| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P53046 | 1155 | ROM1_YEAST RHO1 GDP-GTP exchange protein 1 OS... | 1155 | 0 | 2387 | 100 | 100 | GO:0005622; C:intracellular; TAS:SGD. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0004871; F:signal transducer activity; TAS:SGD. | | | | | | | | | | GO:0007015; P:actin filament organization; TAS:SGD.::GO:0007117; P:budding cell bud growth; TAS:SGD.::GO:0030010; P:establishment of cell polarity; TAS:SGD.::GO:0031505; P:fungal-type cell wall organization; TAS:SGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. | 2 | P51862 | 1356 | ROM2_YEAST RHO1 GDP-GTP exchange protein 2 OS... | 972 | 0 | 1043 | 54 | 70 | GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD. | | | | | | | | | | GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:SGD.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:SGD.::GO:0004871; F:signal transducer activity; IGI:SGD. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; IDA:SGD.::GO:0030010; P:establishment of cell polarity; IMP:SGD.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IMP:SGD.::GO:0045807; P:positive regulation of endocytosis; IMP:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IPI:SGD. | 3 | Q9Y7U6 | 1334 | RGF1_SCHPO Rho1 guanine nucleotide exchange f... | 899 | 7e-139 | 460 | 33 | 54 | GO:0000935; C:barrier septum; IDA:PomBase.::GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IGI:PomBase. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0009272; P:fungal-type cell wall biogenesis; IGI:PomBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051518; P:positive regulation of bipolar cell growth; IMP:PomBase.::GO:0035025; P:positive regulation of Rho protein signal transduction; IGI:PomBase.::GO:0008360; P:regulation of cell shape; IGI:PomBase.::GO:0090334; P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process; IGI:PomBase.::GO:0032319; P:regulation of Rho GTPase activity; IGI:PomBase. | 4 | Q9UTR5 | 1158 | RGF2_SCHPO Rho1 guanine nucleotide exchange f... | 988 | 7e-134 | 443 | 30 | 52 | GO:0000935; C:barrier septum; IDA:PomBase.::GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IGI:PomBase. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0030476; P:ascospore wall assembly; IMP:BHF-UCL.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060622; P:regulation of ascospore wall beta-glucan biosynthetic process; IMP:BHF-UCL.::GO:0032319; P:regulation of Rho GTPase activity; IC:PomBase. | 5 | Q9Y7U5 | 1275 | RGF3_SCHPO Rho1 guanine nucleotide exchange f... | 298 | 0.000003 | 55.5 | 23 | 44 | GO:0032153; C:cell division site; IDA:PomBase.::GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IGI:PomBase. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030994; P:primary cell septum disassembly; IMP:PomBase.::GO:0060624; P:regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process; IC:PomBase.::GO:0010590; P:regulation of cytokinetic cell separation; IMP:PomBase.::GO:0032319; P:regulation of Rho GTPase activity; IC:PomBase. | 6 | Q9Z206 | 595 | ARHG8_MOUSE Neuroepithelial cell-transforming... | 307 | 0.0000000000001 | 79.3 | 22 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0032321; P:positive regulation of Rho GTPase activity; ISS:UniProtKB. | 7 | Q7Z628 | 596 | ARHG8_HUMAN Neuroepithelial cell-transforming... | 311 | 0.0000000000003 | 77.8 | 23 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IDA:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0032321; P:positive regulation of Rho GTPase activity; IMP:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 8 | Q9N0A8 | 526 | ARHG3_MACFA Rho guanine nucleotide exchange f... | 318 | 0.00000000001 | 72.4 | 22 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 9 | Q9NR81 | 526 | ARHG3_HUMAN Rho guanine nucleotide exchange f... | 318 | 0.00000000001 | 72.4 | 22 | 47 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc. | 10 | Q5R6F2 | 526 | ARHG3_PONAB Rho guanine nucleotide exchange f... | 318 | 0.00000000001 | 72 | 22 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 11 | Q91X46 | 524 | ARHG3_MOUSE Rho guanine nucleotide exchange f... | 313 | 0.00000000003 | 71.2 | 22 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 12 | Q92888 | 912 | ARHG1_HUMAN Rho guanine nucleotide exchange f... | 281 | 0.00000000007 | 70.5 | 25 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0050771; P:negative regulation of axonogenesis; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 13 | Q61210 | 920 | ARHG1_MOUSE Rho guanine nucleotide exchange f... | 281 | 0.0000000004 | 68.2 | 25 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 14 | Q9Z1I6 | 919 | ARHG1_RAT Rho guanine nucleotide exchange fac... | 281 | 0.0000000008 | 67 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 15 | Q60875 | 985 | ARHG2_MOUSE Rho guanine nucleotide exchange f... | 320 | 0.0000000009 | 67 | 23 | 45 | GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; ISS:UniProtKB.