Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR136W
Length:
241
Number of sequences:
5887
Description:
YGR136W LSB1 SGDID:S000003368, Chr VII from 762428-763153, Genome Release 64-1-1, Verified ORF, "Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
361Q9WV48    2167   SHAN1_RAT SH3 and multiple ankyrin repeat dom...550.013     40.4     31     62GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; ISS:BHF-UCL.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL.::GO:0045211; C:postsynaptic membrane; IDA:RGD.
GO:0071532; F:ankyrin repeat binding; IPI:BHF-UCL.::GO:0030160; F:GKAP/Homer scaffold activity; IDA:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:RGD.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0097110; F:scaffold protein binding; IPI:BHF-UCL.::GO:0017124; F:SH3 domain binding; IPI:BHF-UCL.::GO:0031877; F:somatostatin receptor binding; IPI:UniProtKB.
GO:0008306; P:associative learning; ISS:BHF-UCL.::GO:0007016; P:cytoskeletal anchoring at plasma membrane; NAS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:BHF-UCL.::GO:0007616; P:long-term memory; ISS:BHF-UCL.::GO:0050885; P:neuromuscular process controlling balance; ISS:BHF-UCL.::GO:0060999; P:positive regulation of dendritic spine development; IDA:UniProtKB.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:0006461; P:protein complex assembly; IDA:BHF-UCL.::GO:0035418; P:protein localization to synapse; ISS:BHF-UCL.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.::GO:0060074; P:synapse maturation; IDA:UniProtKB.
362D3YZU1    2167   SHAN1_MOUSE SH3 and multiple ankyrin repeat d...550.013     40.4     31     62GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; IDA:BHF-UCL.::GO:0014069; C:postsynaptic density; IDA:BHF-UCL.::GO:0045211; C:postsynaptic membrane; IDA:MGI.::GO:0019717; C:synaptosome; IDA:BHF-UCL.
GO:0071532; F:ankyrin repeat binding; ISS:BHF-UCL.::GO:0030160; F:GKAP/Homer scaffold activity; IMP:BHF-UCL.::GO:0042802; F:identical protein binding; ISS:BHF-UCL.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:BHF-UCL.::GO:0097110; F:scaffold protein binding; ISS:BHF-UCL.::GO:0017124; F:SH3 domain binding; ISS:BHF-UCL.
GO:0008306; P:associative learning; IMP:BHF-UCL.::GO:0060997; P:dendritic spine morphogenesis; IMP:BHF-UCL.::GO:0046959; P:habituation; IMP:BHF-UCL.::GO:0007616; P:long-term memory; IMP:BHF-UCL.::GO:0032232; P:negative regulation of actin filament bundle assembly; IDA:MGI.::GO:0050885; P:neuromuscular process controlling balance; IMP:BHF-UCL.::GO:0042048; P:olfactory behavior; IMP:BHF-UCL.::GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.::GO:0006461; P:protein complex assembly; ISS:BHF-UCL.::GO:0035418; P:protein localization to synapse; IMP:BHF-UCL.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:BHF-UCL.::GO:0060013; P:righting reflex; IMP:BHF-UCL.::GO:0035176; P:social behavior; IMP:BHF-UCL.::GO:0071625; P:vocalization behavior; IMP:BHF-UCL.
363Q92608    1830   DOCK2_HUMAN Dedicator of cytokinesis protein ...610.013     40.4     36     56GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0042608; F:T cell receptor binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
364Q92882    214   OSTF1_HUMAN Osteoclast-stimulating factor 1 O...480.015     39.3     35     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0001503; P:ossification; TAS:ProtInc.::GO:0007165; P:signal transduction; TAS:ProtInc.
365Q13625    1128   ASPP2_HUMAN Apoptosis-stimulating of p53 prot...530.017     39.7     32     57GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0051059; F:NF-kappaB binding; IPI:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IDA:UniProtKB.::GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.::GO:0007165; P:signal transduction; TAS:ProtInc.
366Q8N1I0    1966   DOCK4_HUMAN Dedicator of cytokinesis protein ...560.018     40     43     57GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IDA:UniProtKB.::GO:0032420; C:stereocilium; ISS:HGNC.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0030165; F:PDZ domain binding; IPI:HGNC.::GO:0030675; F:Rac GTPase activator activity; IDA:HGNC.::GO:0048365; F:Rac GTPase binding; IDA:HGNC.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0060326; P:cell chemotaxis; IMP:UniProtKB.
