Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR132C
Length:
287
Number of sequences:
5887
Description:
YGR132C PHB1 SGDID:S000003364, Chr VII from 756452-755589, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P40961    287   PHB1_YEAST Prohibitin-1 OS=Saccharomyces cere...2870     580     100     100GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0007007; P:inner mitochondrial membrane organization; IMP:SGD.::GO:0000001; P:mitochondrion inheritance; IMP:SGD.::GO:0070584; P:mitochondrion morphogenesis; IMP:SGD.::GO:0045861; P:negative regulation of proteolysis; IPI:SGD.::GO:0006457; P:protein folding; IPI:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.
2Q9P7H3    282   PHB1_SCHPO Prohibitin-1 OS=Schizosaccharomyce...2822e-138     399     69     84GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
GO:0007007; P:inner mitochondrial membrane organization; ISS:PomBase.::GO:0000001; P:mitochondrion inheritance; ISS:PomBase.::GO:0006457; P:protein folding; ISS:PomBase.
3P84173    272   PHB_CHICK Prohibitin OS=Gallus gallus (Chicke...2641e-106     317     55     78GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
4P24156    276   L2CC_DROME Protein l(2)37Cc OS=Drosophila mel...2643e-106     317     55     78GO:0005811; C:lipid particle; IDA:FlyBase.::GO:0016020; C:membrane; IEA:InterPro.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.
GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
5Q54GI9    271   PHB1_DICDI Prohibitin-1, mitochondrial OS=Dic...2586e-106     316     56     79GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
6P67779    272   PHB_RAT Prohibitin OS=Rattus norvegicus (Rat)...2642e-105     315     55     78GO:0031315; C:extrinsic to mitochondrial outer membrane; IDA:RGD.::GO:0030061; C:mitochondrial crista; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0001552; P:ovarian follicle atresia; IEP:RGD.::GO:0001541; P:ovarian follicle development; IEP:RGD.::GO:0034097; P:response to cytokine stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.::GO:0006950; P:response to stress; IEP:RGD.
7P67778    272   PHB_MOUSE Prohibitin OS=Mus musculus (Mouse)....2642e-105     315     55     78GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
GO:0071897; P:DNA biosynthetic process; IMP:MGI.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
8P35232    272   PHB_HUMAN Prohibitin OS=Homo sapiens (Human)....2646e-105     313     54     78GO:0005887; C:integral to plasma membrane; IDA:HGNC.::GO:0005743; C:mitochondrial inner membrane; TAS:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO:0071354; P:cellular response to interleukin-6; IDA:BHF-UCL.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0016575; P:histone deacetylation; IDA:UniProtKB.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL.::GO:2000323; P:negative regulation of glucocorticoid receptor signaling pathway; IDA:BHF-UCL.::GO:0010944; P:negative regulation of transcription by competitive promoter binding; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL.::GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
9Q3T165    272   PHB_BOVIN Prohibitin OS=Bos taurus (Bovine). ...2646e-105     313     54     78GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
10Q9BKU4    275   PHB1_CAEEL Mitochondrial prohibitin complex p...2646e-99     298     56     78GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0030421; P:defecation; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0070584; P:mitochondrion morphogenesis; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0002082; P:regulation of oxidative phosphorylation; IMP:WormBase.::GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.::GO:0006979; P:response to oxidative stress; IMP:WormBase.::GO:0007283; P:spermatogenesis; IMP:WormBase.
11P50085    310   PHB2_YEAST Prohibitin-2 OS=Saccharomyces cere...2415e-97     294     59     79GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0000001; P:mitochondrion inheritance; IMP:SGD.::GO:0045861; P:negative regulation of proteolysis; IPI:SGD.::GO:0006457; P:protein folding; IDA:SGD.::GO:0001302; P:replicative cell aging; IMP:SGD.
12Q54Q31    293   PHB2_DICDI Prohibitin-2 OS=Dictyostelium disc...2387e-94     286     57     80GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
13Q2HJ97    299   PHB2_BOVIN Prohibitin-2 OS=Bos taurus (Bovine...2551e-91     280     51     78GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
14Q5XIH7    299   PHB2_RAT Prohibitin-2 OS=Rattus norvegicus (R...2559e-91     278     51     78GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
15O35129    299   PHB2_MOUSE Prohibitin-2 OS=Mus musculus (Mous...2551e-90     278     51     78GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0060749; P:mammary gland alveolus development; IMP:MGI.::GO:0060744; P:mammary gland branching involved in thelarche; IMP:MGI.::GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IMP:MGI.::GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
16Q99623    299   PHB2_HUMAN Prohibitin-2 OS=Homo sapiens (Huma...2551e-90     278     51     78GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0030331; F:estrogen receptor binding; NAS:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
17A9UMS3    301   PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis...2511e-90     278     54     76GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
18Q5RB19    299   PHB2_PONAB Prohibitin-2 OS=Pongo abelii (Suma...2507e-90     276     52     78GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
19O94550    288   PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyce...2391e-88     272     54     75GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
GO:0006457; P:protein folding; ISS:PomBase.
20Q5ZMN3    301   PHB2_CHICK Prohibitin-2 OS=Gallus gallus (Chi...2444e-87     269     51     79GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
21P50093    294   PHB2_CAEEL Mitochondrial prohibitin complex p...2373e-77     243     49     72GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0030421; P:defecation; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0070584; P:mitochondrion morphogenesis; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0002082; P:regulation of oxidative phosphorylation; IMP:WormBase.::GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.::GO:0006979; P:response to oxidative stress; IMP:WormBase.::GO:0007283; P:spermatogenesis; IMP:WormBase.
22P86220    87   PHB_MESAU Prohibitin OS=Mesocricetus auratus ...1160.00000000000001     72     41     53GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
23O28852    249   Y1420_ARCFU Uncharacterized protein AF_1420 O...2400.00000000001     66.2     28     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
24Q9V0Y1    268   Y658_PYRAB Uncharacterized protein PYRAB06580...2360.000007     50.1     28     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0016020; C:membrane; IEA:InterPro.
25P44545    295   HFLC_HAEIN Protein HflC OS=Haemophilus influe...2940.00002     48.9     26     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
26O59180    266   Y1511_PYRHO Uncharacterized protein PH1511 OS...2360.00002     48.5     28     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
27Q5UP73    303   YR614_MIMIV Putative band 7 family protein R6...2470.00005     47.8     22     46GO:0016020; C:membrane; IEA:InterPro.
28Q58237    199   Y827_METJA Uncharacterized protein MJ0827 OS=...1660.001     42.7     25     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
29O26788    318   Y692_METTH Uncharacterized protein MTH_692 OS...1950.004     41.6     22     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
30P0AA56    305   QMCA_SHIFL Protein QmcA OS=Shigella flexneri....1070.006     41.2     26     54GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
31P0AA53    305   QMCA_ECOLI Protein QmcA OS=Escherichia coli (...1070.006     41.2     26     54GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
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