UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YGR095C

Length:

223

Number of sequences:

5887

Description:

YGR095C RRP46 SGDID:S000003327, Chr VII from 676342-675671, Genome Release 64-1-1, reverse complement, Verified ORF, "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P53256	223	RRP46_YEAST Exosome complex component RRP46 O...	223	1e-159	447	100	100	GO:0000177; C:cytoplasmic exosome (RNase complex); IDA:SGD.::GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0070651; P:nonfunctional rRNA decay; IC:SGD.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IMP:SGD.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:SGD.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IDA:SGD.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IC:SGD.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IC:SGD.::GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IC:SGD.
2	O42894	226	RRP46_SCHPO Exosome complex component rrp46 O...	212	1e-22	96.7	32	52	GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0000176; C:nuclear exosome (RNase complex); ISS:PomBase.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0000175; F:3'-5'-exoribonuclease activity; ISS:PomBase.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:PomBase.::GO:0070651; P:nonfunctional rRNA decay; ISS:PomBase.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; ISS:PomBase.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; ISS:PomBase.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; ISS:PomBase.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISS:PomBase.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISS:PomBase.
3	Q9NQT4	235	EXOS5_HUMAN Exosome complex component RRP46 O...	185	6e-19	86.3	30	53	GO:0005829; C:cytosol; TAS:Reactome.::GO:0000178; C:exosome (RNase complex); IDA:UniProtKB.::GO:0005730; C:nucleolus; NAS:UniProtKB.::GO:0035327; C:transcriptionally active chromatin; IMP:UniProtKB.
									GO:0000175; F:3'-5'-exoribonuclease activity; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0051607; P:defense response to virus; IMP:MGI.::GO:0045006; P:DNA deamination; IDA:UniProtKB.::GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; IMP:UniProtKB.::GO:0006364; P:rRNA processing; NAS:UniProtKB.
4	Q9CRA8	235	EXOS5_MOUSE Exosome complex component RRP46 O...	161	3e-18	84	32	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
5	Q84T68	238	EXOS5_ORYSJ Exosome complex exonuclease RRP46...	218	0.0000000003	61.2	26	43	GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0004536; F:deoxyribonuclease activity; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:UniProtKB.::GO:0004540; F:ribonuclease activity; IDA:UniProtKB.::GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
6	A2BKC0	255	ECX1_HYPBU Probable exosome complex exonuclea...	223	0.0000000009	60.1	26	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
7	O29757	258	ECX1_ARCFU Probable exosome complex exonuclea...	221	0.000000003	58.9	24	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
8	Q9YC03	246	ECX1_AERPE Probable exosome complex exonuclea...	155	0.00000001	57.4	28	49	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
9	Q975G8	243	ECX1_SULTO Probable exosome complex exonuclea...	221	0.0000001	53.9	26	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
10	A8WQQ5	240	EXOS4_CAEBR Putative exosome complex componen...	165	0.0000002	53.5	27	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
11	Q5JIR6	249	ECX1_PYRKO Probable exosome complex exonuclea...	141	0.0000002	53.5	30	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
12	Q9NPD3	245	EXOS4_HUMAN Exosome complex component RRP41 O...	226	0.0000003	52.8	23	42	GO:0005829; C:cytosol; TAS:Reactome.::GO:0000178; C:exosome (RNase complex); IDA:UniProtKB.::GO:0005730; C:nucleolus; NAS:UniProtKB.::GO:0035327; C:transcriptionally active chromatin; IMP:UniProtKB.
									GO:0000175; F:3'-5'-exoribonuclease activity; NAS:UniProtKB.::GO:0017091; F:AU-rich element binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0051607; P:defense response to virus; IMP:MGI.::GO:0045006; P:DNA deamination; IDA:UniProtKB.::GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome.::GO:0071044; P:histone mRNA catabolic process; IMP:UniProtKB.::GO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB.::GO:0071028; P:nuclear mRNA surveillance; IMP:UniProtKB.::GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
13	Q9UXC2	248	ECX1_SULSO Probable exosome complex exonuclea...	156	0.000001	51.6	30	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