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; ISS:UniProtKB.::GO:0000132; P:establishment of mitotic spindle orientation; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.::GO:0050768; P:negative regulation of neurogenesis; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IDA:MGI. | 16 | Q5ZLX4 | 524 | ARHG3_CHICK Rho guanine nucleotide exchange f... | 314 | 0.000000001 | 65.5 | 20 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 17 | Q9TW28 | 1737 | MYOM_DICDI Myosin-M heavy chain OS=Dictyostel... | 264 | 0.000000002 | 65.9 | 25 | 48 | GO:0042995; C:cell projection; IDA:dictyBase.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016461; C:unconventional myosin complex; ISS:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0016887; F:ATPase activity; ISS:dictyBase.::GO:0000146; F:microfilament motor activity; ISS:dictyBase.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0006972; P:hyperosmotic response; IMP:dictyBase.::GO:0006971; P:hypotonic response; IMP:dictyBase.::GO:0031268; P:pseudopodium organization; IMP:dictyBase.::GO:0035020; P:regulation of Rac protein signal transduction; IDA:dictyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 18 | Q5FVC2 | 985 | ARHG2_RAT Rho guanine nucleotide exchange fac... | 320 | 0.000000004 | 65.1 | 22 | 45 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. | 19 | Q9NZN5 | 1544 | ARHGC_HUMAN Rho guanine nucleotide exchange f... | 276 | 0.000000005 | 64.7 | 24 | 51 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0001664; F:G-protein coupled receptor binding; IDA:MGI.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 20 | O15085 | 1522 | ARHGB_HUMAN Rho guanine nucleotide exchange f... | 281 | 0.000000005 | 64.7 | 23 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0001664; F:G-protein coupled receptor binding; IDA:MGI.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006928; P:cellular component movement; NAS:UniProtKB.::GO:0000910; P:cytokinesis; NAS:UniProtKB.::GO:0030010; P:establishment of cell polarity; NAS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; IDA:UniProtKB.::GO:0006941; P:striated muscle contraction; NAS:UniProtKB.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 21 | Q15811 | 1721 | ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu... | 169 | 0.000000005 | 64.7 | 27 | 49 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc. | 22 | Q8R4H2 | 1543 | ARHGC_MOUSE Rho guanine nucleotide exchange f... | 273 | 0.000000009 | 63.9 | 23 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 23 | Q553D3 | 1173 | GXCJJ_DICDI Rac guanine nucleotide exchange f... | 217 | 0.000000009 | 63.5 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 24 | Q865S3 | 986 | ARHG2_CANFA Rho guanine nucleotide exchange f... | 325 | 0.00000002 | 62.8 | 24 | 44 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. | 25 | Q9ES67 | 1527 | ARHGB_RAT Rho guanine nucleotide exchange fac... | 271 | 0.00000002 | 62.8 | 23 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001505; P:regulation of neurotransmitter levels; TAS:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 26 | B2DCZ9 | 961 | ARHG2_PIG Rho guanine nucleotide exchange fac... | 311 | 0.00000002 | 62.4 | 23 | 45 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 27 | Q9Z0R4 | 1714 | ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo... | 169 | 0.00000002 | 62.8 | 27 | 49 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. | 28 | Q92974 | 986 | ARHG2_HUMAN Rho guanine nucleotide exchange f... | 319 | 0.00000008 | 60.5 | 24 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IDA:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0006886; P:intracellular protein transport; NAS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 29 | Q11100 | 665 | TAG52_CAEEL Putative protein tag-52 OS=Caenor... | 273 | 0.0000006 | 57.4 | 22 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 30 | P97924 | 2959 | KALRN_RAT Kalirin OS=Rattus norvegicus (Rat).... | 198 | 0.00008 | 50.8 | 26 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007409; P:axonogenesis; IDA:RGD.::GO:0035556; P:intracellular signal transduction; IDA:HGNC.::GO:0050773; P:regulation of dendrite development; IDA:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 31 | A2CG49 | 2964 | KALRN_MOUSE Kalirin OS=Mus musculus (Mouse). ... | 198 | 0.00008 | 50.8 | 26 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
