rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
271 | B5FNE0 | 682 | ATKB_SALDC Potassium-transporting ATPase B ch... | 615 | 9e-20 | 98.6 | 23 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 272 | Q9SH30 | 995 | HMA5_ARATH Putative copper-transporting ATPas... | 277 | 0.004 | 44.7 | 22 | 40 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IEA:InterPro.::GO:0004008; F:copper-exporting ATPase activity; IEA:EC. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0010273; P:detoxification of copper ion; IMP:TAIR. | 273 | B4U8E4 | 684 | ATKB_HYDS0 Potassium-transporting ATPase B ch... | 240 | 0.0003 | 48.1 | 24 | 43 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 274 | A9MUE0 | 682 | ATKB_SALPB Potassium-transporting ATPase B ch... | 615 | 9e-20 | 98.2 | 23 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 275 | B5R670 | 685 | ATKB_SALG2 Potassium-transporting ATPase B ch... | 615 | 1e-19 | 98.2 | 23 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 276 | Q12697 | 1472 | YPK9_YEAST Vacuolar cation-transporting ATPas... | 948 | 1e-19 | 99 | 21 | 38 | GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0015662; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006812; P:cation transport; IEA:InterPro. | 277 | B4TQ22 | 682 | ATKB_SALSV Potassium-transporting ATPase B ch... | 615 | 1e-19 | 98.2 | 23 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 278 | Q8ZQW2 | 682 | ATKB_SALTY Potassium-transporting ATPase B ch... | 615 | 1e-19 | 98.2 | 23 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 279 | Q2YWA3 | 802 | COPA_STAAB Copper-exporting P-type ATPase A O... | 275 | 0.0000003 | 58.2 | 24 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IEA:InterPro.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 280 | Q9LT02 | 1179 | ATY1_ARATH Probable cation-transporting ATPas... | 617 | 2e-19 | 98.2 | 23 | 40 | GO:0005783; C:endoplasmic reticulum; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0015662; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; IEA:InterPro.::GO:0019829; F:cation-transporting ATPase activity; IGI:TAIR.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006875; P:cellular metal ion homeostasis; IMP:TAIR.::GO:0016036; P:cellular response to phosphate starvation; IMP:TAIR.::GO:0010073; P:meristem maintenance; IMP:TAIR.::GO:0009846; P:pollen germination; IMP:TAIR.::GO:0010152; P:pollen maturation; IMP:TAIR.::GO:0048867; P:stem cell fate determination; IMP:TAIR. | 281 | B5EZE3 | 682 | ATKB_SALA4 Potassium-transporting ATPase B ch... | 615 | 2e-19 | 97.4 | 23 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 282 | Q10309 | 1033 | YD56_SCHPO Putative phospholipid-transporting... | 831 | 2e-19 | 98.2 | 24 | 40 | GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0005794; C:Golgi apparatus; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0015662; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004012; F:phospholipid-translocating ATPase activity; IEA:EC. | | | | | | | | | | GO:0070588; P:calcium ion transmembrane transport; TAS:PomBase.::GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; ISS:PomBase. | 283 | Q9CCL1 | 725 | CTPC_MYCLE Probable cation-transporting P-typ... | 278 | 0.014 | 42.7 | 23 | 42 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 284 | P20021 | 727 | CADA1_STAAU Probable cadmium-transporting ATP... | 266 | 0.000000000009 | 72.8 | 22 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008551; F:cadmium-exporting ATPase activity; IEA:EC.::GO:0005261; F:cation channel activity; IEA:InterPro.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW. | 285 | Q6GIX1 | 726 | CADA_STAAR Probable cadmium-transporting ATPa... | 329 | 0.00000000000008 | 79.3 | 23 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008551; F:cadmium-exporting ATPase activity; IEA:EC.::GO:0005261; F:cation channel activity; IEA:InterPro.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 286 | Q64430 | 1491 | ATP7A_MOUSE Copper-transporting ATPase 1 OS=M... | 309 | 0.000004 | 55.1 | 25 | 42 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0043005; C:neuron projection; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0005802; C:trans-Golgi network; IDA:MGI.::GO:0030140; C:trans-Golgi network transport vesicle; ISS:HGNC. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004008; F:copper-exporting ATPase activity; IDA:MGI.::GO:0005515; F:protein binding; IPI:MGI.::GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:MGI. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0001568; P:blood vessel development; IMP:MGI.::GO:0001974; P:blood vessel remodeling; IMP:MGI.::GO:0051216; P:cartilage development; IMP:MGI.::GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.::GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.::GO:0030199; P:collagen fibril organization; IMP:MGI.::GO:0015677; P:copper ion import; IMP:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0010273; P:detoxification of copper ion; IMP:MGI.::GO:0042417; P:dopamine metabolic process; IMP:MGI.::GO:0048251; P:elastic fiber assembly; IMP:MGI.::GO:0051542; P:elastin biosynthetic process; IMP:MGI.::GO:0042414; P:epinephrine metabolic process; IMP:MGI.::GO:0031069; P:hair follicle morphogenesis; IMP:MGI.::GO:0007626; P:locomotory behavior; IMP:MGI.::GO:0048286; P:lung alveolus