Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR180C
Length:
345
Number of sequences:
5887
Description:
YGR180C RNR4 SGDID:S000003412, Chr VII from 856301-855264, Genome Release 64-1-1, reverse complement, Verified ORF, "Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P49723    345   RIR4_YEAST Ribonucleoside-diphosphate reducta...3450     713     100     100GO:0005634; C:nucleus; IDA:SGD.::GO:0005971; C:ribonucleoside-diphosphate reductase complex; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IMP:SGD.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0051188; P:cofactor biosynthetic process; IMP:SGD.::GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; IDA:SGD.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
2P09938    399   RIR2_YEAST Ribonucleoside-diphosphate reducta...3478e-136     399     54     74GO:0005634; C:nucleus; IDA:SGD.::GO:0005971; C:ribonucleoside-diphosphate reductase complex; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IDA:SGD.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; IDA:SGD.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
3P36603    391   RIR2_SCHPO Ribonucleoside-diphosphate reducta...3324e-121     361     53     72GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005971; C:ribonucleoside-diphosphate reductase complex; TAS:PomBase.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0009216; P:purine deoxyribonucleoside triphosphate biosynthetic process; IC:PomBase.::GO:0042278; P:purine nucleoside metabolic process; IC:PomBase.::GO:0009212; P:pyrimidine deoxyribonucleoside triphosphate biosynthetic process; IC:PomBase.::GO:0006213; P:pyrimidine nucleoside metabolic process; IC:PomBase.::GO:0090329; P:regulation of DNA-dependent DNA replication; TAS:PomBase.::GO:0007090; P:regulation of S phase of mitotic cell cycle; IC:PomBase.
4Q9C167    410   RIR2_NEUCR Ribonucleoside-diphosphate reducta...3411e-117     353     50     70
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
5P11157    390   RIR2_MOUSE Ribonucleoside-diphosphate reducta...3247e-109     330     49     69GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IDA:UniProtKB.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; IDA:UniProtKB.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0051290; P:protein heterotetramerization; IPI:UniProtKB.
6P07201    384   RIR2_SPISO Ribonucleoside-diphosphate reducta...3308e-109     329     49     68
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
7Q60561    386   RIR2_MESAU Ribonucleoside-diphosphate reducta...3139e-108     327     50     70GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ISS:UniProtKB.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; ISS:UniProtKB.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
8P79733    386   RIR2_DANRE Ribonucleoside-diphosphate reducta...3284e-107     325     48     68GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
9Q4KLN6    390   RIR2_RAT Ribonucleoside-diphosphate reductase...3287e-107     325     48     69GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005635; C:nuclear envelope; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ISS:UniProtKB.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; ISS:UniProtKB.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000278; P:mitotic cell cycle; IEP:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0006206; P:pyrimidine base metabolic process; IEP:RGD.
10P31350    389   RIR2_HUMAN Ribonucleoside-diphosphate reducta...3242e-106     324     48     68GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ISS:UniProtKB.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; ISS:UniProtKB.::GO:0006260; P:DNA replication; NAS:UniProtKB.::GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome.
11Q4R7Q7    389   RIR2_MACFA Ribonucleoside-diphosphate reducta...3248e-106     322     48     68GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ISS:UniProtKB.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009263; P:deoxyribonucleotide biosynthetic process; ISS:UniProtKB.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
12Q6PEE3    351   RIR2B_MOUSE Ribonucleoside-diphosphate reduct...3231e-104     317     47     70GO:0005739; C:mitochondrion; IC:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IDA:MGI.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IMP:MGI.::GO:0009263; P:deoxyribonucleotide biosynthetic process; IDA:MGI.::GO:0006281; P:DNA repair; IMP:MGI.::GO:0001822; P:kidney development; IMP:MGI.::GO:0006264; P:mitochondrial DNA replication; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0003014; P:renal system process; IMP:MGI.::GO:0006979; P:response to oxidative stress; IMP:MGI.
13Q7LG56    351   RIR2B_HUMAN Ribonucleoside-diphosphate reduct...3382e-104     317     46     69GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
14Q4R741    351   RIR2B_MACFA Ribonucleoside-diphosphate reduct...3232e-104     317     47     70GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
15O57175    319   RIR2_VACCA Ribonucleoside-diphosphate reducta...3093e-104     315     49     70
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
16Q5R9G0    351   RIR2B_PONAB Ribonucleoside-diphosphate reduct...3236e-104     316     47     70GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
17P11158    319   RIR2_VACCW Ribonucleoside-diphosphate reducta...3094e-103     313     49     70
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
18P20493    319   RIR2_VACCC Ribonucleoside-diphosphate reducta...3094e-103     313     49     70
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
19P29883    319   RIR2_VACCP Ribonucleoside-diphosphate reducta...3096e-103     312     49     70
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
20P48592    393   RIR2_DROME Ribonucleoside-diphosphate reducta...3076e-103     315     49     69GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase.::GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
21P33799    319   RIR2_VAR67 Ribonucleoside-diphosphate reducta...3096e-102     310     48     70
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
22Q8SRR2    325   RIR2_ENCCU Ribonucleoside-diphosphate reducta...3273e-99     303     47     66
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
23Q9DHU2    325   RIR2_YLDV Ribonucleoside-diphosphate reductas...3074e-98     300     47     68
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
24P50651    341   RIR2A_ARATH Ribonucleoside-diphosphate reduct...3371e-96     296     45     65GO:0005829; C:cytosol; IDA:TAIR.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IDA:TAIR.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006281; P:DNA repair; TAS:TAIR.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IMP:TAIR.::GO:0051726; P:regulation of cell cycle; IMP:TAIR.::GO:0009259; P:ribonucleotide metabolic process; TAS:TAIR.
25P42521    338   RIR2_DICDI Ribonucleoside-diphosphate reducta...3286e-96     295     46     66GO:0005634; C:nucleus; ISS:dictyBase.::GO:0005971; C:ribonucleoside-diphosphate reductase complex; ISS:dictyBase.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; ISS:dictyBase.::GO:0042493; P:response to drug; ISS:dictyBase.
26P42170    381   RIR2_CAEEL Ribonucleoside-diphosphate reducta...3302e-95     295     44     67
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0016477; P:cell migration; IMP:WormBase.::GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0030728; P:ovulation; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
27O15910    337   RIR2_TRYBB Ribonucleoside-diphosphate reducta...3301e-94     292     46     65
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
28P49730    329   RIR2_TOBAC Ribonucleoside-diphosphate reducta...3254e-94     290     45     66GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
29O46310    345   RIR2_LEIAM Ribonucleoside-diphosphate reducta...3268e-94     290     44     67
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
30Q6Y657    333   RIR2B_ARATH Putative ribonucleoside-diphospha...3092e-93     288     46     68GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
31P50650    349   RIR2_PLAF4 Ribonucleoside-diphosphate reducta...3225e-89     277     43     67
GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.::GO:0046914; F:transition metal ion binding; IEA:InterPro.
GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
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