14	Q7YRA3	245	EXOS4_BOVIN Exosome complex component RRP41 O...	226	0.000001	51.2	22	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
									GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB.
15	Q8TYC1	239	ECX1_METKA Probable exosome complex exonuclea...	228	0.000002	50.4	23	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
16	B1Y978	246	ECX1_THENV Probable exosome complex exonuclea...	235	0.000003	50.4	23	40	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
17	Q8PTT8	493	ECX1_METMA Probable exosome complex exonuclea...	213	0.000007	49.7	24	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
18	B6YSI2	249	ECX1_THEON Probable exosome complex exonuclea...	161	0.000007	49.3	27	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
19	Q17533	240	EXOS4_CAEEL Putative exosome complex componen...	161	0.000007	48.9	23	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
20	C5A2B9	249	ECX1_THEGJ Probable exosome complex exonuclea...	142	0.00001	48.5	27	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
21	Q6P0I8	271	EXOS6_DANRE Exosome complex component MTR3 OS...	228	0.00001	48.9	25	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
22	Q921I9	245	EXOS4_MOUSE Exosome complex component RRP41 O...	226	0.00001	48.1	22	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0005515; F:protein binding; IPI:MGI.
									GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB.
23	P46948	246	RRP41_YEAST Exosome complex component SKI6 OS...	140	0.00002	48.1	29	43	GO:0000177; C:cytoplasmic exosome (RNase complex); IDA:SGD.::GO:0000176; C:nuclear exosome (RNase complex); IDA:SGD.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0070651; P:nonfunctional rRNA decay; IC:SGD.::GO:0071028; P:nuclear mRNA surveillance; IMP:SGD.::GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IMP:SGD.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IC:SGD.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IDA:SGD.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IMP:SGD.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IC:SGD.::GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IMP:SGD.::GO:0034473; P:U1 snRNA 3'-end processing; IMP:SGD.::GO:0034475; P:U4 snRNA 3'-end processing; IMP:SGD.::GO:0034476; P:U5 snRNA 3'-end processing; IMP:SGD.
24	O42872	242	RRP41_SCHPO Exosome complex component ski6 OS...	232	0.00004	47	25	46	GO:0000177; C:cytoplasmic exosome (RNase complex); ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0000176; C:nuclear exosome (RNase complex); ISS:PomBase.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IDA:PomBase.
									GO:0000175; F:3'-5'-exoribonuclease activity; ISS:PomBase.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:PomBase.::GO:0070651; P:nonfunctional rRNA decay; ISS:PomBase.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; ISS:PomBase.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; ISS:PomBase.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; ISS:PomBase.::GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISS:PomBase.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISS:PomBase.
25	Q8U0L9	250	ECX1_PYRFU Probable exosome complex exonuclea...	141	0.00007	46.2	27	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
26	O26779	240	ECX1_METTH Probable exosome complex exonuclea...	206	0.00007	46.2	25	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
27	Q9V119	249	ECX1_PYRAB Probable exosome complex exonuclea...	141	0.0001	45.8	27	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0000175; F:3'-5'-exoribonuclease activity; IEA:HAMAP.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006401; P:RNA catabolic process; IEA:HAMAP.::GO:0006396; P:RNA processing; IEA:InterPro.
28	A1RST0	246	ECX1_PYRIL Probable exosome complex exonuclea...	147	0.0001	45.4	26	41	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
29	A9A5C9	244	ECX1_NITMS Probable exosome complex exonuclea...	155	0.0002	45.1	28	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
30	Q4JB27	243	ECX1_SULAC Probable exosome complex exonuclea...	207	0.0007	43.1	27	47	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.
31	O59223	249	ECX1_PYRHO Probable exosome complex exonuclea...	160	0.001	42.4	24	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
									GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:InterPro.
									GO:0006396; P:RNA processing; IEA:InterPro.

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