Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR184C
Length:
1950
Number of sequences:
5887
Description:
YGR184C UBR1 SGDID:S000003416, Chr VII from 865753-859901, Genome Release 64-1-1, reverse complement, Verified ORF, "E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P19812    1950   UBR1_YEAST E3 ubiquitin-protein ligase UBR1 O...19500     4052     100     100GO:0005737; C:cytoplasm; IMP:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IMP:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071629; P:cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0000209; P:protein polyubiquitination; IMP:SGD.::GO:0090089; P:regulation of dipeptide transport; IMP:SGD.::GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IMP:SGD.
2O60014    1945   UBR1_KLULA E3 ubiquitin-protein ligase UBR1 O...19640     1800     48     65
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030163; P:protein catabolic process; IEA:InterPro.
3O60152    1958   UBR1_SCHPO E3 ubiquitin-protein ligase ubr1 O...1080.0001     51.2     33     50GO:0005634; C:nucleus; NAS:PomBase.
GO:0004842; F:ubiquitin-protein ligase activity; IMP:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:PomBase.::GO:0031144; P:proteasome localization; IMP:PomBase.::GO:0010570; P:regulation of filamentous growth; IMP:PomBase.
4O13731    2052   UBR11_SCHPO E3 ubiquitin-protein ligase ubr11...1600.14     41.2     25     41GO:0005634; C:nucleus; NAS:PomBase.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030163; P:protein catabolic process; IEA:InterPro.
5Q6WKZ8    1755   UBR2_MOUSE E3 ubiquitin-protein ligase UBR2 O...1920.022     43.5     22     39GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IGI:MGI.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071233; P:cellular response to leucine; ISS:UniProtKB.::GO:0006342; P:chromatin silencing; IDA:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; IDA:UniProtKB.::GO:0007141; P:male meiosis I; IMP:MGI.::GO:0032007; P:negative regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; IMP:MGI.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI.
6Q07963    1872   UBR2_YEAST E3 ubiquitin-protein ligase UBR2 O...1520.00005     52.4     27     45GO:0005737; C:cytoplasm; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006513; P:protein monoubiquitination; IDA:SGD.
7Q8IWV8    1755   UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 O...1920.39     39.7     21     39GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0070728; F:leucine binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071233; P:cellular response to leucine; IDA:UniProtKB.::GO:0006342; P:chromatin silencing; ISS:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; ISS:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.
8O70481    1757   UBR1_MOUSE E3 ubiquitin-protein ligase UBR1 O...1290.000000000004     75.9     35     46GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IGI:MGI.::GO:0000151; C:ubiquitin ligase complex; IGI:MGI.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071233; P:cellular response to leucine; ISS:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI.
9Q9VX91    1824   UBR1_DROME E3 ubiquitin-protein ligase UBR1 O...2410.0000000006     68.6     26     38
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030163; P:protein catabolic process; IEA:InterPro.
10Q8IWV7    1749   UBR1_HUMAN E3 ubiquitin-protein ligase UBR1 O...2230.003     46.6     21     36GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0070728; F:leucine binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071233; P:cellular response to leucine; IDA:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.
11P91133    2058   UBR1_CAEEL E3 ubiquitin-protein ligase ubr-1 ...1090.7     38.9     28     40GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0031624; F:ubiquitin conjugating enzyme binding; IPI:WormBase.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030163; P:protein catabolic process; IEA:InterPro.
12Q6ZT12    1888   UBR3_HUMAN E3 ubiquitin-protein ligase UBR3 O...2020.007     45.4     24     35GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0007608; P:sensory perception of smell; ISS:UniProtKB.::GO:0001967; P:suckling behavior; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
13Q5U430    1889   UBR3_MOUSE E3 ubiquitin-protein ligase UBR3 O...2020.008     45.1     24     35GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0042048; P:olfactory behavior; IMP:MGI.::GO:0007608; P:sensory perception of smell; IMP:UniProtKB.::GO:0001967; P:suckling behavior; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
14Q9BX97    442   PLVAP_HUMAN Plasmalemma vesicle-associated pr...1500.34     39.3     26     45GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
15Q8YZQ3    97   CLPS_NOSS1 ATP-dependent Clp protease adapter...681.1     35     29     56
GO:0030163; P:protein catabolic process; IEA:InterPro.
16P29334    373   LUXE_PHOLE Long-chain-fatty-acid--luciferin-c...986.2     35     28     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0047474; F:long-chain fatty acid luciferin component ligase activity; IEA:EC.
GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
17B0WC46    517   TRET1_CULQU Facilitated trehalose transporter...788.1     35     31     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0044459; C:plasma membrane part; ISS:UniProtKB.
GO:0015574; F:trehalose transmembrane transporter activity; ISS:UniProtKB.
18Q92824    1860   PCSK5_HUMAN Proprotein convertase subtilisin/...1279.1     35     28     41GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005615; C:extracellular space; ISS:BHF-UCL.::GO:0005796; C:Golgi lumen; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030141; C:secretory granule; ISS:BHF-UCL.
GO:0042277; F:peptide binding; ISS:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO:0009952; P:anterior/posterior pattern specification; IMP:BHF-UCL.::GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0042089; P:cytokine biosynthetic process; ISS:BHF-UCL.::GO:0007566; P:embryo implantation; ISS:BHF-UCL.::GO:0048566; P:embryonic digestive tract development; IMP:BHF-UCL.::GO:0048706; P:embryonic skeletal system development; IMP:BHF-UCL.::GO:0007507; P:heart development; ISS:BHF-UCL.::GO:0001822; P:kidney development; IMP:BHF-UCL.::GO:0035108; P:limb morphogenesis; ISS:BHF-UCL.::GO:0032455; P:nerve growth factor processing; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0002001; P:renin secretion into blood stream; IEP:BHF-UCL.::GO:0030323; P:respiratory tube development; ISS:BHF-UCL.::GO:0006465; P:signal peptide processing; IDA:HGNC.::GO:0019067; P:viral assembly, maturation, egress, and release; IEP:BHF-UCL.
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