Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGL059W
Length:
491
Number of sequences:
5887
Description:
YGL059W PKP2 SGDID:S000003027, Chr VII from 392223-393698, Genome Release 64-1-1, Verified ORF, "Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P53170    491   PKP2_YEAST Pyruvate dehydrogenase kinase 2, m...4910     1016     100     100GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IMP:SGD.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IMP:SGD.::GO:0018105; P:peptidyl-serine phosphorylation; IMP:SGD.
2Q00972    412   BCKD_RAT [3-methyl-2-oxobutanoate dehydrogena...3807e-27     115     23     43GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; IDA:HGNC.
GO:0047323; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity; IMP:RGD.::GO:0005524; F:ATP binding; IDA:HGNC.::GO:0004674; F:protein serine/threonine kinase activity; IDA:HGNC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0009083; P:branched chain family amino acid catabolic process; IDA:HGNC.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.]
3O55028    412   BCKD_MOUSE [3-methyl-2-oxobutanoate dehydroge...3807e-27     115     23     43GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; ISS:HGNC.
GO:0047323; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0005524; F:ATP binding; ISS:HGNC.::GO:0004674; F:protein serine/threonine kinase activity; ISS:HGNC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0009083; P:branched chain family amino acid catabolic process; ISS:HGNC.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.]
4O14874    412   BCKD_HUMAN [3-methyl-2-oxobutanoate dehydroge...3806e-26     112     22     43GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; ISS:HGNC.
GO:0047323; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0005524; F:ATP binding; ISS:HGNC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; ISS:HGNC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0009083; P:branched chain family amino acid catabolic process; ISS:HGNC.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.]
5Q2KJG8    412   BCKD_BOVIN [3-methyl-2-oxobutanoate dehydroge...3803e-25     110     22     43GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; ISS:HGNC.
GO:0047323; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0005524; F:ATP binding; ISS:HGNC.::GO:0004674; F:protein serine/threonine kinase activity; ISS:HGNC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0009083; P:branched chain family amino acid catabolic process; ISS:HGNC.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.]
6Q16654    411   PDK4_HUMAN [Pyruvate dehydrogenase [lipoamide...520.0003     46.6     38     67GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; TAS:ProtInc.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; TAS:ProtInc.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006090; P:pyruvate metabolic process; TAS:Reactome.::GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome.
7Q1KMR4    412   PDK4_RHIFE [Pyruvate dehydrogenase [lipoamide...520.0005     45.8     38     65GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0042750; P:hibernation; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
8O88345    412   PDK4_SPETR [Pyruvate dehydrogenase [lipoamide...520.0003     46.6     38     67GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0042750; P:hibernation; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
9O54937    412   PDK4_RAT [Pyruvate dehydrogenase [lipoamide]]...520.0001     48.1     40     67GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IDA:RGD.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; TAS:RGD.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
10O70571    412   PDK4_MOUSE [Pyruvate dehydrogenase [lipoamide...520.0001     48.1     40     67GO:0005743; C:mitochondrial inner membrane; IDA:MGI.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; TAS:MGI.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; TAS:MGI.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
11Q15118    436   PDK1_HUMAN [Pyruvate dehydrogenase [lipoamide...460.002     43.9     41     63GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; TAS:ProtInc.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; TAS:ProtInc.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006090; P:pyruvate metabolic process; TAS:Reactome.::GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc.
