Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGR060W
Length:
309
Number of sequences:
5887
Description:
YGR060W ERG25 SGDID:S000003292, Chr VII from 610564-611493, Genome Release 64-1-1, Verified ORF, "C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P53045    309   MSMO_YEAST Methylsterol monooxygenase OS=Sacc...3090     648     100     100GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:SGD.
GO:0000254; F:C-4 methylsterol oxidase activity; IDA:SGD.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006696; P:ergosterol biosynthetic process; IDA:SGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
2O59933    308   MSMO_CANAL Methylsterol monooxygenase OS=Cand...2974e-146     420     65     78GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; ISS:CGD.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; ISS:CGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
3Q9UUH4    300   MSMO_SCHPO Methylsterol monooxygenase OS=Schi...2982e-126     370     57     71GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; ISS:PomBase.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; ISS:PomBase.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
4Q55D52    267   MSMOA_DICDI Putative methylsterol monooxygena...2741e-72     231     43     61GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
5Q55D54    270   MSMOB_DICDI Putative methylsterol monooxygena...2742e-69     223     41     59GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
6Q5R574    293   MSMO1_PONAB Methylsterol monooxygenase 1 OS=P...3002e-56     190     37     54GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
7Q15800    293   MSMO1_HUMAN Methylsterol monooxygenase 1 OS=H...3002e-56     190     37     54GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:ProtInc.
GO:0000254; F:C-4 methylsterol oxidase activity; TAS:ProtInc.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
8Q6UGB2    293   MSMO1_PIG Methylsterol monooxygenase 1 OS=Sus...3022e-56     190     37     55GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
9Q9CRA4    293   MSMO1_MOUSE Methylsterol monooxygenase 1 OS=M...3022e-55     187     37     56GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
10Q5ZLL6    296   MSMO1_CHICK Methylsterol monooxygenase 1 OS=G...2517e-54     184     41     57GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
11O35532    293   MSMO1_RAT Methylsterol monooxygenase 1 OS=Rat...2927e-54     183     38     55GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
12Q8VWZ8    266   SMO22_ARATH Methylsterol monooxygenase 2-2 OS...2782e-53     181     37     56GO:0009941; C:chloroplast envelope; IDA:TAIR.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0080065; F:4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity; IGI:TAIR.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
13Q4R4Q4    293   MSMO1_MACFA Methylsterol monooxygenase 1 OS=M...2834e-53     181     38     54GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
14Q7ZW77    291   MSMO1_DANRE Methylsterol monooxygenase 1 OS=D...2822e-51     177     36     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
15Q9ZW22    272   SMO21_ARATH Methylsterol monooxygenase 2-1 OS...2514e-45     160     37     55GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0080065; F:4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity; IGI:TAIR.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IGI:TAIR.
16Q8L7W5    298   SMO11_ARATH Methylsterol monooxygenase 1-1 OS...2283e-41     150     36     54GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
17Q1EC69    299   SMO12_ARATH Methylsterol monooxygenase 1-2 OS...2282e-40     148     36     54GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0080064; F:4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity; NAS:TAIR.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR.
18F4JLZ6    291   SMO13_ARATH Methylsterol monooxygenase 1-3 OS...2614e-40     147     34     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
19Q4G1G8    270   CH25H_PIG Cholesterol 25-hydroxylase OS=Sus s...2354e-26     108     33     49GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0001567; F:cholesterol 25-hydroxylase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
20Q9Z0F5    298   CH25H_MOUSE Cholesterol 25-hydroxylase OS=Mus...2546e-25     105     32     49GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0001567; F:cholesterol 25-hydroxylase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
21Q4QQV7    298   CH25H_RAT Cholesterol 25-hydroxylase OS=Rattu...2637e-25     105     32     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0001567; F:cholesterol 25-hydroxylase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
22Q1LX59    276   C2512_DANRE Cholesterol 25-hydroxylase-like p...2942e-23     101     27     45GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
23Q5PRC0    251   CH25H_DANRE Cholesterol 25-hydroxylase-like p...2261e-22     98.6     32     49GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
24O95992    272   CH25H_HUMAN Cholesterol 25-hydroxylase OS=Hom...2295e-20     90.9     32     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0001567; F:cholesterol 25-hydroxylase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006699; P:bile acid biosynthetic process; TAS:Reactome.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
25A8WGT1    279   C25L2_DANRE Cholesterol 25-hydroxylase-like p...2982e-17     83.2     26     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
26Q9GKT2    333   CE004_MACFA Uncharacterized protein C5orf4 ho...1690.000000000000002     79     30     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
27O94298    293   YOOF_SCHPO Uncharacterized hydroxylase C887.1...1760.000000000000004     77.4     32     45GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0000170; F:sphingosine hydroxylase activity; ISS:PomBase.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0006675; P:mannosyl-inositol phosphorylceramide metabolic process; IMP:PomBase.
28Q96IV6    333   CE004_HUMAN Uncharacterized protein C5orf4 OS...1360.00000000000001     76.6     33     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
29Q567X1    282   C25L1_DANRE Cholesterol 25-hydroxylase-like p...2520.00000000000002     75.5     27     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
30Q20027    300   C25HL_CAEEL Cholesterol 25-hydroxylase-like p...1740.00000000000003     75.1     27     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
31Q618G2    300   C25HL_CAEBR Cholesterol 25-hydroxylase-like p...2280.000000000001     70.9     26     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
records
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