rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P07245 | 946 | C1TC_YEAST C-1-tetrahydrofolate synthase, cyt... | 946 | 0 | 1939 | 100 | 100 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IMP:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IMP:SGD. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; IMP:SGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 2 | P09440 | 975 | C1TM_YEAST C-1-tetrahydrofolate synthase, mit... | 948 | 0 | 1343 | 71 | 82 | GO:0005739; C:mitochondrion; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:SGD.::GO:0004479; F:methionyl-tRNA formyltransferase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:SGD. | | | | | | | | | | GO:0046656; P:folic acid biosynthetic process; IDA:SGD.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 3 | P27653 | 935 | C1TC_RAT C-1-tetrahydrofolate synthase, cytop... | 947 | 0 | 1050 | 57 | 73 | GO:0005737; C:cytoplasm; TAS:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:RGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:RGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:RGD. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEP:RGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; TAS:RGD.] | 4 | P11586 | 935 | C1TC_HUMAN C-1-tetrahydrofolate synthase, cyt... | 948 | 0 | 1050 | 58 | 72 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; TAS:ProtInc. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:Reactome.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:Reactome.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:Reactome. | | | | | | | | | | GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.] | 5 | Q922D8 | 935 | C1TC_MOUSE C-1-tetrahydrofolate synthase, cyt... | 947 | 0 | 1038 | 57 | 73 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IMP:MGI.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0006548; P:histidine catabolic process; IMP:MGI.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 6 | Q8WZJ7 | 937 | C1TC_SCHPO C-1-tetrahydrofolate synthase, cyt... | 946 | 0 | 1036 | 58 | 74 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:PomBase.::GO:0003697; F:single-stranded DNA binding; IDA:PomBase. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:PomBase.::GO:0046656; P:folic acid biosynthetic process; IDA:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IDA:PomBase.::GO:0009113; P:purine base biosynthetic process; IDA:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 7 | Q5R8P0 | 935 | C1TC_PONAB C-1-tetrahydrofolate synthase, cyt... | 948 | 0 | 1035 | 57 | 72 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 8 | O43007 | 969 | C1TM_SCHPO C-1-tetrahydrofolate synthase, mit... | 952 | 0 | 1015 | 55 | 71 | GO:0005739; C:mitochondrion; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; ISS:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; ISS:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; ISS:PomBase. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; ISS:PomBase.::GO:0046656; P:folic acid biosynthetic process; ISS:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; ISS:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 9 | O96553 | 968 | C1TC_DROME C-1-tetrahydrofolate synthase, cyt... | 951 | 0 | 961 | 54 | 69 | GO:0005737; C:cytoplasm; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; NAS:UniProtKB.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; NAS:UniProtKB.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; NAS:UniProtKB. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 10 | Q27772 | 933 | C1TC_SPOFR C-1-tetrahydrofolate synthase, cyt... | 938 | 0 | 942 | 53 | 69 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 11 | Q0VCR7 | 975 | C1TM_BOVIN Monofunctional C1-tetrahydrofolate... | 923 | 0 | 838 | 50 | 66 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 12 | Q6UB35 | 978 | C1TM_HUMAN Monofunctional C1-tetrahydrofolate... | 925 | 0 | 836 | 50 | 66 | GO:0005739; C:mitochondrion; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:BHF-UCL.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0015942; P:formate metabolic process; IDA:BHF-UCL.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:BHF-UCL. | 13 | Q3V3R1 | 977 | C1TM_MOUSE Monofunctional C1-tetrahydrofolate... | 927 | 0 | 818 | 50 | 66 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 14 | Q9SPK5 | 634 | FTHS_ARATH Formate--tetrahydrofolate ligase O... | 637 | 0 | 715 | 57 | 74 | GO:0048046; C:apoplast; IDA:TAIR.::GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005829; C:cytosol; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IDA:TAIR.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046686; P:response to cadmium ion; IEP:TAIR. | 15 | P28723 | 637 | FTHS_SPIOL Formate--tetrahydrofolate ligase O... | 637 | 0 | 714 | 57 | 73 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 16 | A7NGQ9 | 564 | FTHS_ROSCS Formate--tetrahydrofolate ligase O... | 624 | 0 | 557 | 48 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 17 | A5UPV2 | 564 | FTHS_ROSS1 Formate--tetrahydrofolate ligase O... | 624 | 0 | 548 | 48 | 65 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 18 | A4J0S6 | 567 | FTHS_DESRM Formate--tetrahydrofolate ligase O... | 630 | 3e-180 | 541 | 46 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 19 | A4FL80 | 565 | FTHS_SACEN Formate--tetrahydrofolate ligase O... | 626 | 6e-176 | 530 | 50 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 20 | A4SPE5 | 580 | FTHS_AERS4 Formate--tetrahydrofolate ligase O... | 628 | 1e-171 | 519 | 48 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 21 | Q2RM91 | 559 | FTHS_MOOTA Formate--tetrahydrofolate ligase O... | 631 | 1e-170 | 516 | 46 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 22 | Q6ABS5 | 563 | FTHS_PROAC Formate--tetrahydrofolate ligase O... | 625 | 2e-170 | 515 | 45 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 23 | A8MIN1 | 556 | FTHS_ALKOO Formate--tetrahydrofolate ligase O... | 625 | 3e-170 | 514 | 47 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 24 | B8J0C2 | 591 | FTHS_DESDA Formate--tetrahydrofolate ligase O... | 623 | 3e-169 | 513 | 47 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 25 | P21164 | 559 | FTHS_MOOTH Formate--tetrahydrofolate ligase O... | 631 | 5e-168 | 509 | 45 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 26 | A0KIN9 | 576 | FTHS_AERHH Formate--tetrahydrofolate ligase O... | 625 | 6e-167 | 507 | 50 | 66 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 27 | A9B4H8 | 570 | FTHS_HERA2 Formate--tetrahydrofolate ligase O... | 631 | 3e-166 | 505 | 45 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 28 | B0TBP1 | 556 | FTHS_HELMI Formate--tetrahydrofolate ligase O... | 626 | 3e-166 | 504 | 45 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 29 | B9LKW0 | 572 | FTHS_CHLSY Formate--tetrahydrofolate ligase O... | 620 | 1e-165 | 503 | 47 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 30 | A9WIW3 | 572 | FTHS_CHLAA Formate--tetrahydrofolate ligase O... | 620 | 1e-165 | 503 | 47 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 31 | Q8D7D8 | 582 | FTHS_VIBVU Formate--tetrahydrofolate ligase O... | 628 | 2e-165 | 503 | 45 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |