Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YGL023C
Length:
635
Number of sequences:
5887
Description:
YGL023C PIB2 SGDID:S000002991, Chr VII from 452104-450197, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q9HCC9    887   LST2_HUMAN Lateral signaling target protein 2...410.0000006     56.6     51     59GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IMP:UniProtKB.
32Q8IZQ1    3526   WDFY3_HUMAN WD repeat and FYVE domain-contain...370.0000006     56.6     54     70GO:0044444; C:cytoplasmic part; IDA:MGI.::GO:0019898; C:extrinsic to membrane; IDA:MGI.::GO:0005635; C:nuclear envelope; IDA:MGI.
GO:0005545; F:1-phosphatidylinositol binding; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
33Q6VNB8    3508   WDFY3_MOUSE WD repeat and FYVE domain-contain...370.0000007     56.6     54     70
GO:0003831; F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
34O95405    1425   ZFYV9_HUMAN Zinc finger FYVE domain-containin...960.0000007     56.2     35     47GO:0031901; C:early endosome membrane; IDA:UniProtKB.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0008236; F:serine-type peptidase activity; NAS:UniProtKB.
GO:0006897; P:endocytosis; NAS:UniProtKB.::GO:0007183; P:SMAD protein complex assembly; IDA:UniProtKB.::GO:0007184; P:SMAD protein import into nucleus; IMP:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
35O96838    1809   FYV1_DROME Putative 1-phosphatidylinositol 3-...980.0000007     56.2     33     51GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; ISS:UniProtKB.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IMP:FlyBase.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0008333; P:endosome to lysosome transport; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; ISS:UniProtKB.
36B0WAQ0    907   LST2_CULQU Lateral signaling target protein 2...430.0000009     55.8     44     53
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
37B0G126    2656   FYV1_DICDI 1-phosphatidylinositol 3-phosphate...450.000001     56.2     47     58GO:0005739; C:mitochondrion; ISS:dictyBase.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; ISS:dictyBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
38Q17AN2    912   LST2_AEDAE Lateral signaling target protein 2...430.000001     55.5     44     53
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
39Q9Z1T6    2097   FYV1_MOUSE 1-phosphatidylinositol 3-phosphate...370.000001     55.8     51     68GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
40Q9Y2I7    2098   FYV1_HUMAN 1-phosphatidylinositol 3-phosphate...370.000001     55.5     51     68GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; TAS:HGNC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.::GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
41A8XJZ8    651   LST2_CAEBR Lateral signaling target protein 2...970.000002     54.7     30     41
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
42Q6ZV73    1430   FGD6_HUMAN FYVE, RhoGEF and PH domain-contain...350.000002     54.7     54     63GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
43Q7Z3T8    1539   ZFY16_HUMAN Zinc finger FYVE domain-containin...340.000003     54.7     50     68GO:0031901; C:early endosome membrane; TAS:Reactome.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008565; F:protein transporter activity; IMP:UniProtKB.
GO:0030509; P:BMP signaling pathway; TAS:Reactome.::GO:0016197; P:endosome transport; IMP:UniProtKB.::GO:0006622; P:protein targeting to lysosome; IMP:UniProtKB.::GO:0030100; P:regulation of endocytosis; TAS:UniProtKB.::GO:0016050; P:vesicle organization; NAS:UniProtKB.
44Q80U44    1528   ZFY16_MOUSE Zinc finger FYVE domain-containin...1110.000003     54.3     30     48GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
45Q7QAJ2    1161   LST2_ANOGA Lateral signaling target protein 2...430.000003     53.9     44     53
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
46A8QCE4    619   LST2_BRUMA Lateral signaling target protein 2...340.000005     53.1     56     65
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
47Q54CH1    580   ADCA_DICDI Arrestin domain-containing protein...340.000006     53.1     56     68GO:0005813; C:centrosome; IDA:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
48Q9TZD0    661   LST2_CAEEL Lateral signaling target protein 2...340.000006     53.1     50     59
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase.
GO:0040027; P:negative regulation of vulval development; IMP:WormBase.
49Q15075    1411   EEA1_HUMAN Early endosome antigen 1 OS=Homo s...340.000006     53.1     47     68GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; IDA:UniProtKB.::GO:0005624; C:membrane fraction; TAS:ProtInc.
GO:0005545; F:1-phosphatidylinositol binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; NAS:UniProtKB.::GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:UniProtKB.
GO:0045022; P:early endosome to late endosome transport; NAS:UniProtKB.::GO:0016189; P:synaptic vesicle to endosome fusion; TAS:UniProtKB.::GO:0006906; P:vesicle fusion; IMP:UniProtKB.
50P34756    2278   FAB1_YEAST 1-phosphatidylinositol 3-phosphate...380.000009     52.8     47     61GO:0010008; C:endosome membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0070772; C:PAS complex; IDA:SGD.
GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.
GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
51Q8BL66    1411   EEA1_MOUSE Early endosome antigen 1 OS=Mus mu...340.00001     52.8     47     68GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.::GO:0005969; C:serine-pyruvate aminotransferase complex; IDA:MGI.
GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006897; P:endocytosis; ISS:UniProtKB.
52Q5UR69    701   YL615_MIMIV Putative phosphatidylinositol kin...340.00002     51.2     50     68
GO:0016301; F:kinase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
53Q96M96    766   FGD4_HUMAN FYVE, RhoGEF and PH domain-contain...750.00002     51.2     36     47GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
54Q9BQS8    1478   FYCO1_HUMAN FYVE and coiled-coil domain-conta...380.00003     51.2     42     63GO:0005776; C:autophagic vacuole; IDA:UniProtKB.::GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.::GO:0016021; C:integral to membrane; IEA:InterPro.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0005764; C:lysosome; IDA:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0072383; P:plus-end-directed vesicle transport along microtubule; IMP:UniProtKB.
55Q4P7Q1    916   VPS27_USTMA Vacuolar protein sorting-associat...800.00003     50.8     30     41GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
56Q7ZUV1    247   PKHF2_DANRE Pleckstrin homology domain-contai...770.0001     47.8     35     49
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
57O13821    610   VPS27_SCHPO Vacuolar protein sorting-associat...250.0002     48.5     60     68GO:0005829; C:cytosol; IDA:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0033565; C:ESCRT-0 complex; IPI:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005628; C:prospore membrane; IDA:PomBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; ISS:PomBase.::GO:0043130; F:ubiquitin binding; IMP:PomBase.
GO:0031321; P:ascospore-type prospore assembly; IGI:PomBase.::GO:0006897; P:endocytosis; IMP:PomBase.::GO:0006900; P:membrane budding; IC:PomBase.::GO:0045053; P:protein retention in Golgi apparatus; ISS:PomBase.::GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:PomBase.
58Q5PQT2    1194   MTMR3_RAT Myotubularin-related protein 3 OS=R...340.0002     48.5     50     62GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
59Q13615    1198   MTMR3_HUMAN Myotubularin-related protein 3 OS...340.0002     48.5     50     62GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.
GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
60O88387    766   FGD4_RAT FYVE, RhoGEF and PH domain-containin...1480.0002     48.1     25     42GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
GO:0051015; F:actin filament binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; IDA:MGI.::GO:0008360; P:regulation of cell shape; IMP:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
61Q8K296    1196   MTMR3_MOUSE Myotubularin-related protein 3 OS...340.0002     48.1     50     62
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.
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