367Q8MJ49    214   OSTF1_PIG Osteoclast-stimulating factor 1 OS=...480.018     38.9     35     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
368P19174    1290   PLCG1_HUMAN 1-phosphatidylinositol 4,5-bispho...520.019     39.7     38     63GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; NAS:UniProtKB.
GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0045766; P:positive regulation of angiogenesis; IDA:DFLAT.::GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:DFLAT.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
369P43069    1333   CDC25_CANAL Cell division control protein 25 ...890.019     39.7     30     43GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:CGD.
GO:0019933; P:cAMP-mediated signaling; IMP:CGD.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0071333; P:cellular response to glucose stimulus; IMP:CGD.::GO:0030447; P:filamentous growth; IMP:CGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IGI:CGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
370Q95KR7    509   LCK_SAISC Proto-oncogene tyrosine-protein kin...740.02     39.3     31     55GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB.
371Q02779    954   M3K10_HUMAN Mitogen-activated protein kinase ...540.02     39.7     41     72GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043425; F:bHLH transcription factor binding; IPI:UniProtKB.::GO:0004706; F:JUN kinase kinase kinase activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO:0007257; P:activation of JUN kinase activity; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; TAS:ProtInc.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0046330; P:positive regulation of JNK cascade; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0007224; P:smoothened signaling pathway; IMP:UniProtKB.
372P59764    1978   DOCK4_MOUSE Dedicator of cytokinesis protein ...560.021     39.7     43     57GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; ISS:UniProtKB.::GO:0032420; C:stereocilium; IDA:HGNC.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
373A8MVU1    366   NCF1C_HUMAN Putative neutrophil cytosol facto...542.3     32.7     28     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0016175; F:superoxide-generating NADPH oxidase activity; IEA:InterPro.
GO:0007154; P:cell communication; IEA:InterPro.
374Q8C3J5    1828   DOCK2_MOUSE Dedicator of cytokinesis protein ...610.022     39.7     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IMP:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0042608; F:T cell receptor binding; ISS:UniProtKB.
GO:0046633; P:alpha-beta T cell proliferation; IMP:MGI.::GO:0006935; P:chemotaxis; IMP:MGI.::GO:0007010; P:cytoskeleton organization; IDA:MGI.::GO:0001768; P:establishment of T cell polarity; IMP:MGI.::GO:0001771; P:immunological synapse formation; IMP:MGI.::GO:0001766; P:membrane raft polarization; IMP:MGI.::GO:0045060; P:negative thymic T cell selection; IMP:MGI.::GO:0035022; P:positive regulation of Rac protein signal transduction; IC:MGI.::GO:0045059; P:positive thymic T cell selection; IMP:MGI.
375P25911    512   LYN_MOUSE Tyrosine-protein kinase Lyn OS=Mus ...630.022     39.3     40     59GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005128; F:erythropoietin receptor binding; TAS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0017124; F:SH3 domain binding; IPI:MGI.
GO:0001782; P:B cell homeostasis; IMP:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; IDA:MGI.::GO:0097028; P:dendritic cell differentiation; IMP:UniProtKB.::GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; IMP:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IMP:UniProtKB.::GO:0042541; P:hemoglobin biosynthetic process; TAS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IDA:MGI.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IMP:UniProtKB.::GO:0030889; P:negative regulation of B cell proliferation; IMP:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; IMP:UniProtKB.::GO:0002762; P:negative regulation of myeloid leukocyte differentiation; IMP:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; IMP:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IMP:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IMP:UniProtKB.::GO:0031175; P:neuron projection development; IMP:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0002576; P:platelet degranulation; IMP:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; IMP:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0002902; P:regulation of B cell apoptotic process; IMP:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; IMP:UniProtKB.::GO:0050707; P:regulation of cytokine secretion; IMP:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; IMP:UniProtKB.::GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; IMP:UniProtKB.::GO:0002513; P:tolerance induction to self antigen; IMP:UniProtKB.
376O00160    1098   MYO1F_HUMAN Unconventional myosin-If OS=Homo ...510.024     39.3     31     57GO:0016461; C:unconventional myosin complex; NAS:UniProtKB.
GO:0003779; F:actin binding; NAS:UniProtKB.::GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0003774; F:motor activity; IEA:InterPro.
377Q7SDM3    1235   MYO1_NEUCR Myosin-1 OS=1257 / FGSC 987). GN=m...500.025     39.3     34     60GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
378Q07014    512   LYN_RAT Tyrosine-protein kinase Lyn OS=Rattus...540.029     38.9     39     63GO:0034666; C:alpha2-beta1 integrin complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0030061; C:mitochondrial crista; IDA:RGD.::GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043208; F:glycosphingolipid binding; IPI:RGD.::GO:0005178; F:integrin binding; IDA:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0051219; F:phosphoprotein binding; IPI:RGD.::GO:0005161; F:platelet-derived growth factor receptor binding; IPI:RGD.::GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD.
GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0034605; P:cellular response to heat; IEP:RGD.::GO:0050663; P:cytokine secretion; IMP:RGD.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0002553; P:histamine secretion by mast cell; IMP:RGD.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; IEP:RGD.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0060369; P:positive regulation of Fc receptor mediated stimulatory signaling pathway; IMP:RGD.::GO:0060252; P:positive regulation of glial cell proliferation; IDA:RGD.::GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IMP:RGD.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IMP:RGD.::GO:0043200; P:response to amino acid stimulus; IEP:RGD.::GO:0048678; P:response to axon injury; IEP:RGD.::GO:0009743; P:response to carbohydrate stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032868; P:response to insulin stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0006991; P:response to sterol depletion; IEP:RGD.::GO:0009636; P:response to toxin; IEP:RGD.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB.
379O76041    1014   NEBL_HUMAN Nebulette OS=Homo sapiens (Human)....630.031     38.9     32     54GO:0001725; C:stress fiber; IDA:UniProtKB.::GO:0030018; C:Z disc; IDA:UniProtKB.
GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0031005; F:filamin binding; IPI:UniProtKB.::GO:0008307; F:structural constituent of muscle; NAS:UniProtKB.::GO:0005523; F:tropomyosin binding; IPI:UniProtKB.
GO:0071691; P:cardiac muscle thin filament assembly; IMP:UniProtKB.
380Q8IZD9    2030   DOCK3_HUMAN Dedicator of cytokinesis protein ...580.033     38.9     40     53GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
381E7RAI2    282   SHO1_PICAD High osmolarity signaling protein ...540.035     38.5     37     65GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0006950; P:response to stress; IEA:UniProtKB-KW.
382Q811P8    2089   RHG32_MOUSE Rho GTPase-activating protein 32 ...480.035     38.9     31     63GO:0015629; C:actin cytoskeleton; IDA:MGI.::GO:0005938; C:cell cortex; IDA:MGI.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.
383Q8MJ50    214   OSTF1_BOVIN Osteoclast-stimulating factor 1 O...480.037     38.1     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
384A7KAX9    2087   RHG32_HUMAN Rho GTPase-activating protein 32 ...480.037     38.9     31     63GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.::GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
385Q96JP2    1530   MY15B_HUMAN Putative unconventional myosin-XV...560.037     38.9     36     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:InterPro.::GO:0003774; F:motor activity; IEA:InterPro.
386Q09014    390   NCF1_MOUSE Neutrophil cytosol factor 1 OS=Mus...470.9     34.3     28     60GO:0005829; C:cytosol; TAS:MGI.
GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:MGI.::GO:0016175; F:superoxide-generating NADPH oxidase activity; IDA:MGI.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0006968; P:cellular defense response; IMP:MGI.::GO:0050665; P:hydrogen peroxide biosynthetic process; IMP:MGI.::GO:0006954; P:inflammatory response; IMP:MGI.::GO:0006691; P:leukotriene metabolic process; IMP:MGI.::GO:0045986; P:negative regulation of smooth muscle contraction; IMP:MGI.::GO:0070947; P:neutrophil mediated killing of fungus; IMP:MGI.::GO:0070946; P:neutrophil mediated killing of gram-positive bacterium; IMP:MGI.::GO:0006612; P:protein targeting to membrane; ISS:UniProtKB.::GO:0002679; P:respiratory burst involved in defense response; IMP:MGI.::GO:0001878; P:response to yeast; IMP:MGI.::GO:0042554; P:superoxide anion generation; IMP:MGI.
387P0CF33    103   SD25N_YEAST Truncated guanine nucleotide exch...750.039     36.6     29     43
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
388P35991    659   BTK_MOUSE Tyrosine-protein kinase BTK OS=Mus ...540.043     38.5     35     57GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048469; P:cell maturation; IMP:MGI.::GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IMP:MGI.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
389Q1KKZ1    329   SKAP2_TAKRU Src kinase-associated phosphoprot...640.047     38.1     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
390Q5PXS1    509   LCK_AOTNA Tyrosine-protein kinase Lck OS=Aotu...740.047     38.1     30     57GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB.
391O77774    392   NCF1_BOVIN Neutrophil cytosol factor 1 OS=Bos...560.79     34.3     29     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0006612; P:protein targeting to membrane; ISS:UniProtKB.
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