development; IMP:MGI.::GO:0048553; P:negative regulation of metalloenzyme activity; IMP:MGI.::GO:0043526; P:neuroprotection; IMP:MGI.::GO:0042421; P:norepinephrine biosynthetic process; IMP:MGI.::GO:0018205; P:peptidyl-lysine modification; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0048554; P:positive regulation of metalloenzyme activity; IMP:MGI.::GO:0021860; P:pyramidal neuron development; IMP:MGI.::GO:0010468; P:regulation of gene expression; IMP:MGI.::GO:0002082; P:regulation of oxidative phosphorylation; IMP:MGI.::GO:0001836; P:release of cytochrome c from mitochondria; IMP:MGI.::GO:0019430; P:removal of superoxide radicals; IMP:MGI.::GO:0042428; P:serotonin metabolic process; IMP:MGI.::GO:0043588; P:skin development; IMP:MGI.::GO:0042093; P:T-helper cell differentiation; IMP:MGI.::GO:0006568; P:tryptophan metabolic process; IMP:MGI.::GO:0006570; P:tyrosine metabolic process; IMP:MGI. | 287 | Q47H39 | 688 | ATKB_DECAR Potassium-transporting ATPase B ch... | 631 | 4e-19 | 96.3 | 24 | 41 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 288 | A4SZG8 | 691 | ATKB_POLSQ Potassium-transporting ATPase B ch... | 587 | 5e-19 | 95.9 | 25 | 41 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 289 | Q7N6W6 | 688 | ATKB_PHOLL Potassium-transporting ATPase B ch... | 699 | 7e-19 | 95.5 | 24 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 290 | P70705 | 1492 | ATP7A_RAT Copper-transporting ATPase 1 OS=Rat... | 309 | 0.000003 | 55.1 | 25 | 42 | GO:0016323; C:basolateral plasma membrane; IDA:RGD.::GO:0031526; C:brush border membrane; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0000299; C:integral to membrane of membrane fraction; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0030141; C:secretory granule; IDA:RGD.::GO:0005802; C:trans-Golgi network; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004008; F:copper-exporting ATPase activity; IEA:EC. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0001701; P:in utero embryonic development; IEP:RGD.::GO:0010041; P:response to iron(III) ion; IEP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD. | 291 | P0A502 | 718 | CTPC_MYCTU Probable cation-transporting P-typ... | 215 | 0.27 | 38.9 | 24 | 41 | GO:0005576; C:extracellular region; IGI:MTBBASE.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:MTBBASE. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 292 | P0A503 | 718 | CTPC_MYCBO Probable cation-transporting P-typ... | 215 | 0.27 | 38.9 | 24 | 41 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 293 | P37386 | 804 | CADA2_STAAU Probable cadmium-transporting ATP... | 326 | 0.0000000000003 | 77.8 | 22 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008551; F:cadmium-exporting ATPase activity; IEA:EC.::GO:0005261; F:cation channel activity; IEA:InterPro.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW. | 294 | O31688 | 637 | ZOSA_BACSU Zinc-transporting ATPase OS=Bacill... | 319 | 0.00000000000003 | 80.9 | 27 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005261; F:cation channel activity; IEA:InterPro.::GO:0043682; F:copper-transporting ATPase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016463; F:zinc-exporting ATPase activity; IEA:EC. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 295 | Q8R8I6 | 681 | ATKB_THETN Potassium-transporting ATPase B ch... | 239 | 0.00003 | 51.6 | 26 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 296 | Q64446 | 1462 | ATP7B_MOUSE Copper-transporting ATPase 2 OS=M... | 287 | 0.0000001 | 59.3 | 24 | 44 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005802; C:trans-Golgi network; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:HGNC.::GO:0005507; F:copper ion binding; ISS:HGNC.::GO:0004008; F:copper-exporting ATPase activity; IDA:MGI. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro.::GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.::GO:0006882; P:cellular zinc ion homeostasis; IMP:MGI.::GO:0015680; P:intracellular copper ion transport; IMP:MGI.::GO:0007595; P:lactation; IMP:MGI. | 297 | P0A504 | 797 | CTPE_MYCTU Probable cation-transporting ATPas... | 270 | 0.000000000000007 | 82.8 | 26 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0015662; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006812; P:cation transport; IEA:InterPro. | 298 | P0A505 | 797 | CTPE_MYCBO Probable cation-transporting ATPas... | 270 | 0.000000000000007 | 82.8 | 26 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0015662; F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006812; P:cation transport; IEA:InterPro. | 299 | Q9X5X3 | 827 | ATCU_SINMW Copper-transporting P-type ATPase ... | 280 | 0.00000007 | 60.1 | 21 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005261; F:cation channel activity; IEA:InterPro.::GO:0005507; F:copper ion binding; IEA:InterPro.::GO:0004008; F:copper-exporting ATPase activity; IEA:EC. | | | | | | | | | | GO:0006754; P:ATP biosynthetic process; IEA:InterPro. | 300 | A8GB61 | 689 | ATKB_SERP5 Potassium-transporting ATPase B ch... | 628 | 5e-18 | 92.8 | 24 | 40 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | | 301 | P59219 | 692 | ATKB_LEPIN Potassium-transporting ATPase B ch... | 607 | 5e-18 | 92.8 | 24 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0008556; F:potassium-transporting ATPase activity; IEA:EC. | | | | | | | | | | |