS=Homo sapiens (Huma...2749e-101     305     55     78GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0030331; F:estrogen receptor binding; NAS:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9Q5RB19    299   PHB2_PONAB Prohibitin-2 OS=Pongo abelii (Suma...2741e-99     301     55     77GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10P40961    287   PHB1_YEAST Prohibitin-1 OS=Saccharomyces cere...2413e-96     292     59     79GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0007007; P:inner mitochondrial membrane organization; IMP:SGD.::GO:0000001; P:mitochondrion inheritance; IMP:SGD.::GO:0070584; P:mitochondrion morphogenesis; IMP:SGD.::GO:0045861; P:negative regulation of proteolysis; IPI:SGD.::GO:0006457; P:protein folding; IPI:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.
11Q54GI9    271   PHB1_DICDI Prohibitin-1, mitochondrial OS=Dic...2401e-95     290     54     79GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
12P50093    294   PHB2_CAEEL Mitochondrial prohibitin complex p...2423e-95     290     56     79GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0030421; P:defecation; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0070584; P:mitochondrion morphogenesis; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0002082; P:regulation of oxidative phosphorylation; IMP:WormBase.::GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.::GO:0006979; P:response to oxidative stress; IMP:WormBase.::GO:0007283; P:spermatogenesis; IMP:WormBase.
13Q5ZMN3    301   PHB2_CHICK Prohibitin-2 OS=Gallus gallus (Chi...2463e-94     288     56     79GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14P67779    272   PHB_RAT Prohibitin OS=Rattus norvegicus (Rat)...2473e-91     279     53     75GO:0031315; C:extrinsic to mitochondrial outer membrane; IDA:RGD.::GO:0030061; C:mitochondrial crista; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0001552; P:ovarian follicle atresia; IEP:RGD.::GO:0001541; P:ovarian follicle development; IEP:RGD.::GO:0034097; P:response to cytokine stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.::GO:0006950; P:response to stress; IEP:RGD.
15P67778    272   PHB_MOUSE Prohibitin OS=Mus musculus (Mouse)....2473e-91     279     53     75GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
GO:0071897; P:DNA biosynthetic process; IMP:MGI.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
16P84173    272   PHB_CHICK Prohibitin OS=Gallus gallus (Chicke...2483e-91     279     53     75GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
17P35232    272   PHB_HUMAN Prohibitin OS=Homo sapiens (Human)....2471e-90     278     53     75GO:0005887; C:integral to plasma membrane; IDA:HGNC.::GO:0005743; C:mitochondrial inner membrane; TAS:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO:0071354; P:cellular response to interleukin-6; IDA:BHF-UCL.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0016575; P:histone deacetylation; IDA:UniProtKB.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL.::GO:2000323; P:negative regulation of glucocorticoid receptor signaling pathway; IDA:BHF-UCL.::GO:0010944; P:negative regulation of transcription by competitive promoter binding; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL.::GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
18Q3T165    272   PHB_BOVIN Prohibitin OS=Bos taurus (Bovine). ...2471e-90     278     53     75GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
19Q9P7H3    282   PHB1_SCHPO Prohibitin-1 OS=Schizosaccharomyce...2432e-90     278     53     79GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
GO:0007007; P:inner mitochondrial membrane organization; ISS:PomBase.::GO:0000001; P:mitochondrion inheritance; ISS:PomBase.::GO:0006457; P:protein folding; ISS:PomBase.
20P24156    276   L2CC_DROME Protein l(2)37Cc OS=Drosophila mel...2583e-87     269     52     72GO:0005811; C:lipid particle; IDA:FlyBase.::GO:0016020; C:membrane; IEA:InterPro.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.
GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
21Q9BKU4    275   PHB1_CAEEL Mitochondrial prohibitin complex p...2586e-77     243     50     71GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0030421; P:defecation; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0070584; P:mitochondrion morphogenesis; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0002082; P:regulation of oxidative phosphorylation; IMP:WormBase.::GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.::GO:0006979; P:response to oxidative stress; IMP:WormBase.::GO:0007283; P:spermatogenesis; IMP:WormBase.
22P86220    87   PHB_MESAU Prohibitin OS=Mesocricetus auratus ...1130.00000000000004     70.9     41     52GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
23Q58237    199   Y827_METJA Uncharacterized protein MJ0827 OS=...1880.014     39.7     23     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
24Q9FM19    286   HIR1_ARATH Hypersensitive-induced response pr...1870.49     35.4     24     42GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0043424; F:protein histidine kinase binding; IPI:UniProtKB.
25P57630    310   HFLC_BUCAI Protein HflC OS=(Acyrthosiphon pis...2700.62     35     20     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
26Q9SRH6    285   HIR3_ARATH Hypersensitive-induced response pr...2010.8     34.7     22     41GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0050832; P:defense response to fungus; IEP:TAIR.
27Q5UP73    303   YR614_MIMIV Putative band 7 family protein R6...2021.3     33.9     20     44GO:0016020; C:membrane; IEA:InterPro.
28B3E7B0    390   DXR_GEOLS 1-deoxy-D-xylulose 5-phosphate redu...1041.5     33.9     25     49
GO:0030604; F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0070402; F:NADPH binding; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
29O28852    249   Y1420_ARCFU Uncharacterized protein AF_1420 O...1991.7     33.5     23     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
30Q5WDW9    368   DDL_BACSK D-alanine--D-alanine ligase OS=Baci...642.6     33.1     33     56GO:0005618; C:cell wall; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007047; P:cellular cell wall organization; IEA:UniProtKB-KW.::GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.::GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
31P04932    1630   MSP1_PLAFK Merozoite surface protein 1 OS=Pla...1392.9     33.5     21     42GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0009405; P:pathogenesis; IEA:InterPro.
records
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