UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YGR188C

Length:

1021

Number of sequences:

5887

Description:

YGR188C BUB1 SGDID:S000003420, Chr VII from 875109-872044, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase involved in the cell cycle checkpoint into anaphase; forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage; CDC28-mediated phosphorylation at Bub1p-T566 is important for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function; associates with centromere DNA via Skp1p"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
991	P47812	361	MK14_XENLA Mitogen-activated protein kinase 1...	30	5.7	34.3	43	67
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
									GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
992	O14408	382	KCC1_METAN Calcium/calmodulin-dependent prote...	177	5.8	34.3	21	38
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
993	Q62074	595	KPCI_MOUSE Protein kinase C iota type OS=Mus ...	228	5.8	34.7	22	39	GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043220; C:Schmidt-Lanterman incisure; IDA:BHF-UCL.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0007015; P:actin filament organization; IMP:MGI.::GO:0045216; P:cell-cell junction organization; ISS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.::GO:0035089; P:establishment of apical/basal cell polarity; IMP:MGI.::GO:0042462; P:eye photoreceptor cell development; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:2000353; P:positive regulation of endothelial cell apoptotic process; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:BHF-UCL.::GO:0060252; P:positive regulation of glial cell proliferation; ISS:UniProtKB.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
994	F1M7Y5	596	KPCI_RAT Protein kinase C iota type OS=Rattus...	152	5.8	34.7	22	41	GO:0031252; C:cell leading edge; IDA:RGD.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0005524; F:ATP binding; IDA:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD.::GO:0004697; F:protein kinase C activity; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0016477; P:cell migration; IMP:RGD.::GO:0034613; P:cellular protein localization; IMP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IMP:RGD.::GO:0048194; P:Golgi vesicle budding; IDA:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:2000353; P:positive regulation of endothelial cell apoptotic process; ISS:UniProtKB.::GO:0060252; P:positive regulation of glial cell proliferation; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0070555; P:response to interleukin-1; IMP:RGD.
995	P54664	301	CC2H1_TRYCO Cell division control protein 2 h...	138	5.8	34.3	28	48
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
996	Q62844	537	FYN_RAT Tyrosine-protein kinase Fyn OS=Rattus...	135	5.8	34.3	22	45	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005792; C:microsome; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042609; F:CD4 receptor binding; IPI:RGD.::GO:0042610; F:CD8 receptor binding; IPI:RGD.::GO:0001948; F:glycoprotein binding; IPI:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0051428; F:peptide hormone receptor binding; IPI:RGD.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IDA:RGD.::GO:0042608; F:T cell receptor binding; IDA:RGD.
									GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.::GO:0071375; P:cellular response to peptide hormone stimulus; IEP:RGD.::GO:0035235; P:ionotropic glutamate receptor signaling pathway; TAS:RGD.::GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0042493; P:response to drug; IEP:RGD.
997	A1Y2K1	537	FYN_PIG Tyrosine-protein kinase Fyn OS=Sus sc...	135	5.8	34.3	22	45	GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
998	Q63531	735	KS6A1_RAT Ribosomal protein S6 kinase alpha-1...	74	6.6	34.3	30	47	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004711; F:ribosomal protein S6 kinase activity; TAS:RGD.::GO:0008134; F:transcription factor binding; IDA:RGD.
									GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:RGD.
999	Q9Z2B9	773	KS6A4_MOUSE Ribosomal protein S6 kinase alpha...	118	8.3	33.9	25	42	GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0048273; F:mitogen-activated protein kinase p38 binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
									GO:0043987; P:histone H3-S10 phosphorylation; ISS:UniProtKB.::GO:0043988; P:histone H3-S28 phosphorylation; ISS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.
1000	Q552Z2	1321	FNKE_DICDI Probable serine/threonine-protein ...	31	9	33.9	42	68
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.

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