UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YGR136W

Length:

241

Number of sequences:

5887

Description:

YGR136W LSB1 SGDID:S000003368, Chr VII from 762428-763153, Genome Release 64-1-1, Verified ORF, "Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	Q8R1B0	408	STAC2_MOUSE SH3 and cysteine-rich domain-cont...	52	0.00000002	57.8	44	75
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
62	Q9Y5K6	639	CD2AP_HUMAN CD2-associated protein OS=Homo sa...	53	0.0007	43.9	34	60	GO:0005737; C:cytoplasm; IDA:HPA.::GO:0031941; C:filamentous actin; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0001726; C:ruffle; IDA:UniProtKB.
									GO:0017124; F:SH3 domain binding; IPI:UniProtKB.::GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
									GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006461; P:protein complex assembly; TAS:ProtInc.::GO:0007165; P:signal transduction; NAS:ProtInc.::GO:0006930; P:substrate-dependent cell migration, cell extension; TAS:ProtInc.
63	Q6ZMT1	411	STAC2_HUMAN SH3 and cysteine-rich domain-cont...	52	0.00000002	57.4	44	75
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
64	Q5A895	498	HSE1_CANAL Class E vacuolar protein-sorting m...	58	0.00000002	57.8	47	62	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
65	A0JNJ1	403	STAC_BOVIN SH3 and cysteine-rich domain-conta...	67	0.00000003	57	42	63	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
66	O88811	523	STAM2_MOUSE Signal transducing adapter molecu...	50	0.00000003	57	44	72	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
67	A3LXQ8	475	HSE1_PICST Class E vacuolar protein-sorting m...	59	0.00000004	56.6	39	63	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
68	Q8AXV0	367	SH3G1_CHICK Endophilin-A2 OS=Gallus gallus (C...	51	0.00000004	56.6	47	63	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
69	P42683	508	LCK_CHICK Proto-oncogene tyrosine-protein kin...	78	0.00000005	56.6	41	63	GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
									GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB.
70	O94478	420	MU137_SCHPO Meiotically up-regulated gene 137...	158	0.00000005	56.2	31	43	GO:0032153; C:cell division site; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0007126; P:meiosis; IEP:PomBase.
71	P97306	403	STAC_MOUSE SH3 and cysteine-rich domain-conta...	67	0.00000005	56.2	40	63	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0034605; P:cellular response to heat; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
72	Q99469	402	STAC_HUMAN SH3 and cysteine-rich domain-conta...	52	0.00000005	56.2	48	71	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0035556; P:intracellular signal transduction; IEA:InterPro.
73	Q3U1V8	1077	M3K9_MOUSE Mitogen-activated protein kinase k...	68	0.0000001	55.8	40	65
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
									GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
74	Q4P5J4	593	HSE1_USTMA Class E vacuolar protein-sorting m...	51	0.0000001	55.5	43	65	GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
75	P80192	1104	M3K9_HUMAN Mitogen-activated protein kinase k...	68	0.0000001	55.5	40	65
									GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004706; F:JUN kinase kinase kinase activity; ISS:UniProtKB.::GO:0004708; F:MAP kinase kinase activity; NAS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
									GO:0007257; P:activation of JUN kinase activity; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
76	P43603	459	LSB3_YEAST LAS seventeen-binding protein 3 OS...	51	0.0000001	55.1	47	65	GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
									GO:0005515; F:protein binding; IPI:IntAct.
									GO:0051666; P:actin cortical patch localization; IMP:SGD.
77	A7A261	459	LSB3_YEAS7 LAS seventeen-binding protein 3 OS...	51	0.0000001	55.1	47	65	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
78	Q8AXU9	353	SH3G3_CHICK Endophilin-A3 OS=Gallus gallus (C...	51	0.0000002	54.7	45	63	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
79	P19878	526	NCF2_HUMAN Neutrophil cytosol factor 2 OS=Hom...	54	6.5	31.6	28	52	GO:0043020; C:NADPH oxidase complex; TAS:BHF-UCL.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0032010; C:phagolysosome; TAS:Reactome.
									GO:0009055; F:electron carrier activity; TAS:UniProtKB.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
									GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0006968; P:cellular defense response; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:BHF-UCL.::GO:0045730; P:respiratory burst; TAS:BHF-UCL.::GO:0042554; P:superoxide anion generation; TAS:BHF-UCL.
80	Q9NZM3	1697	ITSN2_HUMAN Intersectin-2 OS=Homo sapiens (Hu...	50	0.59	35	36	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
81	Q9Z0R6	1659	ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo...	50	1.9	33.5	34	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
82	Q5XHY7	523	STAM2_RAT Signal transducing adapter molecule...	50	0.0000003	53.9	42	70	GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0006886; P:intracellular protein transport; IEA:InterPro.
83	P97369	339	NCF4_MOUSE Neutrophil cytosol factor 4 OS=Mus...	65	0.0000005	53.1	43	54	GO:0005737; C:cytoplasm; IDA:MGI.
									GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.
									GO:0007154; P:cell communication; IEA:InterPro.
84	Q9P7E8	857	APP1_SCHPO Protein app1 OS=Schizosaccharomyce...	50	2	33.5	32	66	GO:0030479; C:actin cortical patch; IDA:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.
									GO:0003779; F:actin binding; IEA:InterPro.
									GO:0030036; P:actin cytoskeleton organization; IC:PomBase.
85	Q69ZI1	892	SH3R1_MOUSE E3 ubiquitin-protein ligase SH3RF...	55	0.06	38.1	31	55	GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005078; F:MAP-kinase scaffold activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0046328; P:regulation of JNK cascade; IDA:MGI.
86	Q9URW6	430	YIE2_SCHPO SH3 domain-containing protein PJ69...	52	0.0000005	53.1	46	63	GO:0030479; C:actin cortical patch; ISS:PomBase.
									GO:0007015; P:actin filament organization; ISS:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.
87	Q62420	352	SH3G2_MOUSE Endophilin-A1 OS=Mus musculus (Mo...	51	0.0000005	53.1	43	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
									GO:0002090; P:regulation of receptor internalization; IDA:MGI.::GO:0048488; P:synaptic vesicle endocytosis; IGI:MGI.
88	O35179	352	SH3G2_RAT Endophilin-A1 OS=Rattus norvegicus ...	51	0.0000006	53.1	43	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
									GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
89	Q99962	352	SH3G2_HUMAN Endophilin-A1 OS=Homo sapiens (Hu...	51	0.0000007	52.8	43	59	GO:0005829; C:cytosol; TAS:Reactome.::GO:0000139; C:Golgi membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
									GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
									GO:0007411; P:axon guidance; TAS:Reactome.::GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
90	Q8AXV1	353	SH3G2_CHICK Endophilin-A1 OS=Gallus gallus (C...	50	0.0000007	52.8	44	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
91	Q8R550	709	SH3K1_MOUSE SH3 domain-containing kinase-bind...	54	0.0001	46.2	35	63	GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
									GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.

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