rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | O88842 | 733 | FGD3_MOUSE FYVE, RhoGEF and PH domain-contain... | 265 | 0.0002 | 49.3 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 62 | P91620 | 2061 | SIF2_DROME Protein still life, isoforms C/SIF... | 229 | 0.0002 | 49.7 | 24 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0050803; P:regulation of synapse structure and activity; TAS:FlyBase. | 63 | Q5BKC9 | 701 | NGEF_RAT Ephexin-1 OS=Rattus norvegicus (Rat)... | 198 | 0.0002 | 48.9 | 24 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 64 | Q008S8 | 904 | ECT2L_HUMAN Epithelial cell-transforming sequ... | 178 | 0.0002 | 48.9 | 29 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 65 | O15013 | 1369 | ARHGA_HUMAN Rho guanine nucleotide exchange f... | 274 | 0.0003 | 48.9 | 24 | 46 | GO:0005813; C:centrosome; IDA:BHF-UCL.::GO:0005829; C:cytosol; NAS:BHF-UCL.::GO:0005625; C:soluble fraction; IDA:BHF-UCL. | | | | | | | | | | GO:0019894; F:kinesin binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:BHF-UCL. | | | | | | | | | | GO:0051298; P:centrosome duplication; IMP:BHF-UCL.::GO:0022011; P:myelination in peripheral nervous system; IMP:BHF-UCL.::GO:0033126; P:positive regulation of GTP catabolic process; IDA:BHF-UCL.::GO:0051496; P:positive regulation of stress fiber assembly; IMP:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0090307; P:spindle assembly involved in mitosis; IMP:BHF-UCL. | 66 | Q55E26 | 1198 | GXCB_DICDI Rac guanine nucleotide exchange fa... | 272 | 0.0003 | 48.9 | 24 | 47 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0051764; P:actin crosslink formation; IDA:dictyBase.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0006887; P:exocytosis; IMP:dictyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 67 | Q91ZT5 | 766 | FGD4_MOUSE FYVE, RhoGEF and PH domain-contain... | 155 | 0.0004 | 48.5 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0030035; P:microspike assembly; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 68 | Q9Z0R6 | 1659 | ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo... | 189 | 0.0004 | 48.5 | 23 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 69 | P54100 | 843 | VAV_RAT Proto-oncogene vav OS=Rattus norvegic... | 274 | 0.0004 | 48.1 | 25 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0048468; P:cell development; TAS:RGD.::GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IEP:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 70 | Q8R5L3 | 886 | VPS39_MOUSE Vam6/Vps39-like protein OS=Mus mu... | 154 | 0.0004 | 48.1 | 28 | 45 | GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0016192; P:vesicle-mediated transport; IEA:InterPro. | 71 | Q1ZXH8 | 1632 | GXCDD_DICDI Guanine exchange factor for Rac 3... | 270 | 0.0005 | 48.1 | 22 | 46 | GO:0005938; C:cell cortex; IMP:dictyBase.::GO:0032009; C:early phagosome; IMP:dictyBase.::GO:0005626; C:insoluble fraction; IDA:dictyBase.::GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:dictyBase. | | | | | | | | | | GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IDA:dictyBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IPI:dictyBase. | 72 | Q63406 | 1149 | MCF2L_RAT Guanine nucleotide exchange factor ... | 176 | 0.0005 | 48.1 | 27 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 73 | O94989 | 841 | ARHGF_HUMAN Rho guanine nucleotide exchange f... | 107 | 0.0007 | 47.8 | 26 | 51 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0030425; C:dendrite; ISS:UniProtKB. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:2000297; P:negative regulation of synapse maturation; ISS:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 74 | Q96JC1 | 886 | VPS39_HUMAN Vam6/Vps39-like protein OS=Homo s... | 154 | 0.001 | 47 | 27 | 45 | GO:0030897; C:HOPS complex; IDA:UniProtKB.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 75 | Q08DN7 | 844 | VAV_BOVIN Proto-oncogene vav OS=Bos taurus (B... | 266 | 0.001 | 46.6 | 22 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 76 | O15068 | 1137 | MCF2L_HUMAN Guanine nucleotide exchange facto... | 213 | 0.002 | 46.2 | 25 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 77 | Q96M96 | 766 | FGD4_HUMAN FYVE, RhoGEF and PH domain-contain... | 160 | 0.002 | 45.8 | 24 | 44 | GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 78 | Q8R0J1 | 787 | PKHG6_MOUSE Pleckstrin homology domain-contai... | 270 | 0.003 | 45.4 | 21 | 42 | GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 79 | O88387 | 766 | FGD4_RAT FYVE, RhoGEF and PH domain-containin... | 155 | 0.003 | 45.4 | 23 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0051015; F:actin filament binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; IDA:MGI.::GO:0008360; P:regulation of cell shape; IMP:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 80 | Q06412 | 1307 | TUS1_YEAST Rho1 guanine nucleotide exchange f... | 422 | 0.004 | 45.1 | 21 | 40 | GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:SGD. | | | | | | | | | | GO:0031505; P:fungal-type cell wall organization; IGI:SGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IGI:SGD. | 81 | P15498 | 845 | VAV_HUMAN Proto-oncogene vav OS=Homo sapiens ... | 271 | 0.005 | 44.7 | 21 | 44 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome. | 82 | P98174 | 961 | FGD1_HUMAN FYVE, RhoGEF and PH domain-contain... | 129 | 0.008 | 44.3 | 26 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; IDA:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; IDA:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0009887; P:organ morphogenesis; TAS:ProtInc.::GO:0043088; P:regulation of Cdc42 GTPase activity; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 83 | Q45FX5 | 1007 | VAV_CAEEL Protein vav-1 OS=Caenorhabditis ele... | 287 | 0.011 | 43.5 | 24 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 84 | P52734 | 960 | FGD1_MOUSE FYVE, RhoGEF and PH domain-contain... | 104 | 0.012 | 43.5 | 30 | 46 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0001726; C:ruffle; IDA:MGI. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0008360; P:regulation of cell shape; IDA:UniProtKB. | 85 | Q9NR80 | 690 | ARHG4_HUMAN Rho guanine nucleotide exchange f... | 290 | 0.015 | 43.1 | 20 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IMP:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 86 | Q91VS8 | 1065 | FARP2_MOUSE FERM, RhoGEF and pleckstrin domai... | 274 | 0.018 | 43.1 | 23 | 44 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0019898; C:extrinsic to membrane; IEA:InterPro. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 87 | Q64096 | 1149 | MCF2L_MOUSE Guanine nucleotide exchange facto... | 176 | 0.018 | 43.1 | 26 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005545; F:1-phosphatidylinositol binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI. | | | | | | | | | | GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; IDA:MGI. | 88 | Q60610 | 1591 | TIAM1_MOUSE T-lymphoma invasion and metastasi... | 239 | 0.026 | 42.7 | 22 | 44 | GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0031547; P:brain-derived neurotrophic factor receptor signaling pathway; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB. | 89 | Q13009 | 1591 | TIAM1_HUMAN T-lymphoma invasion and metastasi... | 239 | 0.028 | 42.4 | 22 | 44 | GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 90 | Q5ZJY3 | 917 | GARL3_CHICK GTPase-activating Rap/Ran-GAP dom... | 49 | 0.028 | 42.4 | 35 | 59 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 91 | Q7TT49 | 1713 | MRCKB_RAT Serine/threonine-protein kinase MRC... | 150 | 0.047 | 41.6 | 19 | 45 | GO:0042641; C:actomyosin; IDA:UniProtKB.::GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0017048; F:Rho GTPase binding; IDA:RGD.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. |