Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR162W
Length:
952
Number of sequences:
5887
Description:
YGR162W TIF4631 SGDID:S000003394, Chr VII from 824059-826917, Genome Release 64-1-1, Verified ORF, "Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P39935    952   IF4F1_YEAST Eukaryotic initiation factor 4F s...9520     1964     100     100GO:0010494; C:cytoplasmic stress granule; IDA:SGD.::GO:0016281; C:eukaryotic translation initiation factor 4F complex; IMP:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005840; C:ribosome; TAS:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; TAS:SGD.
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0042273; P:ribosomal large subunit biogenesis; IMP:SGD.::GO:0016070; P:RNA metabolic process; IEA:InterPro.::GO:0034063; P:stress granule assembly; IMP:SGD.
2P39936    914   IF4F2_YEAST Eukaryotic initiation factor 4F s...5650     733     68     78GO:0010494; C:cytoplasmic stress granule; IDA:SGD.::GO:0016281; C:eukaryotic translation initiation factor 4F complex; IGI:SGD.::GO:0005840; C:ribosome; TAS:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; TAS:SGD.
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0016070; P:RNA metabolic process; IEA:InterPro.::GO:0034063; P:stress granule assembly; IMP:SGD.
3Q10475    1403   IF4G_SCHPO Eukaryotic translation initiation ...3531e-68     254     42     59GO:0005829; C:cytosol; IDA:PomBase.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0005198; F:structural molecule activity; TAS:PomBase.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0002183; P:cytoplasmic translational initiation; NAS:PomBase.::GO:0042273; P:ribosomal large subunit biogenesis; ISS:PomBase.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
4Q80XI3    1579   IF4G3_MOUSE Eukaryotic translation initiation...2961e-32     141     33     52
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0007128; P:meiotic prophase I; IMP:MGI.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI.::GO:0045727; P:positive regulation of translation; IMP:MGI.::GO:0016070; P:RNA metabolic process; IEA:InterPro.::GO:0007283; P:spermatogenesis; IMP:MGI.
5O43432    1585   IF4G3_HUMAN Eukaryotic translation initiation...2963e-32     139     33     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0016281; C:eukaryotic translation initiation factor 4F complex; TAS:ProtInc.
GO:0005488; F:binding; IEA:InterPro.::GO:0000339; F:RNA cap binding; TAS:ProtInc.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006446; P:regulation of translational initiation; TAS:ProtInc.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
6Q04637    1599   IF4G1_HUMAN Eukaryotic translation initiation...3101e-31     137     33     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0016281; C:eukaryotic translation initiation factor 4F complex; TAS:ProtInc.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003743; F:translation initiation factor activity; TAS:UniProtKB.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.::GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.::GO:0006446; P:regulation of translational initiation; IMP:UniProtKB.
7Q6NZJ6    1600   IF4G1_MOUSE Eukaryotic translation initiation...3102e-31     137     34     49GO:0005737; C:cytoplasm; IDA:MGI.
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
8Q76E23    1727   IF4G1_ARATH Eukaryotic translation initiation...4901e-26     121     27     43
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
9Q62448    906   IF4G2_MOUSE Eukaryotic translation initiation...3031e-21     104     29     51GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; IDA:UniProtKB.
GO:0006446; P:regulation of translational initiation; IDA:UniProtKB.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
10P79398    907   IF4G2_RABIT Eukaryotic translation initiation...3042e-21     104     29     51GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:UniProtKB.
GO:0003743; F:translation initiation factor activity; IDA:UniProtKB.
GO:0006446; P:regulation of translational initiation; IDA:UniProtKB.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
11Q03387    788   IF41_WHEAT Eukaryotic initiation factor iso-4...2942e-21     104     28     49
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
12Q5R7J9    907   IF4G2_PONAB Eukaryotic translation initiation...3042e-21     104     30     52GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:UniProtKB.
GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
13P78344    907   IF4G2_HUMAN Eukaryotic translation initiation...3042e-21     104     30     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; IDA:UniProtKB.
GO:0007050; P:cell cycle arrest; TAS:ProtInc.::GO:0008219; P:cell death; TAS:ProtInc.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0006446; P:regulation of translational initiation; IDA:UniProtKB.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
14Q95L46    907   IF4G2_BOVIN Eukaryotic translation initiation...3042e-21     104     30     52GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:UniProtKB.
GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
15P41110    1402   IF4G1_RABIT Eukaryotic translation initiation...3133e-20     100     29     46
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
16Q553R3    1377   IF4G_DICDI Eukaryotic translation initiation ...3352e-19     98.2     26     47GO:0016281; C:eukaryotic translation initiation factor 4F complex; ISS:dictyBase.
GO:0003743; F:translation initiation factor activity; ISS:dictyBase.