12P91622    413   PDK_DROME [Pyruvate dehydrogenase [lipoamide]...4310.00000000000003     78.2     21     40GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
13Q64536    407   PDK2_RAT [Pyruvate dehydrogenase [lipoamide]]...380.003     43.9     50     68GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.::GO:0045254; C:pyruvate dehydrogenase complex; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0032403; F:protein complex binding; IDA:RGD.::GO:0046982; F:protein heterodimerization activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IDA:RGD.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
14Q8BFP9    434   PDK1_MOUSE [Pyruvate dehydrogenase [lipoamide...510.002     44.3     39     61GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
15Q9JK42    407   PDK2_MOUSE [Pyruvate dehydrogenase [lipoamide...380.003     43.5     50     68GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
16Q63065    434   PDK1_RAT [Pyruvate dehydrogenase [lipoamide]]...510.002     43.9     39     61GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.::GO:0045254; C:pyruvate dehydrogenase complex; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0032403; F:protein complex binding; IDA:RGD.::GO:0046982; F:protein heterodimerization activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IDA:RGD.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0007166; P:cell surface receptor signaling pathway; IMP:RGD.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
17Q15119    407   PDK2_HUMAN [Pyruvate dehydrogenase [lipoamide...380.003     43.5     50     68GO:0005759; C:mitochondrial matrix; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; TAS:ProtInc.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; TAS:ProtInc.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006090; P:pyruvate metabolic process; TAS:Reactome.::GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome.
18Q15120    406   PDK3_HUMAN [Pyruvate dehydrogenase [lipoamide...510.003     43.9     41     59GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; TAS:ProtInc.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; TAS:ProtInc.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006090; P:pyruvate metabolic process; TAS:Reactome.::GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome.
19Q922H2    415   PDK3_MOUSE [Pyruvate dehydrogenase [lipoamide...510.002     43.9     41     59GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
20P40530    394   PDK_YEAST [Pyruvate dehydrogenase [lipoamide]...350.003     43.5     49     69GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IMP:SGD.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0018105; P:peptidyl-serine phosphorylation; IMP:SGD.
21Q02332    401   PDHK2_CAEEL Probable [pyruvate dehydrogenase ...340.2     37.7     50     68GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
22Q9P6P9    425   PDK_SCHPO [Pyruvate dehydrogenase [lipoamide]...2380.0000001     57.8     24     39GO:0005967; C:mitochondrial pyruvate dehydrogenase complex; ISS:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016887; F:ATPase activity; ISS:PomBase.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; ISS:PomBase.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; ISS:PomBase.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
23O02623    399   PDK_ASCSU [Pyruvate dehydrogenase [lipoamide]...340.022     40.8     50     74GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
24P58662    948   RCSC_SALTY Sensor protein rcsC OS=Salmonella ...431.3     35.4     35     65GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
25Q56128    948   RCSC_SALTI Sensor protein rcsC OS=Salmonella ...431.3     35.4     35     65GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
26A4WPB7    346   PYRC_RHOS5 Dihydroorotase OS=Rhodobacter spha...851.6     34.7     26     52
GO:0004151; F:dihydroorotase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0019856; P:pyrimidine base biosynthetic process; IEA:InterPro.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
27P58402    1197   EVGS_ECO57 Sensor protein evgS OS=Escherichia...341.9     35     44     59GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005215; F:transporter activity; IEA:InterPro.::GO:0000156; F:two-component response regulator activity; IEA:InterPro.::GO:0000155; F:two-component sensor activity; IEA:InterPro.
GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
28P30855    1197   EVGS_ECOLI Sensor protein evgS OS=Escherichia...342.1     34.7     44     59GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0009927; F:histidine phosphotransfer kinase activity; IMP:EcoCyc.::GO:0005215; F:transporter activity; IEA:InterPro.::GO:0000156; F:two-component response regulator activity; IEA:InterPro.::GO:0000155; F:two-component sensor activity; IDA:EcoCyc.
GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.::GO:0046777; P:protein autophosphorylation; IDA:EcoCyc.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
29P19706    1147   MYSB_ACACA Myosin heavy chain IB OS=Acanthamo...666     33.5     39     55GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
30Q9ZQ77    348   MO25L_ARATH MO25-like protein At2g03410 OS=Ar...1396.3     32.7     27     45
GO:0005488; F:binding; IEA:InterPro.
31P59079    673   SYM_OCEIH Methionine--tRNA ligase OS=HTE831)....1436.6     33.1     25     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004825; F:methionine-tRNA ligase activity; IEA:EC.::GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
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