Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGL062W
Length:
1178
Number of sequences:
5887
Description:
YGL062W PYC1 SGDID:S000003030, Chr VII from 385196-388732, Genome Release 64-1-1, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
391C3NDV7    461   HOSA_SULIY Putative homocitrate synthase OS=S...1510.0006     47.8     23     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
392C3NHU6    461   HOSA_SULIN Putative homocitrate synthase OS=S...1510.0006     47.8     23     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
393C3MYM1    461   HOSA_SULIM Putative homocitrate synthase OS=S...1510.0006     47.8     23     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
394C4KGW9    461   HOSA_SULIK Putative homocitrate synthase OS=S...1510.0006     47.8     23     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
395C3N5A3    461   HOSA_SULIA Putative homocitrate synthase OS=S...1510.0006     47.8     23     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
396Q8THA5    515   LEU1_METAC Probable 2-isopropylmalate synthas...1140.0006     47.8     32     48
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
397Q1LPX2    513   LEU1_RALME 2-isopropylmalate synthase OS=Rals...1270.0006     47.8     24     46
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
398A8H9A1    523   LEU1_SHEPA 2-isopropylmalate synthase OS=Shew...2940.0006     47.4     23     40
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
399B4F1Q4    399   PURT_PROMH Phosphoribosylglycinamide formyltr...3060.0006     47.4     23     40
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0009152; P:purine ribonucleotide biosynthetic process; IEA:InterPro.
400A3CUF2    503   CIMA_METMJ Putative (R)-citramalate synthase ...1520.0006     47.4     28     43
GO:0043714; F:(R)-citramalate synthase activity; IEA:InterPro.::GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.::GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
401C3MPM7    461   HOSA_SULIL Putative homocitrate synthase OS=S...890.0007     47.4     25     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
402Q96Y60    397   PURT_SULTO Phosphoribosylglycinamide formyltr...2270.0007     47     26     39
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0009152; P:purine ribonucleotide biosynthetic process; IEA:InterPro.
403Q9EVE3    437   LEU1_BUCUL 2-isopropylmalate synthase OS=Buch...920.0007     47.4     29     47
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
404B0TQM0    523   LEU1_SHEHH 2-isopropylmalate synthase OS=Shew...2910.0007     47.4     22     40
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
405P58968    516   LEU1_METMA Probable 2-isopropylmalate synthas...1220.0009     47     29     47
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
406Q473V1    513   LEU1_CUPPJ 2-isopropylmalate synthase OS=eutr...1270.001     47     24     46
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
407P35914    325   HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, ...1220.001     46.6     25     46GO:0005759; C:mitochondrial matrix; NAS:UniProtKB.::GO:0005777; C:peroxisome; IDA:UniProtKB.
GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0030145; F:manganese ion binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0046951; P:ketone body biosynthetic process; IDA:UniProtKB.::GO:0006552; P:leucine catabolic process; NAS:UniProtKB.
408Q3AEQ5    509   LEU1_CARHZ 2-isopropylmalate synthase OS=Carb...1930.001     47     24     41
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
409P38060    325   HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, ...1150.001     46.2     27     48GO:0005743; C:mitochondrial inner membrane; IDA:MGI.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.::GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; ISS:UniProtKB.
GO:0009790; P:embryo development; IMP:MGI.::GO:0007005; P:mitochondrion organization; IMP:MGI.
410B8E4K4    522   LEU1_SHEB2 2-isopropylmalate synthase OS=Shew...2840.001     46.6     24     40
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
411Q89A49    390   LEU1_BUCBP Putative 2-isopropylmalate synthas...2680.001     46.2     23     40
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
412Q3M8Q4    391   PURT_ANAVT Phosphoribosylglycinamide formyltr...1830.001     46.2     26     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0009152; P:purine ribonucleotide biosynthetic process; IEA:InterPro.
413B8CM39    523   LEU1_SHEPW 2-isopropylmalate synthase OS=Shew...2910.001     46.6     23     40
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
414A3CZK5    522   LEU1_SHEB5 2-isopropylmalate synthase OS=Shew...2840.001     46.2     24     39
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
415B4F194    519   LEU1_PROMH 2-isopropylmalate synthase OS=Prot...2800.001     46.2     22     39
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
416P97519    325   HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mi...1150.001     45.8     27     48GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
GO:0000062; F:fatty-acyl-CoA binding; IPI:RGD.::GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; ISS:UniProtKB.
GO:0006637; P:acyl-CoA metabolic process; IDA:RGD.::GO:0046951; P:ketone body biosynthetic process; IDA:RGD.::GO:0001889; P:liver development; IEP:RGD.::GO:0070542; P:response to fatty acid; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.::GO:0042594; P:response to starvation; IEP:RGD.
417A6Q4V5    514   LEU1_NITSB 2-isopropylmalate synthase OS=Nitr...2780.002     46.2     24     38
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
418A7I0N8    504   LEU1_CAMHC 2-isopropylmalate synthase OS=CH00...2450.002     46.2     23     37
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
419P65898    429   PURK_MYCTU N5-carboxyaminoimidazole ribonucle...1860.002     45.8     30     45GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO:0034028; F:5-(carboxyamino)imidazole ribonucleotide synthase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:InterPro.::GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:InterPro.
GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
420P65899    429   PURK_MYCBO N5-carboxyaminoimidazole ribonucle...1860.002     45.8     30     45
GO:0034028; F:5-(carboxyamino)imidazole ribonucleotide synthase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:InterPro.::GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:InterPro.
GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
421A6UUH1    391   PURT_META3 Phosphoribosylglycinamide formyltr...2360.002     45.8     26     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0009152; P:purine ribonucleotide biosynthetic process; IEA:InterPro.
records
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