GO:0006446; P:regulation of translational initiation; ISS:dictyBase.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
17C7G046    2079   Y6969_DICDI von Willebrand factor A domain-co...2500.00000000002     72     27     48
GO:0005488; F:binding; IEA:InterPro.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
18Q5Z5Q3    711   C3H43_ORYSJ Zinc finger CCCH domain-containin...2010.00003     51.6     28     45
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
19Q8VE62    400   PAIP1_MOUSE Polyadenylate-binding protein-int...3020.00003     50.8     24     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016070; P:RNA metabolic process; IEA:InterPro.
20Q9H074    479   PAIP1_HUMAN Polyadenylate-binding protein-int...3050.0003     48.1     24     43GO:0005829; C:cytosol; TAS:Reactome.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003723; F:RNA binding; TAS:ProtInc.::GO:0008494; F:translation activator activity; IDA:UniProtKB.
GO:0048255; P:mRNA stabilization; TAS:UniProtKB.::GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.::GO:0006413; P:translational initiation; TAS:ProtInc.
21Q8SVP8    627   IF4G_ENCCU Probable eukaryotic translation in...590.1     40     39     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
22Q9BXK5    485   B2L13_HUMAN Bcl-2-like protein 13 OS=Homo sap...1010.46     37.7     26     47GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; NAS:UniProtKB.
GO:0006917; P:induction of apoptosis; NAS:UniProtKB.
23C4V8K5    598   IF4G_NOSCE Probable eukaryotic translation in...2174.9     34.7     22     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0016070; P:RNA metabolic process; IEA:InterPro.
24O70437    552   SMAD4_RAT Mothers against decapentaplegic hom...655.5     34.3     31     45
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
25P97471    551   SMAD4_MOUSE Mothers against decapentaplegic h...655.5     34.3     31     45
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0005518; F:collagen binding; IPI:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
GO:0008283; P:cell proliferation; IMP:MGI.::GO:0048589; P:developmental growth; IMP:MGI.::GO:0007492; P:endoderm development; IMP:MGI.::GO:0048859; P:formation of anatomical boundary; IMP:MGI.::GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0007498; P:mesoderm development; IMP:MGI.::GO:0072133; P:metanephric mesenchyme morphogenesis; IMP:UniProtKB.::GO:0060548; P:negative regulation of cell death; IMP:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.::GO:0072134; P:nephrogenic mesenchyme morphogenesis; IMP:UniProtKB.::GO:0014033; P:neural crest cell differentiation; IMP:MGI.::GO:0048663; P:neuron fate commitment; IMP:MGI.::GO:0060021; P:palate development; IMP:BHF-UCL.::GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IMP:BHF-UCL.::GO:0060391; P:positive regulation of SMAD protein import into nucleus; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0051098; P:regulation of binding; IDA:MGI.::GO:0051797; P:regulation of hair follicle development; IMP:MGI.::GO:0048733; P:sebaceous gland development; IMP:MGI.::GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
26Q1HE26    553   SMAD4_BOVIN Mothers against decapentaplegic h...656.8     34.3     31     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005667; C:transcription factor complex; IEA:InterPro.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
27O88799    5376   ZAN_MOUSE Zonadhesin OS=Mus musculus (Mouse)....2787.8     34.3     24     35GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
28B0KL24    626   THIC_PSEPG Phosphomethylpyrimidine synthase O...708.2     33.9     33     46
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
29Q13485    552   SMAD4_HUMAN Mothers against decapentaplegic h...658.7     33.9     31     43GO:0032444; C:activin responsive factor complex; IDA:BHF-UCL.::GO:0005813; C:centrosome; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0071141; C:SMAD protein complex; IDA:UniProtKB.
GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:UniProtKB.::GO:0070411; F:I-SMAD binding; IPI:BHF-UCL.::GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.::GO:0070412; F:R-SMAD binding; IPI:BHF-UCL.::GO:0030616; F:transforming growth factor beta receptor, common-partner cytoplasmic mediator activity; IDA:BHF-UCL.
GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL.::GO:0042177; P:negative regulation of protein catabolic process; IMP:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0060021; P:palate development; ISS:BHF-UCL.::GO:0030513; P:positive regulation of BMP signaling pathway; IMP:BHF-UCL.::GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISS:BHF-UCL.::GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:BHF-UCL.::GO:0060391; P:positive regulation of SMAD protein import into nucleus; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.::GO:0032909; P:regulation of transforming growth factor beta2 production; IMP:BHF-UCL.::GO:0001666; P:response to hypoxia; IMP:BHF-UCL.::GO:0071559; P:response to transforming growth factor beta stimulus; IDA:UniProtKB.::GO:0007183; P:SMAD protein complex assembly; IDA:BHF-UCL.::GO:0060395; P:SMAD protein signal transduction; IDA:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.
30Q008X6    6872   R1AB_WBV24 Replicase polyprotein 1ab OS=White...19410     33.9     21     36GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0032774; P:RNA biosynthetic process; IEA:UniProtKB-KW.
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