Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGL141W
Length:
910
Number of sequences:
5887
Description:
YGL141W HUL5 SGDID:S000003109, Chr VII from 238353-241085, Genome Release 64-1-1, Verified ORF, "Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31O08759    885   UBE3A_MOUSE Ubiquitin-protein ligase E3A OS=M...3595e-39     160     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
32Q2UBP1    816   RSP5_ASPOR Probable E3 ubiquitin-protein liga...3541e-38     158     32     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
33Q03280    3268   TOM1_YEAST E3 ubiquitin-protein ligase TOM1 O...3602e-38     159     33     50GO:0005730; C:nucleolus; IDA:SGD.
GO:0005488; F:binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.
GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0007067; P:mitosis; IMP:SGD.::GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0006913; P:nucleocytoplasmic transport; IMP:SGD.::GO:0006997; P:nucleus organization; IMP:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0008361; P:regulation of cell size; IMP:SGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
34F8W2M1    904   HACE1_DANRE E3 ubiquitin-protein ligase HACE1...4361e-37     155     29     48GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
35Q756G2    3258   TOM1_ASHGO Probable E3 ubiquitin-protein liga...3643e-37     156     32     48GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005488; F:binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:RefGenome.
GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome.
36E1C656    942   HACE1_CHICK E3 ubiquitin-protein ligase HACE1...4297e-37     153     29     48GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
37Q8IYU2    909   HACE1_HUMAN E3 ubiquitin-protein ligase HACE1...4291e-36     152     29     48GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; IDA:UniProtKB.::GO:0048365; F:Rac GTPase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; IMP:UniProtKB.::GO:0007030; P:Golgi organization; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0016601; P:Rac protein signal transduction; TAS:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
38F1N6G5    909   HACE1_BOVIN E3 ubiquitin-protein ligase HACE1...4292e-36     152     29     48GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
39D3ZBM7    909   HACE1_RAT E3 ubiquitin-protein ligase HACE1 O...4293e-36     151     28     49GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
40Q3U0D9    909   HACE1_MOUSE E3 ubiquitin-protein ligase HACE1...4294e-36     151     28     49GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
41Q8C863    864   ITCH_MOUSE E3 ubiquitin-protein ligase Itchy ...3615e-36     150     31     51GO:0005938; C:cell cortex; IDA:MGI.::GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0050687; P:negative regulation of defense response to virus; IMP:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; IMP:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0002669; P:positive regulation of T cell anergy; IMP:MGI.::GO:0035519; P:protein K29-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI.::GO:0090085; P:regulation of protein deubiquitination; IMP:BHF-UCL.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.
42Q76N89    1606   HECW1_HUMAN E3 ubiquitin-protein ligase HECW1...3737e-36     151     32     50GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
43Q5PQN1    1057   HERC4_RAT Probable E3 ubiquitin-protein ligas...3939e-36     150     31     49GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; ISS:UniProtKB.
44Q6I6G8    1578   HECW2_MOUSE E3 ubiquitin-protein ligase HECW2...3731e-35     150     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
45P39940    809   RSP5_YEAST E3 ubiquitin-protein ligase RSP5 O...3541e-35     149     31     51GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0010008; C:endosome membrane; IDA:SGD.::GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:SGD.::GO:0005794; C:Golgi apparatus; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD.::GO:0000151; C:ubiquitin ligase complex; IDA:MGI.
GO:0035091; F:phosphatidylinositol binding; IDA:SGD.::GO:0043130; F:ubiquitin binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
GO:0034644; P:cellular response to UV; IMP:SGD.::GO:0006333; P:chromatin assembly or disassembly; IMP:SGD.::GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IMP:SGD.::GO:0007005; P:mitochondrion organization; IMP:SGD.::GO:0045723; P:positive regulation of fatty acid biosynthetic process; IMP:SGD.::GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:SGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IPI:SGD.::GO:0006513; P:protein monoubiquitination; IMP:SGD.::GO:0000209; P:protein polyubiquitination; IMP:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0032956; P:regulation of actin cytoskeleton organization; IGI:SGD.::GO:0010794; P:regulation of dolichol biosynthetic process; IMP:SGD.::GO:0032443; P:regulation of ergosterol biosynthetic process; IMP:SGD.::GO:0010793; P:regulation of mRNA export from nucleus; IMP:SGD.::GO:0010796; P:regulation of multivesicular body size; IMP:SGD.::GO:0006808; P:regulation of nitrogen utilization; IGI:SGD.::GO:0019220; P:regulation of phosphate metabolic process; IGI:SGD.::GO:0032880; P:regulation of protein localization; IMP:SGD.::GO:2000203; P:regulation of ribosomal large subunit export from nucleus; IMP:SGD.::GO:2000232; P:regulation of rRNA processing; IMP:SGD.::GO:2000238; P:regulation of tRNA export from nucleus; IMP:SGD.::GO:2000235; P:regulation of tRNA processing; IMP:SGD.::GO:0010795; P:regulation of ubiquinone biosynthetic process; IMP:SGD.::GO:0042493; P:response to drug; IMP:SGD.::GO:0034517; P:ribophagy; IGI:SGD.::GO:0070086; P:ubiquitin-dependent endocytosis; IMP:SGD.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:SGD.
