Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR080W
Length:
332
Number of sequences:
5887
Description:
YGR080W TWF1 SGDID:S000003312, Chr VII from 642010-643008, Genome Release 64-1-1, Verified ORF, "Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P53250    332   TWF1_YEAST Twinfilin-1 OS=Saccharomyces cerev...3320     676     100     100GO:0030479; C:actin cortical patch; TAS:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.
GO:0003785; F:actin monomer binding; IDA:SGD.
GO:0008154; P:actin polymerization or depolymerization; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0042989; P:sequestering of actin monomers; IDA:SGD.
2Q7ZXP0    349   TWF2A_XENLA Twinfilin-2-A OS=Xenopus laevis (...3019e-19     89     30     47GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
3Q9Z0P5    349   TWF2_MOUSE Twinfilin-2 OS=Mus musculus (Mouse...2961e-18     88.2     28     48GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030175; C:filopodium; IDA:BHF-UCL.::GO:0030027; C:lamellipodium; IDA:BHF-UCL.::GO:0030016; C:myofibril; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0032420; C:stereocilium; IDA:BHF-UCL.
GO:0003785; F:actin monomer binding; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.
GO:0051016; P:barbed-end actin filament capping; IDA:BHF-UCL.::GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0030837; P:negative regulation of actin filament polymerization; IDA:BHF-UCL.::GO:0032532; P:regulation of microvillus length; IC:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; IDA:BHF-UCL.
4Q640W2    349   TWF2B_XENLA Twinfilin-2-B OS=Xenopus laevis (...3003e-18     87.4     30     46GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
5Q5ZM35    349   TWF2_CHICK Twinfilin-2 OS=Gallus gallus (Chic...2971e-17     85.5     28     49GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
6Q6IBS0    349   TWF2_HUMAN Twinfilin-2 OS=Homo sapiens (Human...2961e-17     85.5     28     47GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030175; C:filopodium; ISS:BHF-UCL.::GO:0030426; C:growth cone; IDA:BHF-UCL.::GO:0030027; C:lamellipodium; ISS:BHF-UCL.::GO:0030016; C:myofibril; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.::GO:0032420; C:stereocilium; ISS:BHF-UCL.
GO:0003785; F:actin monomer binding; ISS:BHF-UCL.::GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:BHF-UCL.::GO:0005080; F:protein kinase C binding; IPI:BHF-UCL.
GO:0051016; P:barbed-end actin filament capping; ISS:BHF-UCL.::GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0071363; P:cellular response to growth factor stimulus; IMP:BHF-UCL.::GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.::GO:0045773; P:positive regulation of axon extension; IMP:BHF-UCL.::GO:0010592; P:positive regulation of lamellipodium assembly; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.::GO:0032532; P:regulation of microvillus length; IC:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; ISS:BHF-UCL.
7Q5RFH1    341   TWF2_PONAB Twinfilin-2 OS=Pongo abelii (Sumat...2963e-17     84.7     28     47GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
8Q7QG28    343   TWF_ANOGA Twinfilin OS=Anopheles gambiae (Afr...3522e-16     82     26     44GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
9Q5I082    350   TWF1_XENTR Twinfilin-1 OS=Xenopus tropicalis ...3530.000000000000001     79.7     26     44GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
10Q9VFM9    343   TWF_DROME Twinfilin OS=Drosophila melanogaste...3560.00000000000005     75.5     28     44GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0003779; F:actin binding; IMP:UniProtKB.
GO:0030042; P:actin filament depolymerization; IDA:FlyBase.::GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.::GO:0016319; P:mushroom body development; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.::GO:0030833; P:regulation of actin filament polymerization; IMP:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; IMP:FlyBase.::GO:0048488; P:synaptic vesicle endocytosis; IMP:FlyBase.
11Q68F50    350   TWF1_XENLA Twinfilin-1 OS=Xenopus laevis (Afr...2930.0000000000001     74.7     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
12Q91YR1    350   TWF1_MOUSE Twinfilin-1 OS=Mus musculus (Mouse...3250.0000000000001     74.3     26     45GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:BHF-UCL.::GO:0030175; C:filopodium; IDA:BHF-UCL.::GO:0030016; C:myofibril; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0003785; F:actin monomer binding; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.::GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0051016; P:barbed-end actin filament capping; IDA:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; IDA:BHF-UCL.
13Q6GMH3    347   TWF2_DANRE Twinfilin-2 OS=Danio rerio (Zebraf...2840.0000000000002     73.9     27     45GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
14Q5R7N2    350   TWF1_PONAB Twinfilin-1 OS=Pongo abelii (Sumat...2950.0000000000003     73.2     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
15Q17A58    343   TWF_AEDAE Twinfilin OS=Aedes aegypti (Yellowf...3550.0000000000003     73.2     26     44GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
16Q12792    350   TWF1_HUMAN Twinfilin-1 OS=Homo sapiens (Human...2950.0000000000005     72.8     27     46GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:BHF-UCL.::GO:0030175; C:filopodium; ISS:BHF-UCL.::GO:0030016; C:myofibril; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.
GO:0003785; F:actin monomer binding; ISS:BHF-UCL.::GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:BHF-UCL.
GO:0043538; P:regulation of actin phosphorylation; IDA:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; ISS:BHF-UCL.
17Q5RJR2    350   TWF1_RAT Twinfilin-1 OS=Rattus norvegicus (Ra...3610.000000000001     71.6     25     44
18Q298X4    345   TWF_DROPS Twinfilin OS=Drosophila pseudoobscu...3510.000000000002     70.5     26     43GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
19Q56JV6    350   TWF1_BOVIN Twinfilin-1 OS=Bos taurus (Bovine)...2950.00000000002     67.8     26     45
20Q869T1    335   TWF_DICDI Twinfilin OS=Dictyostelium discoide...2920.00000000002     67.4     27     43GO:0015629; C:actin cytoskeleton; ISS:dictyBase.::GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; ISS:dictyBase.
21O94399    328   TWF1_SCHPO Twinfilin OS=Schizosaccharomyces p...2290.000000005     60.5     25     47GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.
GO:0003785; F:actin monomer binding; ISS:PomBase.
GO:0042989; P:sequestering of actin monomers; ISS:PomBase.
22Q9HF97    143   COFI_ZYGRO Cofilin OS=Zygosaccharomyces rouxi...1120.0003     43.5     29     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
23Q07749    152   ADF2_CAEEL Actin-depolymerizing factor 2, iso...380.0006     43.1     50     63GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
24P86292    122   CADF1_PLAFX Cofilin/actin-depolymerizing fact...880.001     41.6     30     50GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003785; F:actin monomer binding; IMP:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; IMP:UniProtKB.::GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; IMP:UniProtKB.
25Q8I467    122   CADF1_PLAF7 Cofilin/actin-depolymerizing fact...880.001     41.6     30     50GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003785; F:actin monomer binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; ISS:UniProtKB.
26P30175    139   ADF_LILLO Actin-depolymerizing factor OS=Lili...310.001     42     58     77GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
27Q6C0Y0    153   COFI_YARLI Cofilin OS=lipolytica). GN=COF1 Or...1190.002     42     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
28Q9LQ81    140   ADF10_ARATH Actin-depolymerizing factor 10 OS...430.002     41.6     47     65GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
29Q6EUH7    139   ADF1_ORYSJ Actin-depolymerizing factor 1 OS=O...862.8     32.3     33     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
30Q7XSN9    139   ADF6_ORYSJ Actin-depolymerizing factor 6 OS=O...310.003     40.8     55     77GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
31Q570Y6    140   ADF8_ARATH Actin-depolymerizing factor 8 OS=A...1043.8     32     29     42GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
records
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