46Q96J02    903   ITCH_HUMAN E3 ubiquitin-protein ligase Itchy ...3611e-35     149     31     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0045236; F:CXCR chemokine receptor binding; IPI:UniProtKB.::GO:0043021; F:ribonucleoprotein complex binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; NAS:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0050687; P:negative regulation of defense response to virus; IMP:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0035519; P:protein K29-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0090085; P:regulation of protein deubiquitination; ISS:BHF-UCL.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB.
47Q9P2P5    1572   HECW2_HUMAN E3 ubiquitin-protein ligase HECW2...3731e-35     150     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
48Q6PAV2    1057   HERC4_MOUSE Probable E3 ubiquitin-protein lig...3932e-35     149     31     49GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; IMP:UniProtKB.
49Q8K4P8    1604   HECW1_MOUSE E3 ubiquitin-protein ligase HECW1...3732e-35     149     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
50Q5GLZ8    1057   HERC4_HUMAN Probable E3 ubiquitin-protein lig...3936e-33     141     31     49GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; ISS:UniProtKB.
51Q9H0M0    922   WWP1_HUMAN NEDD4-like E3 ubiquitin-protein li...3626e-33     141     30     50GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB.
GO:0007417; P:central nervous system development; NAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007165; P:signal transduction; NAS:UniProtKB.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB.
52Q8BZZ3    918   WWP1_MOUSE NEDD4-like E3 ubiquitin-protein li...3626e-33     140     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0030324; P:lung development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0030217; P:T cell differentiation; TAS:UniProtKB.
53Q5RBF2    959   NED4L_PONAB E3 ubiquitin-protein ligase NEDD4...3651e-32     140     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
54Q8CFI0    1004   NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4...3651e-32     140     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
55Q96PU5    975   NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4...3652e-32     139     32     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.
GO:0006883; P:cellular sodium ion homeostasis; NAS:UniProtKB.::GO:0007588; P:excretion; NAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0045807; P:positive regulation of endocytosis; NAS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0042176; P:regulation of protein catabolic process; NAS:UniProtKB.::GO:0010038; P:response to metal ion; IDA:UniProtKB.::GO:0006814; P:sodium ion transport; NAS:UniProtKB.::GO:0030104; P:water homeostasis; NAS:UniProtKB.
56O00308    870   WWP2_HUMAN NEDD4-like E3 ubiquitin-protein li...3587e-32     137     30     49GO:0005737; C:cytoplasm; ISS:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; TAS:ProtInc.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0051224; P:negative regulation of protein transport; IMP:UniProtKB.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB.
57Q9Y0H4    949   SUDX_DROME E3 ubiquitin-protein ligase Su(dx)...3621e-31     137     28     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IMP:UniProtKB.::GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IGI:FlyBase.::GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:UniProtKB.::GO:0019915; P:lipid storage; IDA:FlyBase.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:UniProtKB.::GO:0007219; P:Notch signaling pathway; IGI:FlyBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0035209; P:pupal development; IMP:UniProtKB.::GO:0031623; P:receptor internalization; IMP:UniProtKB.::GO:0032880; P:regulation of protein localization; IMP:FlyBase.::GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:UniProtKB.
58Q9DBH0    870   WWP2_MOUSE NEDD4-like E3 ubiquitin-protein li...3581e-31     136     30     49GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
59Q5RD78    776   HECD2_PONAB Probable E3 ubiquitin-protein lig...3633e-30     132     28     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
GO:0006464; P:protein modification process; IEA:InterPro.
60Q62940    887   NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 O...3775e-30     131     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005902; C:microvillus; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
GO:0006955; P:immune response; IEP:RGD.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB.
61Q8CDU6    774   HECD2_MOUSE Probable E3 ubiquitin-protein lig...3635e-30     131     28     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
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